{"id":"https://openalex.org/W2009737277","doi":"https://doi.org/10.1159/000207074","title":"Characteristics of Peripheral Blood Monocytes in Hereditary Xerocytosis and Spherocytosis","display_name":"Characteristics of Peripheral Blood Monocytes in Hereditary Xerocytosis and Spherocytosis","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2009737277","doi":"https://doi.org/10.1159/000207074","mag":"2009737277","pmid":"https://pubmed.ncbi.nlm.nih.gov/6810626"},"language":"en","primary_location":{"id":"doi:10.1159/000207074","doi":"https://doi.org/10.1159/000207074","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000207074","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113205567","display_name":"L. Michael Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.M. Snyder","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013609861","display_name":"Laszlo Leb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Leb","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109573195","display_name":"Jerome B. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.B. Jacobs","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699027","display_name":"Normand L. Fortier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.L. Fortier","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Reeves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Reeves","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L.L. Neri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800713431","display_name":"Saint Vincent Hospital","ror":"https://ror.org/004350h06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800713431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.L. Neri","raw_affiliation_strings":["Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Department of Pathology, St. Vincent Hospital, Worcester, Mass., USA","institution_ids":["https://openalex.org/I2800713431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022050277","display_name":"M.St. John","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.St. John","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17083116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"4","first_page":"268","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-xerocytosis","display_name":"hereditary xerocytosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/hereditary-spherocytosis","display_name":"hereditary spherocytosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/peripheral-blood-monocytes","display_name":"peripheral blood monocytes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/congenital-hemolytic-anemia","display_name":"congenital hemolytic anemia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/red-cell-fragmentation","display_name":"red cell fragmentation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/monocyte-morphology","display_name":"monocyte morphology","score":0.6980000138282776},{"id":"https://openalex.org/keywords/co2-emissions","display_name":"CO2 emissions","score":0.6589999794960022},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/esterase-activity","display_name":"esterase activity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/monocyte-chemotaxis","display_name":"monocyte chemotaxis","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2776952295","wikidata":"https://www.wikidata.org/wiki/Q541244","display_name":"Hereditary spherocytosis","level":2,"score":0.7378085851669312},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.7312844395637512},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5186797380447388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4505850672721863},{"id":"https://openalex.org/C2779245863","wikidata":"https://www.wikidata.org/wiki/Q11181178","display_name":"Spherocytosis","level":4,"score":0.4418477416038513},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4405818581581116},{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.4236804246902466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34482577443122864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3097638189792633},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.30769431591033936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2479584813117981},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.15505486726760864},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.11452323198318481}],"mesh":[{"descriptor_ui":"D000745","descriptor_name":"Anemia, Hemolytic, Congenital","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000745","descriptor_name":"Anemia, Hemolytic, Congenital","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000745","descriptor_name":"Anemia, Hemolytic, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006600","descriptor_name":"Hexosephosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000207074","doi":"https://doi.org/10.1159/000207074","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000207074","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:6810626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6810626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1855643240","display_name":"MEMBRANE AND RED CELL DYSFUNCTION IN HEMOLYTIC ANEMIA","funder_award_id":"R01HL019933","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7120448173","https://openalex.org/W2563270072","https://openalex.org/W1580168126","https://openalex.org/W4417018177","https://openalex.org/W2010545296","https://openalex.org/W2460648598","https://openalex.org/W4416175599","https://openalex.org/W2412164697","https://openalex.org/W4389235145","https://openalex.org/W1966602463"],"abstract_inverted_index":{"Peripheral":[0],"blood":[1,130],"monocytes":[2,31,54,102,120],"isolated":[3],"from":[4,50],"patients":[5],"with":[6,107],"congenital":[7],"hemolytic":[8,104],"anemia,":[9],"hereditary":[10],"xerocytosis":[11],"and":[12,21,42,64,121],"spherocytosis,":[13],"demonstrated":[14],"in":[15,35,52,75,103,109],"vivo":[16],"engulfment":[17],"of":[18,47,62,78],"red":[19,111,129],"cell":[20,112,131],"platelet":[22],"fragments.":[23],"In":[24],"addition,":[25],"morphometric":[26],"studies":[27],"performed":[28],"on":[29],"these":[30],"showed":[32],"an":[33],"increase":[34],"cytoplasmic/nuclear":[36],"ratio":[37],"as":[38,40],"well":[39],"lysosome":[41],"phagosome":[43],"volumes.":[44],"The":[45],"production":[46],"carbon":[48],"dioxide":[49],"glucose-1-14C":[51],"abnormal":[53],"was":[55,81],"increased":[56,84,108],"(15-80%)":[57],"but":[58],"the":[59,76,101,118],"intracellular":[60],"values":[61],"beta-glucuronidase":[63],"esterase":[65],"activity":[66],"were":[67],"similar":[68],"to":[69,128],"control":[70,96],"monocytes.":[71],"Monocyte":[72],"locomotion":[73],"assessed":[74],"presence":[77],"chemotactic":[79],"stimuli":[80],"found":[82],"significantly":[83],"(73":[85],"+/-":[86,93],"12":[87],"monocytes/oil":[88],"immersion":[89],"fields":[90],"vs.":[91],"46":[92],"5":[94],"for":[95],"monocytes).":[97],"We":[98],"concluded":[99],"that":[100,122],"anemias":[105],"associated":[106],"vitro":[110],"fragmentation":[113],"have":[114],"some":[115],"features":[116],"resembling":[117],"'stimulated'":[119],"this":[123],"alteration":[124],"may":[125],"be":[126],"due":[127],"fragment":[132],"ingestion.":[133]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}