{"id":"https://openalex.org/W2009759690","doi":"https://doi.org/10.1021/jo9600621","title":"Framework-Reactive Siderophore Analogs as Potential Cell-Selective Drugs. Design and Syntheses of Trimelamol-Based Iron Chelators","display_name":"Framework-Reactive Siderophore Analogs as Potential Cell-Selective Drugs. Design and Syntheses of Trimelamol-Based Iron Chelators","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2009759690","doi":"https://doi.org/10.1021/jo9600621","mag":"2009759690","pmid":"https://pubmed.ncbi.nlm.nih.gov/11667292"},"language":"en","primary_location":{"id":"doi:10.1021/jo9600621","doi":"https://doi.org/10.1021/jo9600621","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo9600621","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029870688","display_name":"Savithri Ramurthy","orcid":"https://orcid.org/0000-0002-2444-5309","observed_orcids":["https://orcid.org/0000-0002-2444-5309"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Savithri Ramurthy","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091265699","display_name":"Marvin J. Miller","orcid":"https://orcid.org/0000-0002-3704-8214","observed_orcids":["https://orcid.org/0000-0002-3704-8214"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin J. Miller","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.5939,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.69362587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"61","issue":"12","first_page":"4120","last_page":"4124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.24899999797344208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.24899999797344208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.11649999767541885,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hydroxamic-acids","display_name":"hydroxamic acids","score":0.8259999752044678},{"id":"https://openalex.org/keywords/iminium-ions","display_name":"iminium ions","score":0.7910000085830688},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6119999885559082},{"id":"https://openalex.org/keywords/antimicrobial-agents","display_name":"antimicrobial agents","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C108319773","wikidata":"https://www.wikidata.org/wiki/Q424747","display_name":"Siderophore","level":3,"score":0.8827378749847412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5485544800758362},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5054490566253662},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.4567282795906067},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4185140132904053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37289339303970337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2434423565864563},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13717064261436462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/jo9600621","doi":"https://doi.org/10.1021/jo9600621","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo9600621","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:11667292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11667292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W189585810","https://openalex.org/W1965032920","https://openalex.org/W1966649585","https://openalex.org/W1998359748","https://openalex.org/W2001906467","https://openalex.org/W2010366908","https://openalex.org/W2011844783","https://openalex.org/W2023794915","https://openalex.org/W2034863843","https://openalex.org/W2038102698","https://openalex.org/W2049011959","https://openalex.org/W2052074908","https://openalex.org/W2076234505","https://openalex.org/W2078337870","https://openalex.org/W2113275754","https://openalex.org/W2346444042","https://openalex.org/W2949509569","https://openalex.org/W2951467009","https://openalex.org/W2952746520","https://openalex.org/W4232403869"],"related_works":["https://openalex.org/W4230748041","https://openalex.org/W2952746520","https://openalex.org/W2997727609","https://openalex.org/W1999456754","https://openalex.org/W2020759392","https://openalex.org/W2079133096","https://openalex.org/W6903775729","https://openalex.org/W2039654504","https://openalex.org/W2950657702","https://openalex.org/W4394676211"],"abstract_inverted_index":{"Currently,":[0],"the":[1,18,45,54,62,81,113,118,137],"role":[2],"of":[3,13,17,56,67,69,85,99,117,140,144],"DNA-directed":[4],"alkylating":[5,19],"agents":[6,20],"as":[7,23],"potential":[8,139],"anticancer/":[9],"antimicrobial":[10],"drugs":[11,24],"is":[12],"wide":[14],"interest.":[15],"Most":[16],"used":[21],"clinically":[22],"damage":[25],"DNA":[26],"in":[27],"cells":[28],"without":[29],"specificity,":[30],"and":[31,64,75,96,104,115,148],"this":[32,141],"can":[33],"lead":[34],"to":[35,47],"undesired":[36],"toxicity":[37],"problems.":[38],"Minimizing":[39],"serum":[40],"residence":[41],"time":[42],"by":[43],"targeting":[44],"drug":[46,146],"select":[48],"pathogens":[49],"or":[50,109],"organs":[51],"might":[52],"diminish":[53],"effects":[55],"nonselective":[57],"reactivity.":[58],"This":[59],"paper":[60],"describes":[61],"syntheses":[63],"preliminary":[65,121],"studies":[66],"analogs":[68],"siderophores":[70],"(microbial":[71],"iron":[72],"chelators)":[73],"2":[74],"20":[76],"that":[77],"incorporate":[78],"centers":[79],"within":[80],"siderophore":[82,128],"framework":[83],"capable":[84],"generating":[86],"potent":[87],"electrophiles":[88],"(iminium":[89],"ions),":[90],"hopefully":[91],"after":[92],"directed":[93],"cellular":[94],"recognition":[95],"uptake.":[97],"Formation":[98],"N-aminals":[100],"from":[101],"trimelamol":[102],"(3)":[103],"substituted":[105],"hydroxamic":[106],"acid":[107],"4":[108],"5was":[110],"critical":[111],"for":[112],"design":[114,147],"synthesis":[116],"targets.":[119],"In":[120],"biological":[122],"testing,":[123],"compound":[124],"2,":[125],"a":[126],"trimelamol-based":[127],"analog,":[129],"was":[130],"active":[131],"against":[132],"Escherichia":[133],"coli":[134],"X580,":[135],"illustrating":[136],"therapeutic":[138],"new":[142],"type":[143],"siderophore-mediated":[145],"delivery.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}