{"id":"https://openalex.org/W2009847979","doi":"https://doi.org/10.1089/hum.1998.9.8-1223","title":"Similarity of Strain- and Route-Dependent Murine Responses to an Adenovirus Vector Using the Homologous Thrombopoietin cDNA as the Reporter Genes","display_name":"Similarity of Strain- and Route-Dependent Murine Responses to an Adenovirus Vector Using the Homologous Thrombopoietin cDNA as the Reporter Genes","publication_year":1998,"publication_date":"1998-05-20","ids":{"openalex":"https://openalex.org/W2009847979","doi":"https://doi.org/10.1089/hum.1998.9.8-1223","mag":"2009847979","pmid":"https://pubmed.ncbi.nlm.nih.gov/9625262"},"language":"en","primary_location":{"id":"doi:10.1089/hum.1998.9.8-1223","doi":"https://doi.org/10.1089/hum.1998.9.8-1223","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.8-1223","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064462352","display_name":"Motoyoshi Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Motoyoshi Suzuki","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, NY 10021, USA","institution_ids":["https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028707363","display_name":"Ravi N. Singh","orcid":"https://orcid.org/0000-0003-0750-1804","observed_orcids":["https://orcid.org/0000-0003-0750-1804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malcolm A. S. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055615075","display_name":"Wenru Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Ru Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald G. Crystal","raw_affiliation_strings":["Address reprint requests to: Dr. Ronald G. Crystal, Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, 520 East 70th Street, ST505, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to: Dr. Ronald G. Crystal, Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, 520 East 70th Street, ST505, New York, NY 10021","institution_ids":["https://openalex.org/I4405272987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064433832"],"corresponding_institution_ids":["https://openalex.org/I4405272987"],"apc_list":null,"apc_paid":null,"fwci":2.7004,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.89994317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"8","first_page":"1223","last_page":"1231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7559999823570251},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/reporter-genes","display_name":"reporter genes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.5389999747276306},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.593999981880188},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocyte-response","display_name":"cytotoxic T lymphocyte response","score":0.8429999947547913},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7210000157356262},{"id":"https://openalex.org/keywords/beta2-microglobulin-deficiency","display_name":"beta2-microglobulin deficiency","score":0.8640000224113464},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.5759999752044678},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8199999928474426},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":1.0},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.7156394720077515},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.6803292036056519},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6781646013259888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6641975045204163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6371273994445801},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.6040289998054504},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5671154856681824},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.49194929003715515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4792375862598419},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4439144432544708},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4338865876197815},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41141775250434875},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39044860005378723},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.23740997910499573},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.189459890127182},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08878955245018005},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08666852116584778},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.1998.9.8-1223","doi":"https://doi.org/10.1089/hum.1998.9.8-1223","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.8-1223","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:9625262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9625262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5149968930","display_name":null,"funder_award_id":"P01 HL 51746-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7154940772","display_name":"Gene Therapy for Cystic