{"id":"https://openalex.org/W2009808992","doi":"https://doi.org/10.3109/02656736.2011.631963","title":"Hyperthermia worsens ischaemic brain injury through destruction of microvessels in an embolic model in rats","display_name":"Hyperthermia worsens ischaemic brain injury through destruction of microvessels in an embolic model in rats","publication_year":2012,"publication_date":"2012-01-11","ids":{"openalex":"https://openalex.org/W2009808992","doi":"https://doi.org/10.3109/02656736.2011.631963","mag":"2009808992","pmid":"https://pubmed.ncbi.nlm.nih.gov/22235782"},"language":"en","primary_location":{"id":"doi:10.3109/02656736.2011.631963","doi":"https://doi.org/10.3109/02656736.2011.631963","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02656736.2011.631963","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02656736.2011.631963?needAccess=true&role=button","source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/02656736.2011.631963?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077791798","display_name":"Qiang Meng","orcid":"https://orcid.org/0000-0002-7888-5545","observed_orcids":["https://orcid.org/0000-0002-7888-5545"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4210091044","display_name":"First People's Hospital of Yunnan Province","ror":"https://ror.org/00c099g34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091044"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Qiang Meng","raw_affiliation_strings":["Department of Neurology, the First People's Hospital of Yunnan Province, Kunming, PR China","Department of Neurology, the First People's Hospital of Yunnan Province, Kunming, PR China; Stroke Research Laboratory, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First People's Hospital of Yunnan Province, Kunming, PR China","institution_ids":["https://openalex.org/I4210091044"]},{"raw_affiliation_string":"Department of Neurology, the First People's Hospital of Yunnan Province, Kunming, PR China; Stroke Research Laboratory, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4210091044"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chunyan He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126417","display_name":"Central Illinois Neuroscience Foundation","ror":"https://ror.org/031kmgt53","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126417"]},{"id":"https://openalex.org/I47301684","display_name":"Illinois State University","ror":"https://ror.org/050kcr883","country_code":"US","type":"education","lineage":["https://openalex.org/I47301684"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunyan He","raw_affiliation_strings":["School of Biological Science, Illinois State University, Normal, USA; Central Illinois Neuroscience Foundation, Bloomington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science, Illinois State University, Normal, USA; Central Illinois Neuroscience Foundation, Bloomington, USA","institution_ids":["https://openalex.org/I4210126417","https://openalex.org/I47301684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050507154","display_name":"Ashfaq M Shuaib","orcid":"https://orcid.org/0000-0002-3380-7068","observed_orcids":["https://orcid.org/0000-0002-3380-7068"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ashfaq Shuaib","raw_affiliation_strings":["Stroke Research Laboratory, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Research Laboratory, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025618294","display_name":"Chen Xu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4210126417","display_name":"Central Illinois Neuroscience Foundation","ror":"https://ror.org/031kmgt53","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126417"]},{"id":"https://openalex.org/I47301684","display_name":"Illinois State University","ror":"https://ror.org/050kcr883","country_code":"US","type":"education","lineage":["https://openalex.org/I47301684"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Chen Xu Wang","raw_affiliation_strings":["Stroke Research Laboratory, University of Alberta, Edmonton, Canada; School of Biological Science, Illinois State University, Normal, USA; Central Illinois Neuroscience Foundation, Bloomington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Research Laboratory, University of Alberta, Edmonton, Canada; School of Biological Science, Illinois State University, Normal, USA; Central Illinois Neuroscience Foundation, Bloomington, USA","institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4210126417","https://openalex.org/I47301684"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025618294"],"corresponding_institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4210126417","https://openalex.org/I47301684"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":0.8014,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77579092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"1","first_page":"24","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.3433000147342682,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/microvascular-integrity","display_name":"microvascular integrity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.9160000085830688},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.843999981880188},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7645268440246582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.690535843372345},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.5951387286186218},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.5280675888061523},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5080063939094543},{"id":"https://openalex.org/C2779333224","wikidata":"https://www.wikidata.org/wiki/Q809756","display_name":"Basal