{"id":"https://openalex.org/W2009598629","doi":"https://doi.org/10.1016/j.exer.2003.12.005","title":"TIMP-1 role in protection against Pseudomonas aeruginosa-induced corneal destruction","display_name":"TIMP-1 role in protection against Pseudomonas aeruginosa-induced corneal destruction","publication_year":2004,"publication_date":"2004-04-03","ids":{"openalex":"https://openalex.org/W2009598629","doi":"https://doi.org/10.1016/j.exer.2003.12.005","mag":"2009598629","pmid":"https://pubmed.ncbi.nlm.nih.gov/15109922"},"language":"en","primary_location":{"id":"doi:10.1016/j.exer.2003.12.005","doi":"https://doi.org/10.1016/j.exer.2003.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exer.2003.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058464408","display_name":"Karen A. Kernacki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karen A Kernacki","raw_affiliation_strings":["Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA. kkernack@med.wayne.edu","Department of Anatomy/Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA. kkernack@med.wayne.edu","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Anatomy/Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027165045","display_name":"John L. Chunta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L Chunta","raw_affiliation_strings":["Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114035051","display_name":"Ronald P. Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P Barrett","raw_affiliation_strings":["Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053675854","display_name":"Linda D. Hazlett","orcid":"https://orcid.org/0000-0003-1530-3242","observed_orcids":["https://orcid.org/0000-0003-1530-3242"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda D Hazlett","raw_affiliation_strings":["Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy/Cell Biology, Wayne State University-School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058464408"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":null,"fwci":0.4159,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60225276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"78","issue":"6","first_page":"1155","last_page":"1162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9610000252723694},{"id":"https://openalex.org/keywords/corneal-infection","display_name":"corneal infection","score":0.8399999737739563},{"id":"https://openalex.org/keywords/basement-membrane-integrity","display_name":"basement membrane integrity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9819999933242798},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.5960000157356262},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.765140175819397},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.748992919921875},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6448377370834351},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6146969199180603},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.604091465473175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5110224485397339},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.49003493785858154},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4896431565284729},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.4834381341934204},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4825265109539032},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4514278173446655},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.44651663303375244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4229477643966675},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34010690450668335},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3325364589691162},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32650983333587646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20275193452835083},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14322546124458313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.136710524559021},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07246562838554382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003320","descriptor_name":"Corneal Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003320","descriptor_name":"Corneal Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exer.2003.12.005","doi":"https://doi.org/10.1016/j.exer.2003.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exer.2003.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},{"id":"pmid:15109922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15109922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W13492587","https://openalex.org/W39152348","https://openalex.org/W39894470","https://openalex.org/W48705916","https://openalex.org/W54476316","https://openalex.org/W64749251","https://openalex.org/W104037594","https://openalex.org/W111517273","https://openalex.org/W118250415","https://openalex.org/W147209958","https://openalex.org/W163554593","https://openalex.org/W172474070","https://openalex.org/W1594774706","https://openalex.org/W1642011778","https://openalex.org/W1743570032","https://openalex.org/W1898218638","https://openalex.org/W1964147685","https://openalex.org/W1965824309","https://openalex.org/W1977733289","https://openalex.org/W1981323825","https://openalex.org/W2010772007","https://openalex.org/W2014447715","https://openalex.org/W2041369649","https://openalex.org/W2042323376","https://openalex.org/W2046038923","https://openalex.org/W2058567144","https://openalex.org/W2059209839","https://openalex.org/W2074206328","https://openalex.org/W2079448855","https://openalex.org/W2094112735","https://openalex.org/W2103032270","https://openalex.org/W2113362104","https://openalex.org/W2160719127","https://openalex.org/W2413889842","https://openalex.org/W3171716376","https://openalex.org/W6604167454","https://openalex.org/W6605966600"],"related_works":["https://openalex.org/W147209958","https://openalex.org/W902953014","https://openalex.org/W2118124944","https://openalex.org/W2022932509","https://openalex.org/W2035969879","https://openalex.org/W2046511939","https://openalex.org/W7097052409","https://openalex.org/W2046442794","https://openalex.org/W2096970017","https://openalex.org/W176677130"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}