{"id":"https://openalex.org/W2009776334","doi":"https://doi.org/10.1002/mc.2940140303","title":"Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors","display_name":"Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2009776334","doi":"https://doi.org/10.1002/mc.2940140303","mag":"2009776334","pmid":"https://pubmed.ncbi.nlm.nih.gov/7576106"},"language":"en","primary_location":{"id":"doi:10.1002/mc.2940140303","doi":"https://doi.org/10.1002/mc.2940140303","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.2940140303","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063939965","display_name":"Joan P. Packenham","orcid":"https://orcid.org/0000-0001-6917-9828","observed_orcids":["https://orcid.org/0000-0001-6917-9828"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan P. Packenham","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024312010","display_name":"Jack A. Taylor","orcid":"https://orcid.org/0000-0001-5303-6398","observed_orcids":["https://orcid.org/0000-0001-5303-6398"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack A. Taylor","raw_affiliation_strings":["Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109176109","display_name":"Colleen H. Anna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen H. Anna","raw_affiliation_strings":["Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046815801","display_name":"Catherine M. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. White","raw_affiliation_strings":["Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086073952","display_name":"Theodora R. Devereux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodora R. Devereux","raw_affiliation_strings":["Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024312010"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":5.5011,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95859858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"3","first_page":"147","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.32420000433921814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-tumors","display_name":"bladder tumors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chromosome-9p21","display_name":"chromosome 9p21","score":0.9660000205039978},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.8140000104904175},{"id":"https://openalex.org/keywords/p15","display_name":"p15","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.9169999957084656},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":1.0},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bladder-carcinogenesis","display_name":"bladder carcinogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9192458391189575},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7072736024856567},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.599839985370636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5320611596107483},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5260774493217468},{"id":"https://openalex.org/C150305515","wikidata":"https://www.wikidata.org/wiki/Q5253648","display_name":"Deletion mapping","level":4,"score":0.5173172950744629},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5157718658447266},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5148343443870544},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.4901455342769623},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4261695444583893},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4148319363594055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3780044913291931},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.342133104801178},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.19264864921569824},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.1708337366580963}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mc.2940140303","doi":"https://doi.org/10.1002/mc.2940140303","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.2940140303","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:7576106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7576106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1500889685","https://openalex.org/W1501631032","https://openalex.org/W1549171185","https://openalex.org/W1943334024","https://openalex.org/W1983348452","https://openalex.org/W1984127994","https://openalex.org/W1997073961","https://openalex.org/W2003907692","https://openalex.org/W2026301882","https://openalex.org/W2032118018","https://openalex.org/W2037268137","https://openalex.org/W2038124483","https://openalex.org/W2066848701","https://openalex.org/W2074067954","https://openalex.org/W2099482881","https://openalex.org/W2138544437","https://openalex.org/W2416204117","https://openalex.org/W2435472835","https://openalex.org/W6675249218"],"related_works":["https://openalex.org/W2135687675","https://openalex.org/W1967613482","https://openalex.org/W1549171185","https://openalex.org/W2140507460","https://openalex.org/W2466317016","https://openalex.org/W2259431586","https://openalex.org/W1500889685","https://openalex.org/W1943334024","https://openalex.org/W2169250920","https://openalex.org/W1987981580"],"abstract_inverted_index":{"Chromosome":[0],"9p21":[1,31],"appears":[2],"to":[3,78,133,184,205,251],"harbor":[4],"a":[5,17,153,277],"tumor":[6,40,56,259,283],"suppressor":[7,57,260,284],"gene,":[8],"as":[9,152,256],"evidenced":[10],"by":[11,53,126,139],"deletions":[12,168,187,223],"in":[13,16,32,86,102,112,122,209,215,262,268,287],"this":[14,225,237,263,288],"region":[15,51,124,138,264],"variety":[18],"of":[19,63,91,94,107,114,158,169,224,242,280,282],"human":[20,69],"primary":[21],"tumors":[22,160,182,220,233],"and":[23,41,60,73,81,88,129,180,231,239],"cell":[24],"lines.":[25],"To":[26],"map":[27,135],"the":[28,50,54,67,79,115,123,136,145,170,177,211,257],"deletion":[29,213,241,275],"at":[30,44,66,163,236],"bladder":[33,95,116,217,269],"tumors,":[34],"we":[35],"analyzed":[36],"DNA":[37],"from":[38],"28":[39],"normal":[42],"pairs":[43],"five":[45],"microsatellite":[46,198],"markers":[47,68,121,165],"that":[48,265,273],"flank":[49],"occupied":[52],"putative":[55],"genes":[58],"p16":[59,82,111,178,193,253],"p15.":[61],"Loss":[62],"heterozygosity":[64],"(LOH)":[65],"interferon":[70],"(HIFN)":[71],"alpha":[72,128,230],"D9S171,":[74],"which":[75,173],"are":[76],"adjacent":[77],"p15":[80,109,189,255],"loci,":[83],"was":[84],"detected":[85,101],"41%":[87],"33%,":[89],"respectively,":[90],"informative":[92],"cases":[93],"tumors.":[96,117,218],"No":[97],"sequence":[98],"mutations":[99],"were":[100,131],"exons":[103],"1":[104],"or":[105,110,254],"2":[106],"either":[108],"any":[113],"Three":[118],"sequence-tagged":[119],"site":[120],"bordered":[125],"HIFN":[127,146,229],"D9S171":[130],"used":[132,250],"further":[134],"deleted":[137],"multiplex":[140],"polymerase":[141],"chain":[142],"reaction":[143],"with":[144,161],"gamma":[147],"maker":[148],"(on":[149],"chromosome":[150],"12)":[151],"control":[154],"for":[155],"amplification.":[156],"Six":[157],"11":[159],"LOH":[162,235],"surrounding":[164],"had":[166],"homozygous":[167,186,222,240,274],"marker":[171,226,238],"c5.1,":[172],"is":[174,266,276],"located":[175,201],"within":[176,188],"gene;":[179],"two":[181,232],"appeared":[183],"have":[185],"(RN1.1)":[190],"but":[191,227],"not":[192,228,248],"(c5.1).":[194],"A":[195],"recently":[196],"identified":[197],"marker,":[199],"p16-CA-1,":[200],"16":[202],"kb":[203],"distal":[204],"p16,":[206],"proved":[207],"valuable":[208],"defining":[210],"minimal":[212],"involved":[214,267],"these":[216,245],"Five":[219],"exhibited":[221],"showed":[234],"p16.":[243],"Although":[244],"data":[246],"could":[247],"be":[249],"identify":[252],"definitive":[258],"gene":[261,285],"carcinogenesis,":[270],"they":[271],"suggest":[272],"common":[278],"mechanism":[279],"loss":[281],"function":[286],"region.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
