{"id":"https://openalex.org/W2009684692","doi":"https://doi.org/10.1021/bi0606896","title":"Structural Requirements for Cellular Uptake and Antisense Activity of Peptide Nucleic Acids Conjugated with Various Peptides","display_name":"Structural Requirements for Cellular Uptake and Antisense Activity of Peptide Nucleic Acids Conjugated with Various Peptides","publication_year":2006,"publication_date":"2006-11-18","ids":{"openalex":"https://openalex.org/W2009684692","doi":"https://doi.org/10.1021/bi0606896","mag":"2009684692","pmid":"https://pubmed.ncbi.nlm.nih.gov/17154532"},"language":"en","primary_location":{"id":"doi:10.1021/bi0606896","doi":"https://doi.org/10.1021/bi0606896","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0606896","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063773966","display_name":"Yvonne Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Yvonne Wolf","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073176771","display_name":"S. Pritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Stephan Pritz","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061159142","display_name":"Sa\u00efd Abes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Sa\u00efd Abes","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044528263","display_name":"Michael Bienert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Michael Bienert","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069624232","display_name":"Bernard Lebleu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Bernard Lebleu","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076969516","display_name":"Johannes Oehlke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099563","display_name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie","ror":"https://ror.org/010s54n03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210099563"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Johannes Oehlke","raw_affiliation_strings":["Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Molecular Pharmacology, Robert-R\u00f6ssle-Strasse 10, D-13125 Berlin, Germany, and UMR 5124 CNRS, Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, 34095 Montpellier, France","institution_ids":["https://openalex.org/I4210099563","https://openalex.org/I4387154756"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3685,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93364969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"45","issue":"50","first_page":"14944","last_page":"14954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-nucleic-acid","display_name":"peptide nucleic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pna-peptide-conjugates","display_name":"PNA-peptide conjugates","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cryptic-splice-site","display_name":"cryptic splice site","score":0.8539999723434448},{"id":"https://openalex.org/keywords/amphiphilic-peptides","display_name":"peptide amphiphiles","score":0.8799999952316284},{"id":"https://openalex.org/keywords/peptide-charge","display_name":"peptide charge","score":0.5440000295639038},{"id":"https://openalex.org/keywords/peptide-helicity","display_name":"peptide helicity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cell-delivery","display_name":"cell delivery","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.8009206652641296},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.6836088299751282},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.651966392993927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5657612681388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5553895235061646},{"id":"https://openalex.org/C2777343594","wikidata":"https://www.wikidata.org/wiki/Q412152","display_name":"Peptide nucleic acid","level":3,"score":0.45280930399894714},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4250189960002899},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13623571395874023},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0866561233997345},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi0606896","doi":"https://doi.org/10.1021/bi0606896","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0606896","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:17154532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17154532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W428907568","https://openalex.org/W1584683177","https://openalex.org/W1973867068","https://openalex.org/W1979752155","https://openalex.org/W1987194067","https://openalex.org/W1989410545","https://openalex.org/W2002514150","https://openalex.org/W2003662832","https://openalex.org/W2006998980","https://openalex.org/W2018848384","https://openalex.org/W2019332937","https://openalex.org/W2029346749","https://openalex.org/W2070295920","https://openalex.org/W2071353829","https://openalex.org/W2072581984","https://openalex.org/W2076880106","https://openalex.org/W2077102218","https://openalex.org/W2111994795","https://openalex.org/W2114680905","https://openalex.org/W2169662921","https://openalex.org/W3147714897","https://openalex.org/W4245676270"],"related_works":["https://openalex.org/W2018848384","https://openalex.org/W2067122393","https://openalex.org/W2057969346","https://openalex.org/W2058098955","https://openalex.org/W2097826502","https://openalex.org/W258195840","https://openalex.org/W2162206996","https://openalex.org/W4404250395","https://openalex.org/W4242173402","https://openalex.org/W2040616318"],"abstract_inverted_index":{"Peptide":[0],"nucleic":[1],"acids":[2],"(PNAs)":[3],"have":[4,30],"shown":[5],"great":[6],"promise":[7],"as":[8,48,50,57,150,152,230],"potential":[9],"antisense":[10,172,222],"drugs;":[11],"however,":[12],"poor":[13],"cellular":[14],"delivery":[15,20],"limits":[16],"their":[17],"applications.":[18],"Improved":[19],"into":[21,91],"mammalian":[22],"cells":[23],"and":[24,61,130,136,154,202],"enhanced":[25],"biological":[26],"activity":[27],"of":[28,45,53,81,139,156,167,191,211,225,240],"PNAs":[29],"been":[31,89],"achieved":[32],"by":[33],"coupling":[34],"to":[35,76,100,128,217,247],"cell-penetrating":[36,110],"peptides":[37,47],"(CPPs).":[38],"Structural":[39],"requirements":[40],"for":[41,163,220],"the":[42,54,58,69,77,104,109,134,137,140,157,209,212,236,244],"shuttling":[43],"ability":[44],"these":[46],"well":[49,151],"structural":[51],"properties":[52],"conjugates":[55,185],"such":[56,229],"linker":[59],"type":[60],"peptide":[62,105,113,121,142,159,214],"position":[63],"remained":[64],"controversial,":[65],"so":[66],"far.":[67],"In":[68],"present":[70],"study":[71],"an":[72],"18mer":[73],"PNA":[74,203],"targeted":[75],"cryptic":[78],"splice":[79],"site":[80],"a":[82,92,196],"mutated":[83],"beta-globin":[84],"intron":[85],"2,":[86],"which":[87,123],"had":[88],"inserted":[90],"luciferase":[93],"reporter":[94],"gene":[95],"coding":[96],"sequence,":[97],"was":[98,124,160,174],"coupled":[99],"various":[101],"peptides.":[102],"As":[103],"lead":[106],"we":[107],"used":[108],"alpha-helical":[111],"amphipathic":[112,120],"KLAL":[114,115],"KAL":[116],"KAAL":[117],"KLA-NH2":[118],"[model":[119],"(MAP)]":[122],"varied":[125],"with":[126],"respect":[127],"charge":[129,149],"structure-forming":[131],"properties.":[132],"Furthermore,":[133],"linkage":[135],"localization":[138],"attached":[141,213],"(C-":[143],"vs":[144],"N-terminal)":[145],"were":[146,186],"modified.":[147],"Positive":[148],"helicity":[153],"amphipathicity":[155],"KLA":[158],"all":[161],"required":[162],"efficient":[164,188],"dose-dependent":[165],"correction":[166,190,238],"aberrant":[168,192],"splicing.":[169],"The":[170],"highest":[171],"effect":[173],"reached":[175],"within":[176],"4":[177],"h":[178],"without":[179],"any":[180],"transfection":[181],"agent.":[182],"Stably":[183],"linked":[184],"also":[187],"in":[189,250],"splicing,":[193],"suggesting":[194],"that":[195],"cleavable":[197],"disulfide":[198],"bond":[199],"between":[200],"CPP":[201],"is":[204],"clearly":[205],"not":[206],"essential.":[207],"Moreover,":[208],"placement":[210],"turned":[215],"out":[216],"be":[218,248],"crucial":[219],"attaining":[221],"activity.":[223],"Coadministration":[224],"endosome":[226],"disrupting":[227],"agents":[228],"chloroquine":[231],"or":[232],"Ca2+":[233],"significantly":[234],"increased":[235],"splicing":[237],"efficiency":[239],"some":[241],"conjugates,":[242],"indicating":[243],"predominant":[245],"portion":[246],"sequestered":[249],"vesicular":[251],"compartments.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
