{"id":"https://openalex.org/W2009775448","doi":"https://doi.org/10.1080/03008200390181834","title":"Novel Osteoinductive Biomimetic Scaffolds Stimulate Human Osteoprogenitor Activity--Implications for Skeletal Repair","display_name":"Novel Osteoinductive Biomimetic Scaffolds Stimulate Human Osteoprogenitor Activity--Implications for Skeletal Repair","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2009775448","doi":"https://doi.org/10.1080/03008200390181834","mag":"2009775448","pmid":"https://pubmed.ncbi.nlm.nih.gov/12952215"},"language":"en","primary_location":{"id":"doi:10.1080/03008200390181834","doi":"https://doi.org/10.1080/03008200390181834","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03008200390181834","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052468363","display_name":"Xuebin Yang","orcid":"https://orcid.org/0000-0002-0144-2826","observed_orcids":["https://orcid.org/0000-0002-0144-2826","https://orcid.org/0009-0005-8291-1039","https://orcid.org/0000-0001-6133-7617"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"X. B. Yang","raw_affiliation_strings":["University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028440911","display_name":"D. W. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. W. Green","raw_affiliation_strings":["University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111620928","display_name":"H.I. Roach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. I. Roach","raw_affiliation_strings":["University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808043","display_name":"Nicholas M.P. Clarke","orcid":"https://orcid.org/0000-0002-2048-9785","observed_orcids":["https://orcid.org/0000-0002-2048-9785"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. M. P. Clarke","raw_affiliation_strings":["University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112235798","display_name":"H. Clarke Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. C. Anderson","raw_affiliation_strings":["Kansas University Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas University Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064789926","display_name":"Steven M. Howdle","orcid":"https://orcid.org/0000-0001-5901-8342","observed_orcids":["https://orcid.org/0000-0001-5901-8342"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. M. Howdle","raw_affiliation_strings":["School of Chemistry, University of Nottingham, University Park, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Nottingham, University Park, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023518920","display_name":"Kevin M. Shakesheff","orcid":"https://orcid.org/0000-0003-3236-2439","observed_orcids":["https://orcid.org/0000-0003-3236-2439"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. M. Shakesheff","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050887535","display_name":"Richard O. C. Oreffo","orcid":"https://orcid.org/0000-0001-5995-6726","observed_orcids":["https://orcid.org/0000-0001-5995-6726"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. O. C. Oreffo","raw_affiliation_strings":["University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Orthopaedics, University of Southampton, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1321,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.84732594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"1","first_page":"312","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprogenitor-cells","display_name":"osteoprogenitor cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/biomimetic-scaffolds","display_name":"biomimetic scaffolds","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5920000076293945},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cell-chemotaxis","display_name":"cell chemotaxis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cell-adhesion-and-migration","display_name":"cell adhesion and migration","score":0.7250000238418579},{"id":"https://openalex.org/keywords/3d-scaffolds","display_name":"3D scaffolds","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.7860000133514404},{"id":"https://openalex.org/keywords/new-bone-formation","display_name":"new bone