{"id":"https://openalex.org/W2009772449","doi":"https://doi.org/10.1016/0020-711x(90)90180-b","title":"Lung cytochrome P450-dependent benzyloxyphenoxazone debenzylase and ethoxyphenoxazone deethylase activities in total microsomal and isolated alveolar type II cells: Responses to changes in assay conditions with special reference to non-linear dependence at low enzyme concentration","display_name":"Lung cytochrome P450-dependent benzyloxyphenoxazone debenzylase and ethoxyphenoxazone deethylase activities in total microsomal and isolated alveolar type II cells: Responses to changes in assay conditions with special reference to non-linear dependence at low enzyme concentration","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2009772449","doi":"https://doi.org/10.1016/0020-711x(90)90180-b","mag":"2009772449","pmid":"https://pubmed.ncbi.nlm.nih.gov/1691991"},"language":"en","primary_location":{"id":"doi:10.1016/0020-711x(90)90180-b","doi":"https://doi.org/10.1016/0020-711x(90)90180-b","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-711x(90)90180-b","pdf_url":null,"source":{"id":"https://openalex.org/S116532113","display_name":"International Journal of Biochemistry","issn_l":"0020-711X","issn":["0020-711X","1878-6014"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077636545","display_name":"Jean Rabovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801224436","display_name":"California Department of Health Care Services","ror":"https://ror.org/02q70n095","country_code":"US","type":"government","lineage":["https://openalex.org/I1291847170","https://openalex.org/I2801224436","https://openalex.org/I4389425283"]},{"id":"https://openalex.org/I4389425283","display_name":"State of California","ror":"https://ror.org/030sa3819","country_code":"US","type":"government","lineage":["https://openalex.org/I4389425283"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Rabovsky","raw_affiliation_strings":["California State Department of Health Services, Sacramento 95814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California State Department of Health Services, Sacramento 95814","institution_ids":["https://openalex.org/I2801224436","https://openalex.org/I4389425283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034922307","display_name":"Deloris J. Judy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.J. Judy","raw_affiliation_strings":["National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Goddard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Goddard","raw_affiliation_strings":["National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110159239","display_name":"William H. Pailes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.H. Pailes","raw_affiliation_strings":["National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114256988","display_name":"Vincent Castranova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Castranova","raw_affiliation_strings":["National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, U.S.A","institution_ids":["https://openalex.org/I198423848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6266,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58834999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"2","first_page":"171","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lung-microsomes","display_name":"lung microsomes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/enzyme-assay-conditions","display_name":"enzyme assay conditions","score":0.6019999980926514},{"id":"https://openalex.org/keywords/dicoumarol","display_name":"dicumarol","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dimyristoylphosphatidylcholine","display_name":"dimyristoylphosphatidylcholine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/enzyme-storage-stability","display_name":"enzyme storage stability","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.9225705862045288},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6815856099128723},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6278126239776611},{"id":"https://openalex.org/C2776524530","wikidata":"https://www.wikidata.org/wiki/Q4119721","display_name":"Microsoma","level":4,"score":0.5865461826324463},{"id":"https://openalex.org/C2776719974","wikidata":"https://www.wikidata.org/wiki/Q821641","display_name":"Metyrapone","level":2,"score":0.5739911794662476},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.45930397510528564},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41286277770996094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3716807961463928},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2853381037712097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19568383693695068}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001571","descriptor_name":"Benzoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001728","descriptor_name":"Dicumarol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008797","descriptor_name":"Metyrapone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013010","descriptor_name":"Sonication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0020-711x(90)90180-b","doi":"https://doi.org/10.1016/0020-711x(90)90180-b","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-711x(90)90180-b","pdf_url":null,"source":{"id":"https://openalex.org/S116532113","display_name":"International Journal of Biochemistry","issn_l":"0020-711X","issn":["0020-711X","1878-6014"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:1691991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1691991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W610054539","https://openalex.org/W1480425469","https://openalex.org/W1551113005","https://openalex.org/W1775749144","https://openalex.org/W1914568913","https://openalex.org/W1967215004","https://openalex.org/W1990165238","https://openalex.org/W1996806551","https://openalex.org/W2008980299","https://openalex.org/W2025127573","https://openalex.org/W2032225081","https://openalex.org/W2040547124","https://openalex.org/W2053536319","https://openalex.org/W2129912178","https://openalex.org/W2256880598","https://openalex.org/W2339571923","https://openalex.org/W2409050633","https://openalex.org/W3209668386","https://openalex.org/W6703970832"],"related_works":["https://openalex.org/W2409050633","https://openalex.org/W2025127573","https://openalex.org/W3209668386","https://openalex.org/W1966805986","https://openalex.org/W2026464316","https://openalex.org/W2040055155","https://openalex.org/W1986805574","https://openalex.org/W2093401853","https://openalex.org/W1964065398","https://openalex.org/W1978013472"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
