{"id":"https://openalex.org/W2009590767","doi":"https://doi.org/10.1038/ncprheum0674","title":"Adipokines as emerging mediators of immune response and inflammation","display_name":"Adipokines as emerging mediators of immune response and inflammation","publication_year":2007,"publication_date":"2007-11-26","ids":{"openalex":"https://openalex.org/W2009590767","doi":"https://doi.org/10.1038/ncprheum0674","mag":"2009590767","pmid":"https://pubmed.ncbi.nlm.nih.gov/18037931"},"language":"en","primary_location":{"id":"doi:10.1038/ncprheum0674","doi":"https://doi.org/10.1038/ncprheum0674","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncprheum0674","pdf_url":null,"source":{"id":"https://openalex.org/S4210180506","display_name":"Nature Clinical Practice Rheumatology","issn_l":"1745-8382","issn":["1745-8382","1745-8390"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Rheumatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2009590767"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024322272","display_name":"Francisca Lago","orcid":"https://orcid.org/0000-0002-4593-8399","observed_orcids":["https://orcid.org/0000-0002-4593-8399"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisca Lago","raw_affiliation_strings":["Molecular and Cellular Cardiology Research Laboratory, Santiago University Clinical Hospital, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Cardiology Research Laboratory, Santiago University Clinical Hospital, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044168126","display_name":"Carlos Di\u00e9guez","orcid":"https://orcid.org/0000-0002-0919-4337","observed_orcids":["https://orcid.org/0000-0002-0919-4337"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Dieguez","raw_affiliation_strings":["C Dieguez is Director of the Department of Physiology at the University of Santiago de Compostela, Santiago de Compostela, Spain.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C Dieguez is Director of the Department of Physiology at the University of Santiago de Compostela, Santiago de Compostela, Spain.,","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926023","display_name":"Juan Jes\u00fas G\u00f3mez-Reino","orcid":"https://orcid.org/0000-0001-5229-6294","observed_orcids":["https://orcid.org/0000-0001-5229-6294"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan G\u00f3mez-Reino","raw_affiliation_strings":["J G\u00f3mez-Reino is Head of the Rheumatology Division, and O Gualillo is Head of research at the Laboratory of Neuro-endocrine Interactions in Rheumatology and Inflammatory Diseases, both at Santiago University Hospital, Santiago de Compostela, Spain.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J G\u00f3mez-Reino is Head of the Rheumatology Division, and O Gualillo is Head of research at the Laboratory of Neuro-endocrine Interactions in Rheumatology and Inflammatory Diseases, both at Santiago University Hospital, Santiago de Compostela, Spain.,","institution_ids":["https://openalex.org/I4210096311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041596182","display_name":"Oreste Gualillo","orcid":"https://orcid.org/0000-0002-7154-1328","observed_orcids":["https://orcid.org/0000-0002-7154-1328"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Oreste Gualillo","raw_affiliation_strings":["J G\u00f3mez-Reino is Head of the Rheumatology Division, and O Gualillo is Head of research at the Laboratory of Neuro-endocrine Interactions in Rheumatology and Inflammatory Diseases, both at Santiago University Hospital, Santiago de Compostela, Spain.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J G\u00f3mez-Reino is Head of the Rheumatology Division, and O Gualillo is Head of research at the Laboratory of Neuro-endocrine Interactions in Rheumatology and Inflammatory Diseases, both at Santiago University Hospital, Santiago de Compostela, Spain.,","institution_ids":["https://openalex.org/I4210096311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041596182"],"corresponding_institution_ids":["https://openalex.org/I4210096311"],"apc_list":null,"apc_paid":null,"fwci":4.6273,"has_fulltext":false,"cited_by_count":577,"citation_normalized_percentile":{"value":0.97851113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"12","first_page":"716","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":1.0},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":1.0},{"id":"https://openalex.org/keywords/visfatin","display_name":"visfatin","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9330000281333923},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rheumatic-diseases","display_name":"rheumatic diseases","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9882217049598694},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.948063850402832},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8439753651618958},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7188330888748169},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6189371943473816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5783400535583496},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.522944986820221},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5215190052986145},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49092772603034973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4463900625705719},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3960786759853363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3659568727016449},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.17338767647743225}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054409","descriptor_name":"Nicotinamide Phosphoribosyltransferase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ncprheum0674","doi":"https://doi.org/10.1038/ncprheum0674","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncprheum0674","pdf_url":null,"source":{"id":"https://openalex.org/S4210180506","display_name":"Nature Clinical Practice Rheumatology","issn_l":"1745-8382","issn":["1745-8382","1745-8390"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Rheumatology","raw_type":"journal-article"},{"id":"pmid:18037931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18037931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature clinical practice. Rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1493844743","https://openalex.org/W1494472252","https://openalex.org/W1529749053","https://openalex.org/W1539459415","https://openalex.org/W1675830194","https://openalex.org/W1708748675","https://openalex.org/W1932093217","https://openalex.org/W1971452427","https://openalex.org/W1977568667","https://openalex.org/W1982930336","https://openalex.org/W1989758885","https://openalex.org/W1996713062","https://openalex.org/W1997664301","https://openalex.org/W2000639850","https://openalex.org/W2003618903","https://openalex.org/W2012951157","https://openalex.org/W2013354167","https://openalex.org/W2017716013","https://openalex.org/W2022826560","https://openalex.org/W2023128145","https://openalex.org/W2025063713","https://openalex.org/W2044616525","https://openalex.org/W2046878952","https://openalex.org/W2049254268","https://openalex.org/W2052620623","https://openalex.org/W2060660919","https://openalex.org/W2060817939","https://openalex.org/W2060823593","https://openalex.org/W2064038156","https://openalex.org/W2066231422","https://openalex.org/W2068186755","https://openalex.org/W2088475546","https://openalex.org/W2089526417","https://openalex.org/W2104857876","https://openalex.org/W2105506930","https://openalex.org/W2115957483","https://openalex.org/W2124589753","https://openalex.org/W2129316761","https://openalex.org/W2130064617","https://openalex.org/W2134414477","https://openalex.org/W2135110328","https://openalex.org/W2135217300","https://openalex.org/W2136024338","https://openalex.org/W2149849190","https://openalex.org/W2152746369","https://openalex.org/W2154502881","https://openalex.org/W2158079900","https://openalex.org/W2160871497","https://openalex.org/W2165345254","https://openalex.org/W2170273506","https://openalex.org/W2244482505","https://openalex.org/W2346167356"],"related_works":["https://openalex.org/W2157509649","https://openalex.org/W3037901845","https://openalex.org/W2091671277","https://openalex.org/W2007299168","https://openalex.org/W4404719401","https://openalex.org/W2143085509","https://openalex.org/W2103352453","https://openalex.org/W2115633210","https://openalex.org/W2051835216","https://openalex.org/W2130064617"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":56},{"year":2012,"cited_by_count":49}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}