{"id":"https://openalex.org/W2009852657","doi":"https://doi.org/10.1128/aac.05182-14","title":"Reply to \u201cAdequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future\u201d","display_name":"Reply to \u201cAdequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future\u201d","publication_year":2015,"publication_date":"2015-03-11","ids":{"openalex":"https://openalex.org/W2009852657","doi":"https://doi.org/10.1128/aac.05182-14","mag":"2009852657","pmid":"https://pubmed.ncbi.nlm.nih.gov/25762793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4356803"},"language":"en","primary_location":{"id":"doi:10.1128/aac.05182-14","doi":"https://doi.org/10.1128/aac.05182-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.05182-14","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4356803","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077354505","display_name":"Ana Requena\u2010M\u00e9ndez","orcid":"https://orcid.org/0000-0002-4422-241X","observed_orcids":["https://orcid.org/0000-0002-4422-241X"]},"institutions":[{"id":"https://openalex.org/I197097402","display_name":"Universidad Peruana Cayetano Heredia","ror":"https://ror.org/03yczjf25","country_code":"PE","type":"education","lineage":["https://openalex.org/I197097402"]},{"id":"https://openalex.org/I4210148332","display_name":"Barcelona Institute for Global Health","ror":"https://ror.org/03hjgt059","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210148332","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES","PE"],"is_corresponding":false,"raw_author_name":"Ana Requena-M\u00e9ndez","raw_affiliation_strings":["ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Spain","Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210148332","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru","institution_ids":["https://openalex.org/I197097402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085271816","display_name":"Geraint Davies","orcid":"https://orcid.org/0000-0002-3819-490X","observed_orcids":["https://orcid.org/0000-0002-3819-490X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geraint Davies","raw_affiliation_strings":["Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060911998","display_name":"David Moore","orcid":"https://orcid.org/0000-0002-3748-0154","observed_orcids":["https://orcid.org/0000-0002-3748-0154","https://orcid.org/0000-0002-5151-9748"]},"institutions":[{"id":"https://openalex.org/I197097402","display_name":"Universidad Peruana Cayetano Heredia","ror":"https://ror.org/03yczjf25","country_code":"PE","type":"education","lineage":["https://openalex.org/I197097402"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB","PE"],"is_corresponding":false,"raw_author_name":"David A. J. Moore","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru","TB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom","dTB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru","institution_ids":["https://openalex.org/I197097402"]},{"raw_affiliation_string":"TB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"dTB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"4","first_page":"2475","last_page":"2475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.14010000228881836,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/drug-exposure","display_name":"drug exposure","score":0.3160000145435333},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.6890000104904175},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6872509121894836},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6764669418334961},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5789411067962646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5328996777534485},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.518217146396637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4620937407016754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07041552662849426}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007538","descriptor_name":"Isoniazid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.05182-14","doi":"https://doi.org/10.1128/aac.05182-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.05182-14","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4356803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4356803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:25762793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25762793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Letter"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4356803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4356803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W291666108","https://openalex.org/W1593274271","https://openalex.org/W2078032948","https://openalex.org/W2130597520","https://openalex.org/W2141228465","https://openalex.org/W2167976809"],"related_works":["https://openalex.org/W2078032948","https://openalex.org/W7058291822","https://openalex.org/W4238100222","https://openalex.org/W3198651392","https://openalex.org/W1540102007","https://openalex.org/W2610175840","https://openalex.org/W2129326875","https://openalex.org/W2735459542","https://openalex.org/W7002238009","https://openalex.org/W7058550824"],"abstract_inverted_index":{"We":[0],"thank":[1],"Sturkenboom":[2],"et":[3],"al.":[4],"([1][1])":[5],"for":[6],"their":[7],"interest":[8],"in":[9,36,47],"our":[10],"study":[11,17],"and":[12,25],"[their":[13],"comments][2].":[14],"The":[15],"pragmatic":[16],"design":[18],"based":[19],"on":[20],"two":[21],"sampling":[22,39],"points,":[23],"2":[24],"6":[26],"h":[27],"after":[28],"drug":[29],"intake,":[30],"reflected":[31],"the":[32],"real-world":[33],"approach":[34],"taken":[35],"this":[37],"study,":[38],"patients":[40],"attending":[41],"a":[42],"government":[43],"clinic":[44],"rather":[45],"than":[46]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}