{"id":"https://openalex.org/W2009596611","doi":"https://doi.org/10.1007/s11670-005-0061-y","title":"Signal mechanism of inhibition of bifidobacteria on growth of colon cancer","display_name":"Signal mechanism of inhibition of bifidobacteria on growth of colon cancer","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2009596611","doi":"https://doi.org/10.1007/s11670-005-0061-y","mag":"2009596611"},"language":"en","primary_location":{"id":"doi:10.1007/s11670-005-0061-y","doi":"https://doi.org/10.1007/s11670-005-0061-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11670-005-0061-y","pdf_url":null,"source":{"id":"https://openalex.org/S26659863","display_name":"Chinese Journal of Cancer Research","issn_l":"1000-9604","issn":["1000-9604","1993-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","oarl","poland-100"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069757838","display_name":"Jianyi Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-yi Dai","raw_affiliation_strings":["Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]},{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713993","display_name":"Lisheng Wang","orcid":"https://orcid.org/0000-0001-5965-308X","observed_orcids":["https://orcid.org/0000-0001-5965-308X"]},"institutions":[{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-sheng Wang","raw_affiliation_strings":["Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]},{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101003541","display_name":"Huiming Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-ming Zhu","raw_affiliation_strings":["Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, 518020, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]},{"raw_affiliation_string":"Department of Gastroenterology, Shenzhen Municipal People\u2019s Hospital, Shenzhen","institution_ids":["https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling-jia Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-jia Pan","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","Department of Gastroenterology, Nanfang Hospital, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101452738","display_name":"Xiaodong Ma","orcid":"https://orcid.org/0000-0001-8546-5752","observed_orcids":["https://orcid.org/0000-0001-8546-5752"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-dong Ma","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","Department of Gastroenterology, Nanfang Hospital, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101815765","display_name":"Yali Zhang","orcid":"https://orcid.org/0000-0002-4747-9739","observed_orcids":["https://orcid.org/0000-0002-4747-9739"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-li Zhang","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","Department of Gastroenterology, Nanfang Hospital, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109139153","display_name":"Dian-Yuan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dian-yuan Zhou","raw_affiliation_strings":["Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","Department of Gastroenterology, Nanfang Hospital, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, 510515, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Department of Gastroenterology, Nanfang Hospital, Guangzhou","institution_ids":["https://openalex.org/I4210103346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069757838"],"corresponding_institution_ids":["https://openalex.org/I4210105608"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13064628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"145","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9589999914169312},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8519999980926514},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9800000190734863},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9419999718666077},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9959999918937683},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.7689999938011169},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.5820000171661377},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.6617909669876099},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6230653524398804},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.562491238117218},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5406714081764221},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5050950646400452},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4994239807128906},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44775718450546265},{"id":"https://openalex.org/C2779087070","wikidata":"https://www.wikidata.org/wiki/Q5005943","display_name":"c-jun","level":4,"score":0.43630489706993103},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4304826259613037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42558497190475464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40943753719329834},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4041218161582947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35587501525878906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33802956342697144},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3219013810157776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22871321439743042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13009655475616455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0869218111038208},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08388835191726685},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s11670-005-0061-y","doi":"https://doi.org/10.1007/s11670-005-0061-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11670-005-0061-y","pdf_url":null,"source":{"id":"https://openalex.org/S26659863","display_name":"Chinese Journal of Cancer Research","issn_l":"1000-9604","issn":["1000-9604","1993-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","oarl","poland-100"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Cancer Research","raw_type":"journal-article"},{"id":"mag:1557740177","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85190X/200502/16014778.html","pdf_url":null,"source":{"id":"https://openalex.org/S26659863","display_name":"Chinese Journal of Cancer Research","issn_l":"1000-9604","issn":["1000-9604","1993-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","oarl","poland-100"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u764c\u75c7\u7814\u7a76\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1976385326","https://openalex.org/W1979595420","https://openalex.org/W1983398917","https://openalex.org/W1991070447","https://openalex.org/W2004152446","https://openalex.org/W2038554369","https://openalex.org/W2066868766","https://openalex.org/W2068223140","https://openalex.org/W2075113455","https://openalex.org/W2098719212","https://openalex.org/W2152105216","https://openalex.org/W2318388129","https://openalex.org/W2381092166","https://openalex.org/W2400509040","https://openalex.org/W2412417600","https://openalex.org/W2460146197","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2354115690","https://openalex.org/W2384967756","https://openalex.org/W2362339676","https://openalex.org/W2352750521","https://openalex.org/W2371540663","https://openalex.org/W2387613335","https://openalex.org/W2388043684","https://openalex.org/W2356936008","https://openalex.org/W2392469294","https://openalex.org/W2357819718"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"the":[3,52,61,92,126,132,138],"antitumor":[4],"mechanisms":[5],"of":[6,14,44,65,85,100,128,140],"bifidobacteria":[7,121],"adolescence":[8,122],"in":[9,28,76,91,102,108,117],"vivo.":[10],"Methods:":[11],"The":[12,42,81,96],"content":[13],"extracellular":[15],"signal":[16],"regulated":[17],"proteins":[18],"(ERK)1/2,":[19],"C-Jun":[20],"N-terminal":[21],"kinase":[22],"(JNK),":[23],"p38,":[24],"c-fos":[25,68,134],"and":[26,69,130,135,137],"c-jun":[27,70],"nude":[29,53],"mouse":[30,54],"transplanted":[31,55],"large":[32,103],"bowel":[33,104],"carcinoma":[34,105],"was":[35,46,57,71,87,112],"detected":[36],"by":[37,48],"using":[38],"laser":[39],"confocal":[40],"microscopy.":[41],"expression":[43,133],"NF-\u03baB":[45,101],"determined":[47],"immunohistochemistry.":[49],"Results:":[50],"After":[51],"tumor":[56,77,118],"treated":[58],"with":[59],"bifidobacteria,":[60],"average":[62,82],"fluorescent":[63,83],"strength":[64,84],"ERK1/2,":[66],"JNK,":[67,131],"significantly":[72],"lower":[73,114],"than":[74,115],"that":[75,116],"control":[78],"group":[79,111],"(P<0.01).":[80],"p38":[86],"not":[88],"obvious":[89],"difference":[90],"two":[93],"groups":[94],"(P>0.05).":[95],"positive":[97],"cell":[98],"density":[99],"transplantation":[106],"tumors":[107],"Bifidobacterium":[109],"injection":[110],"markedly":[113,124],"group(P<0.01).":[119],"Conclusion:":[120],"could":[123],"decrease":[125],"activity":[127,139],"ERK1/2":[129],"c-jun,":[136],"NF-\u03baB.":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