Fibrosis","funder_award_id":"P01HL051746","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W18142307","https://openalex.org/W114318986","https://openalex.org/W120480743","https://openalex.org/W268307997","https://openalex.org/W1927178045","https://openalex.org/W1929630117","https://openalex.org/W1964914116","https://openalex.org/W1965172479","https://openalex.org/W1965372133","https://openalex.org/W1965375035","https://openalex.org/W1980401440","https://openalex.org/W1990797461","https://openalex.org/W1996439387","https://openalex.org/W1998100163","https://openalex.org/W1998290936","https://openalex.org/W2005059927","https://openalex.org/W2015111081","https://openalex.org/W2015219383","https://openalex.org/W2016200465","https://openalex.org/W2017614842","https://openalex.org/W2019318413","https://openalex.org/W2019890805","https://openalex.org/W2027640038","https://openalex.org/W2029426142","https://openalex.org/W2051595184","https://openalex.org/W2062144971","https://openalex.org/W2062363361","https://openalex.org/W2067157368","https://openalex.org/W2077117005","https://openalex.org/W2078321284","https://openalex.org/W2079209506","https://openalex.org/W2082032640","https://openalex.org/W2082275088","https://openalex.org/W2088045093","https://openalex.org/W2088359823","https://openalex.org/W2089708292","https://openalex.org/W2090781939","https://openalex.org/W2090864647","https://openalex.org/W2094646089","https://openalex.org/W2114126275","https://openalex.org/W2129859001","https://openalex.org/W2131095976","https://openalex.org/W2151902657","https://openalex.org/W2156119419","https://openalex.org/W2166835758","https://openalex.org/W2419332336","https://openalex.org/W2419618029"],"related_works":["https://openalex.org/W268307997","https://openalex.org/W2019890805","https://openalex.org/W2071442285","https://openalex.org/W2036660086","https://openalex.org/W2154953872","https://openalex.org/W2332645155","https://openalex.org/W1963828353","https://openalex.org/W1927178045","https://openalex.org/W2003665511","https://openalex.org/W2067453386"],"abstract_inverted_index":{"Replication-deficient":[0],"adenovirus":[1,381],"(Ad)":[2],"vectors":[3],"are":[4],"effective":[5],"in":[6,9,19,83,139,167,179,227,244,270,304,308,339,350,417],"transferring":[7],"genes":[8],"vivo,":[10],"but":[11],"their":[12],"use":[13,109],"is":[14,405],"associated":[15],"with":[16,136,164,273,283],"significant":[17],"variation":[18,52],"the":[20,39,44,47,84,88,108,117,124,130,144,160,165,172,180,200,220,236,248,251,262,266,284,287,293,305,309,317,322,334,340,369,402],"extent":[21],"and/or":[22],"duration":[23],"of":[24,30,36,38,46,72,110,141,176,219,231,239,250,265,297,324,336,371,379,410,415,424],"expression":[25,373,411],"observed":[26],"among":[27],"different":[28,34],"strains":[29,150,291],"experimental":[31,318],"animals":[32,342],"and":[33,50,90,100,146,204,277,289,300,331,352,422],"routes":[35],"administration":[37,94,99,103,128,218,264,378],"vector.":[40,162,358,382],"We":[41,359],"have":[42,360],"minimized":[43],"variables":[45],"heterologous":[48,329],"transgene":[49,366,372,387,420],"animal-to-animal":[51],"by":[53,97,104,212,258,320,332,391],"constructing":[54],"an":[55,184,356,380],"Ad":[56,118,252,298,357],"vector":[57,168,222,253,268,403],"encoding":[58],"murine":[59,364],"thrombopoietin":[60],"(mTPO,":[61],"AdmTPO),":[62],"a":[63,68,111,115,152,228,274,328,362,413],"homologous":[64,112,363],"protein":[65],"that":[66,76,315,386,408],"induces":[67],"physiologic":[69],"response":[70,157,326],"(elevation":[71],"blood":[73],"platelet":[74,240,271,392],"levels)":[75],"can":[77,346],"be":[78,255,347],"followed":[79],"sequentially":[80],"over":[81,129,170,280,343,394],"time":[82,281],"same":[85,294,341],"animal.":[86],"Using":[87],"C57BL/6":[89,145,288],"BALB/c":[91,147,290],"stains,":[92],"liver":[93,125,181],"was":[95,120],"accomplished":[96],"intravenous":[98,127,285,375],"skeletal":[101],"muscle":[102,306],"direct":[105],"injection.":[106],"Despite":[107],"cDNA":[113],"as":[114,307,389],"transgene,":[116,330],"genome":[119,169,299,404],"rapidly":[121],"lost":[122],"from":[123],"after":[126],"first":[131,201],"1":[132,397],"to":[133,183,195,209,214,223,242,327,355,367,398,419],"2":[134,188,202,399],"weeks,":[135,203],"no":[137],"difference":[138],"pattern":[140],"decline":[142,166],"between":[143],"strains.":[148],"Both":[149],"exhibited":[151],"cytotoxic":[153],"T":[154],"lymphocyte":[155],"(CTL)":[156],"directed":[158],"against":[159],"AdmTPO":[161,221,267],"Consistent":[163],"time,":[171,344,395],"initial":[173],"high":[174],"levels":[175,241,272,303],"mTPO":[177,301],"mRNA":[178,302],"declined":[182],"undetectable":[185],"level":[186,211],"within":[187,199],"weeks.":[189],"Platelet":[190],"counts":[191],"peaked":[192],"at":[193],"8-":[194],"10-fold":[196],"above":[197],"baseline":[198],"then":[205],"gradually":[206],"declined,":[207],"returning":[208],"normal":[210,243],"50":[213],"60":[215],"days.":[216],"Intravenous":[217],"\u03b22-microglobulin-deficient":[224],"mice":[225,246],"resulted":[226,269],"longer":[229],"persistence":[230,370,409],"elevated":[232],"platelets":[233],"levels,":[234],"although":[235],"eventual":[237],"return":[238],"these":[245,312],"suggests":[247],"elimination":[249],"cannot":[254],"explained":[256],"solely":[257],"CTL":[259],"response.":[260],"Although":[261],"intramuscular":[263,377],"lower":[275],"peak":[276],"minor":[278],"differences":[279],"compared":[282],"route,":[286],"demonstrated":[292],"rapid":[295],"loss":[296],"liver.":[310],"Together,":[311],"observations":[313],"suggest":[314],"simplifying":[316],"design":[319],"eliminating":[321],"variable":[323],"host":[325],"following":[333,374],"consequences":[335],"gene":[337],"transfer":[338],"there":[345],"remarkable":[348],"similarity":[349],"strain-":[351],"route-dependent":[353],"responses":[354],"used":[361],"thrombopoetin":[365],"evaluate":[368],"or":[376],"The":[383],"results":[384],"demonstrate":[385],"expression,":[388],"measured":[390],"number":[393,414],"lasts":[396],"months":[400],"before":[401],"eliminated,":[406],"suggesting":[407],"involves":[412],"parameters":[416],"addition":[418],"immunogenicity":[421],"route":[423],"administration.":[425]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}