{"id":"https://openalex.org/W2009705332","doi":"https://doi.org/10.1073/pnas.1220552110","title":"Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate","display_name":"Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate","publication_year":2013,"publication_date":"2013-06-24","ids":{"openalex":"https://openalex.org/W2009705332","doi":"https://doi.org/10.1073/pnas.1220552110","mag":"2009705332","pmid":"https://pubmed.ncbi.nlm.nih.gov/23798435","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3710838"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1220552110","doi":"https://doi.org/10.1073/pnas.1220552110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1220552110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3710838","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054976873","display_name":"Florian Buchmayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Florian Buchmayer","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021691520","display_name":"Klaus W. Schicker","orcid":"https://orcid.org/0000-0002-3068-7830","observed_orcids":["https://orcid.org/0000-0002-3068-7830"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Klaus Schicker","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034351718","display_name":"Thomas Steinkellner","orcid":"https://orcid.org/0000-0003-4591-4992","observed_orcids":["https://orcid.org/0000-0003-4591-4992"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Steinkellner","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057842619","display_name":"Petra Geier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Petra Geier","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086068010","display_name":"Gerald St\u00fcbiger","orcid":"https://orcid.org/0000-0002-7128-8158","observed_orcids":["https://orcid.org/0000-0002-7128-8158"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerald St\u00fcbiger","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102810342","display_name":"Peter J. Hamilton","orcid":"https://orcid.org/0000-0002-6819-8346","observed_orcids":["https://orcid.org/0000-0002-6819-8346"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Hamilton","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067111570","display_name":"Andreas Jurik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Jurik","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","cDepartment of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"cDepartment of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038910133","display_name":"Thomas Stockner","orcid":"https://orcid.org/0000-0002-7071-8283","observed_orcids":["https://orcid.org/0000-0002-7071-8283"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Stockner","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090559484","display_name":"Jae\u2010Won Yang","orcid":"https://orcid.org/0000-0001-8928-0130","observed_orcids":["https://orcid.org/0000-0001-8928-0130"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Jae-Won Yang","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022573604","display_name":"Therese Montgomery","orcid":"https://orcid.org/0000-0003-2749-5376","observed_orcids":["https://orcid.org/0000-0003-2749-5376"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","IE"],"is_corresponding":false,"raw_author_name":"Therese Montgomery","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland","dSchool of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"dSchool of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046497020","display_name":"Marion Holy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Marion Holy","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033902973","display_name":"Tina Hofmaier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Tina Hofmaier","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050428979","display_name":"Oliver Kudlacek","orcid":"https://orcid.org/0000-0002-3086-8551","observed_orcids":["https://orcid.org/0000-0002-3086-8551"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Oliver Kudlacek","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021766108","display_name":"Heinrich J. G. Matthies","orcid":"https://orcid.org/0000-0003-3615-7571","observed_orcids":["https://orcid.org/0000-0003-3615-7571"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinrich J. G. Matthies","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014396881","display_name":"Gerhard Franz Ecker","orcid":"https://orcid.org/0000-0003-4209-6883","observed_orcids":["https://orcid.org/0000-0003-4209-6883"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerhard F. Ecker","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","cDepartment of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"cDepartment of Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria; and","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106858397","display_name":"Valery Bochkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Valery Bochkov","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019043893","display_name":"Aurelio