lamina","level":3,"score":0.5029475092887878},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.476189523935318},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4736707806587219},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.46892720460891724},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.364102303981781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2800159156322479},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010960","descriptor_name":"Plasminogen Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020520","descriptor_name":"Brain Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020520","descriptor_name":"Brain Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024141","descriptor_name":"Collagen Type IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/02656736.2011.631963","doi":"https://doi.org/10.3109/02656736.2011.631963","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02656736.2011.631963","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02656736.2011.631963?needAccess=true&role=button","source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},{"id":"pmid:22235782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22235782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/02656736.2011.631963","doi":"https://doi.org/10.3109/02656736.2011.631963","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02656736.2011.631963","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02656736.2011.631963?needAccess=true&role=button","source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4923298254","display_name":"MMPs contribute to hyperthermia-enhanced vascular injury","funder_award_id":"R15NS072858","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009808992.pdf","grobid_xml":"https://content.openalex.org/works/W2009808992.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W189342708","https://openalex.org/W1495724646","https://openalex.org/W1752372658","https://openalex.org/W1754114568","https://openalex.org/W1764824114","https://openalex.org/W1970881264","https://openalex.org/W1986595185","https://openalex.org/W1989171577","https://openalex.org/W1990711278","https://openalex.org/W1992981081","https://openalex.org/W1993720383","https://openalex.org/W1994591232","https://openalex.org/W2005675003","https://openalex.org/W2011125535","https://openalex.org/W2017608595","https://openalex.org/W2020500819","https://openalex.org/W2026989777","https://openalex.org/W2031163563","https://openalex.org/W2032362734","https://openalex.org/W2035569448","https://openalex.org/W2036489895","https://openalex.org/W2046247898","https://openalex.org/W2049846962","https://openalex.org/W2049887416","https://openalex.org/W2050054991","https://openalex.org/W2053525375","https://openalex.org/W2054038482","https://openalex.org/W2058902596","https://openalex.org/W2059551548","https://openalex.org/W2068628534","https://openalex.org/W2070543132","https://openalex.org/W2074786710","https://openalex.org/W2075606347","https://openalex.org/W2089679794","https://openalex.org/W2113892795","https://openalex.org/W2125683177","https://openalex.org/W2126394436","https://openalex.org/W2126634468","https://openalex.org/W2138684097","https://openalex.org/W2149116325","https://openalex.org/W2155215582","https://openalex.org/W2170809171"],"related_works":["https://openalex.org/W2359008640","https://openalex.org/W2088331272","https://openalex.org/W1976807374","https://openalex.org/W2065603524","https://openalex.org/W2036503151","https://openalex.org/W7035360206","https://openalex.org/W2404921381","https://openalex.org/W1993203875","https://openalex.org/W2894990141","https://openalex.org/W2068628534"],"abstract_inverted_index":{"PURPOSE:":[0],"Basal":[1],"lamina":[2,150],"is":[3,26],"a":[4,13,52],"major":[5],"part":[6],"of":[7,19,23,34,95,147,223,231],"the":[8,17,32,38,56,79,134,139,145,171,188,221,229,237],"microvascular":[9,35,148,224],"wall":[10],"and":[11,70,86,99,101,105,126,156,162,176,204,234],"plays":[12],"critical":[14],"role":[15],"in":[16,37,236],"integrity":[18,36,225],"microvasculature.":[20],"The":[21,93],"aim":[22],"this":[24],"study":[25],"to":[27,138,211],"determine":[28],"whether":[29],"hyperthermia":[30,114,142,219],"worsens":[31],"destruction":[33,222],"ischaemic":[39,238],"injured":[40],"brain.":[41],"MATERIALS":[42],"AND":[43],"METHODS:":[44],"Focal":[45],"cerebral":[46,58,239],"ischaemia":[47],"was":[48],"induced":[49],"by":[50,109,227],"embolising":[51],"pre-formed":[53],"clot":[54],"into":[55],"middle":[57],"artery":[59],"(MCA).":[60],"Rats":[61],"received":[62],"either":[63],"normothermic":[64,140],"or":[65],"hyperthermic":[66],"treatment.":[67],"Neurological":[68],"score":[69,128],"infarct":[71,117],"size":[72],"were":[73,88,107],"evaluated":[74],"at":[75,130,158,174,191,202],"24":[76,131,163,177,205],"h":[77,132,160,164,178,193,206],"after":[78,133,166,179,207],"MCA":[80,135,167,180,208],"occlusion.":[81,136,168],"Microvascular":[82],"collagen":[83,153],"type":[84,154],"IV":[85,155],"laminin":[87],"measured":[89],"with":[90,113,183],"fluorescence":[91],"microscopy.":[92],"activities":[94,230],"matrix":[96],"metalloproteinases":[97],"(MMP-2":[98],"MMP-9)":[100],"plasminogen":[102],"activators":[103],"(tPA":[104],"uPA)":[106],"determined":[108],"zymography.":[110],"RESULTS:":[111],"Treatment":[112],"significantly":[115,143,201],"increased":[116,170,187],"volume":[118],"(p<0.01),":[119,122],"cortex":[120],"swelling":[121,124],"striatum":[123],"(p<0.05)":[125],"neurologic":[127],"(p<0.01)":[129,165],"Compared":[137],"groups,":[141],"worsened":[144],"losses":[146],"basal":[149],"structure":[151],"proteins,":[152],"laminin,":[157],"6":[159,175,192,203],"(p<0.001)":[161],"Hyperthermia":[169,196],"MMP-9":[172,233],"activity":[173,190,200],"occlusion":[181,209],"compared":[182,210],"normothermia":[184,212],"(p<0.05),":[185],"whereas":[186],"MMP-2":[189],"only":[194],"(p<0.05).":[195,213],"also":[197],"elevated":[198],"uPA":[199,235],"CONCLUSIONS:":[214],"These":[215],"results":[216],"demonstrate":[217],"that":[218],"exacerbates":[220],"possibly":[226],"increasing":[228],"MMP-2,":[232],"tissues.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}