formation","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.774604856967926},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7290064692497253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.688764750957489},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6824129819869995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6212038993835449},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.49501389265060425},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4428294599056244},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4288644790649414},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4273458421230316},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32146894931793213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2490767538547516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15761640667915344},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12245583534240723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05321222543716431},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/03008200390181834","doi":"https://doi.org/10.1080/03008200390181834","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03008200390181834","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},{"id":"doi:10.1080/713713599","doi":"https://doi.org/10.1080/713713599","is_oa":false,"landing_page_url":"https://doi.org/10.1080/713713599","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},{"id":"pmid:12952215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12952215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective tissue research","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:26140","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/26140/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1480928262","https://openalex.org/W1829528853","https://openalex.org/W1966218431","https://openalex.org/W1968055329","https://openalex.org/W1968822620","https://openalex.org/W1978186163","https://openalex.org/W1978456180","https://openalex.org/W1985905343","https://openalex.org/W1986469118","https://openalex.org/W2003104263","https://openalex.org/W2010137939","https://openalex.org/W2011821170","https://openalex.org/W2011913681","https://openalex.org/W2015136889","https://openalex.org/W2015668670","https://openalex.org/W2019480285","https://openalex.org/W2026406517","https://openalex.org/W2032558398","https://openalex.org/W2041917627","https://openalex.org/W2063993128","https://openalex.org/W2065479333","https://openalex.org/W2079104480","https://openalex.org/W2080949823","https://openalex.org/W2081438193","https://openalex.org/W2083242918","https://openalex.org/W2084523986","https://openalex.org/W2087764823","https://openalex.org/W2088686025","https://openalex.org/W2091513378","https://openalex.org/W2117115638","https://openalex.org/W2132111962","https://openalex.org/W2154000747","https://openalex.org/W2159999899","https://openalex.org/W2162822427","https://openalex.org/W2340065664","https://openalex.org/W2399195859","https://openalex.org/W4211147424"],"related_works":["https://openalex.org/W7054609445","https://openalex.org/W1973293639","https://openalex.org/W2072538853","https://openalex.org/W2054580039","https://openalex.org/W2390572331","https://openalex.org/W2083242918","https://openalex.org/W2015164004","https://openalex.org/W3175235528","https://openalex.org/W1980060991","https://openalex.org/W2256930516"],"abstract_inverted_index":{"The":[0,41,139],"development":[1],"of":[2,14,24,43,51,68,132,142],"new":[3],"bone":[4,26,160],"formation":[5,161],"strategies":[6],"offers":[7],"tremendous":[8],"therapeutic":[9],"implications":[10],"in":[11,28,85,120],"a":[12],"variety":[13],"musculoskeletal":[15],"diseases.":[16],"One":[17],"approach":[18],"involves":[19],"harnessing":[20],"the":[21,49,56],"regenerative":[22],"capacity":[23],"osteoprogenitor":[25,73,134],"cells":[27,70,135,153],"combination":[29],"with":[30,114],"biomimetic":[31,144],"scaffolds":[32],"generated":[33],"from":[34,151],"appropriate":[35],"scaffold":[36],"matrices":[37],"and":[38,65,87,101,124,130],"osteoinductive":[39,54,66,77,149],"factors.":[40],"aims":[42],"our":[44],"study":[45],"were":[46],"to":[47],"test":[48],"efficacy":[50],"two":[52],"innovative":[53],"agents:":[55],"osteoblast":[57],"stimulating":[58],"factor-1":[59],"(osf-1),":[60],"an":[61],"extracellular":[62],"matrix-associated":[63],"protein,":[64],"extracts":[67,123],"Saos-2":[69,75,121,152],"on":[71,136],"human":[72,133],"cells.":[74],"extracted":[76],"factors":[78,118,150],"significantly":[79,91],"stimulated":[80,92],"alkaline":[81,97,102],"phosphatase":[82,103],"specific":[83,104],"activity":[84,105],"basal":[86],"osteogenic":[88],"conditions.":[89],"Osf-1":[90],"chemotaxis,":[93],"total":[94],"colony":[95,99],"formation,":[96,100],"phosphatase-positive":[98],"at":[106],"concentrations":[107],"as":[108,110],"low":[109],"10":[111],"pg/ml":[112],"compared":[113],"control":[115],"cultures.":[116],"Osteoinductive":[117],"present":[119],"cell":[122],"osf-1":[125,147],"promoted":[126],"adhesion,":[127],"migration,":[128],"expansion,":[129],"differentiation":[131],"3-D":[137,143],"scaffolds.":[138],"successful":[140],"generation":[141],"structures":[145],"incorporating":[146],"or":[148],"indicates":[154],"their":[155],"potential":[156],"for":[157],"de":[158],"novo":[159],"that":[162],"exploits":[163],"cell-matrix":[164],"interactions.":[165]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