Galli","orcid":"https://orcid.org/0000-0001-7173-9345","observed_orcids":["https://orcid.org/0000-0001-7173-9345"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aurelio Galli","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"bDepartment of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center, Vanderbilt University, Nashville, TN 37013;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029101014","display_name":"Stefan Boehm","orcid":"https://orcid.org/0000-0002-0205-2459","observed_orcids":["https://orcid.org/0000-0002-0205-2459"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan Boehm","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079264101","display_name":"Harald H. Sitte","orcid":"https://orcid.org/0000-0002-1339-7444","observed_orcids":["https://orcid.org/0000-0002-1339-7444"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Harald H. Sitte","raw_affiliation_strings":["Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"aCenter of Physiology and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":{"value":792,"currency":"EUR","value_usd":854},"fwci":2.3701,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.87725069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"110","issue":"28","first_page":"11642","last_page":"11647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/amphetamine","display_name":"amphetamine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8740000128746033},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.5170000195503235},{"id":"https://openalex.org/keywords/serotonin-efflux","display_name":"serotonin efflux","score":0.7609999775886536},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.8410000205039978},{"id":"https://openalex.org/keywords/monoamine-transporters","display_name":"monoamine transporters","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pip2-binding-site","display_name":"PIP2 binding site","score":0.8199999928474426},{"id":"https://openalex.org/keywords/stimulant-dependence","display_name":"stimulant use disorder","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.7148897647857666},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.6963008642196655},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.6890592575073242},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6311641335487366},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6082286834716797},{"id":"https://openalex.org/C16696662","wikidata":"https://www.wikidata.org/wiki/Q17079236","display_name":"Neurotransmitter transporter","level":4,"score":0.5101547837257385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4873960614204407},{"id":"https://openalex.org/C2777853560","wikidata":"https://www.wikidata.org/wiki/Q3083814","display_name":"Phosphatidylinositol 4,5-bisphosphate","level":4,"score":0.47274813055992126},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.43537279963493347},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4201869070529938},{"id":"https://openalex.org/C2909816965","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine Plasma Membrane Transport Proteins","level":5,"score":0.41770148277282715},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.4114207625389099},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38639843463897705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36991173028945923},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36781764030456543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36185064911842346},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3532736897468567},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.3368091583251953},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2904469966888428},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.2615364193916321},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23519739508628845},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12094515562057495},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10911816358566284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1220552110","doi":"https://doi.org/10.1073/pnas.1220552110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1220552110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2716774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3710838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23798435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23798435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3710838","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3710838/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2716774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3710838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2355907517","display_name":"Amphetamine Regulation of Dopamine Transport","funder_award_id":"R01DA013975","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3333407392","display_name":null,"funder_award_id":"DA-13975","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4567703735","display_name":"Amphetamine Regulation of Dopamine Transport","funder_award_id":"R56DA013975","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7676086491","display_name":"Dopamine Transporter Interactions: Understanding Transporter Function","funder_award_id":"F31DA035535","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W108431095","https://openalex.org/W1709672860","https://openalex.org/W1964622351","https://openalex.org/W1964672651","https://openalex.org/W1970124769","https://openalex.org/W1970870670","https://openalex.org/W1972943445","https://openalex.org/W1985179998","https://openalex.org/W1996599358","https://openalex.org/W2000994188","https://openalex.org/W2003203666","https://openalex.org/W2004579306","https://openalex.org/W2017557863","https://openalex.org/W2023333551","https://openalex.org/W2036629661","https://openalex.org/W2046508842","https://openalex.org/W2049695640","https://openalex.org/W2050529989","https://openalex.org/W2054927476","https://openalex.org/W2056189730","https://openalex.org/W2071786252","https://openalex.org/W2089781399","https://openalex.org/W2090374527","https://openalex.org/W2090493398","https://openalex.org/W2091649030","https://openalex.org/W2091884933","https://openalex.org/W2093048098","https://openalex.org/W2093272212","https://openalex.org/W2097845013","https://openalex.org/W2113009216","https://openalex.org/W2118141613","https://openalex.org/W2121091224","https://openalex.org/W2146414809","https://openalex.org/W2153841101","https://openalex.org/W2167569489","https://openalex.org/W2340043466","https://openalex.org/W2463124562","https://openalex.org/W4246091758","https://openalex.org/W4300181779"],"related_works":["https://openalex.org/W829086714","https://openalex.org/W4389025985","https://openalex.org/W3097906524","https://openalex.org/W2885016615","https://openalex.org/W3176650286","https://openalex.org/W2734409004","https://openalex.org/W1572818951","https://openalex.org/W1883856876","https://openalex.org/W2015068634","https://openalex.org/W1567634231"],"abstract_inverted_index":{"Nerve":[0],"functions":[1,86],"require":[2],"phosphatidylinositol-4,5-bisphosphate":[3],"(PIP2)":[4],"that":[5,208],"binds":[6],"to":[7,19,135,162,211,232,244],"ion":[8],"channels,":[9],"thereby":[10],"controlling":[11],"their":[12],"gating.":[13],"Channel":[14],"properties":[15],"are":[16],"also":[17,139],"attributed":[18],"serotonin":[20,37,46],"transporters":[21,144,213],"(SERTs);":[22],"however,":[23],"SERT":[24,85,95,159,240],"regulation":[25],"by":[26,35,52,62,155],"PIP2":[27,61,82,97,103,156,209],"has":[28],"not":[29,153],"been":[30],"reported.":[31],"SERTs":[32],"control":[33],"neurotransmission":[34],"removing":[36],"from":[38,48],"the":[39,58,75,78,173,230],"extracellular":[40,45],"space.":[41],"An":[42],"increase":[43],"in":[44,87,98,146,176],"results":[47,228],"transporter-mediated":[49],"efflux":[50,133,182],"triggered":[51],"amphetamine-like":[53],"psychostimulants.":[54],"Herein,":[55],"we":[56],"altered":[57],"abundance":[59],"of":[60,77,81,119,131,172,179,190,238],"activating":[63],"phospholipase-C":[64],"(PLC),":[65],"using":[66],"a":[67,124,164,177,188,215,222],"scavenging":[68],"peptide,":[69],"and":[70,96,145,183,195,202,242],"inhibiting":[71],"PIP2-synthesis.":[72],"We":[73,90],"tested":[74],"effects":[76],"verified":[79],"scarcity":[80],"on":[83],"amphetamine-triggered":[84],"human":[88],"cells.":[89],"observed":[91],"an":[92],"interaction":[93],"between":[94,200],"pull-down":[99],"assays.":[100],"On":[101],"decreased":[102],"availability,":[104],"amphetamine-evoked":[105],"currents":[106],"were":[107,198],"markedly":[108],"reduced":[109],"compared":[110],"with":[111,141],"controls,":[112],"as":[113,123,185,187],"was":[114,121,138,152,160],"amphetamine-induced":[115,180,234],"efflux.":[116],"Signaling":[117],"downstream":[118],"PLC":[120,136],"excluded":[122],"cause":[125],"for":[126,169,217,224],"these":[127],"effects.":[128,192],"A":[129],"reduction":[130],"substrate":[132],"due":[134],"activation":[137],"found":[140],"recombinant":[142],"noradrenaline":[143],"rat":[147],"hippocampal":[148],"slices.":[149],"Transmitter":[150],"uptake":[151,194],"affected":[154],"reduction.":[157],"Moreover,":[158],"revealed":[161],"have":[163],"positively":[165],"charged":[166],"binding":[167,210],"site":[168],"PIP2.":[170],"Mutation":[171],"latter":[174],"resulted":[175],"loss":[178],"SERT-mediated":[181],"currents,":[184],"well":[186],"lack":[189],"PIP2-dependent":[191],"Substrate":[193],"surface":[196],"expression":[197],"comparable":[199],"mutant":[201],"WT":[203],"SERTs.":[204],"These":[205,227],"findings":[206],"demonstrate":[207],"monoamine":[212],"is":[214],"prerequisite":[216],"amphetamine":[218],"actions":[219,236],"without":[220],"being":[221],"requirement":[223],"neurotransmitter":[225],"uptake.":[226],"open":[229],"way":[231],"target":[233],"SERT-dependent":[235],"independently":[237],"normal":[239],"function":[241],"thus":[243],"treat":[245],"psychostimulant":[246],"addiction.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}