{"id":"https://openalex.org/W2009587067","doi":"https://doi.org/10.7326/0003-4819-104-5-718","title":"New Sensitive lmmunoradiometric Assays for Thyrotropin","display_name":"New Sensitive lmmunoradiometric Assays for Thyrotropin","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2009587067","doi":"https://doi.org/10.7326/0003-4819-104-5-718","mag":"2009587067","pmid":"https://pubmed.ncbi.nlm.nih.gov/3083750"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-104-5-718","doi":"https://doi.org/10.7326/0003-4819-104-5-718","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-104-5-718","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004522280","display_name":"Douglas S. Ross","orcid":"https://orcid.org/0000-0003-2135-461X","observed_orcids":["https://orcid.org/0000-0003-2135-461X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"DOUGLAS S. ROSS","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004522280"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"5","first_page":"718","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tsh-radioimmunoassay","display_name":"TSH radioimmunoassay","score":0.7789999842643738},{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/thyroid-function-tests","display_name":"thyroid function tests","score":0.6899999976158142},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.45899999141693115},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/thyroid-screening","display_name":"thyroid screening","score":0.4480000138282776},{"id":"https://openalex.org/keywords/thyroid-disease-diagnosis","display_name":"thyroid disease diagnosis","score":0.3700000047683716},{"id":"https://openalex.org/keywords/tsh-stimulation-test","display_name":"TSH stimulation test","score":0.5379999876022339},{"id":"https://openalex.org/keywords/tsh-receptor-antibodies","display_name":"TSH receptor antibodies","score":0.36500000953674316},{"id":"https://openalex.org/keywords/tsh-receptor-gene","display_name":"TSH receptor gene","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8499386310577393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8114539384841919},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.7768747806549072},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7627345323562622},{"id":"https://openalex.org/C2778758028","wikidata":"https://www.wikidata.org/wiki/Q19597582","display_name":"Immunoradiometric assay","level":3,"score":0.7604220509529114},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.5804537534713745},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5614709854125977},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.5220296382904053},{"id":"https://openalex.org/C2780214960","wikidata":"https://www.wikidata.org/wiki/Q7199538","display_name":"Pituitary disease","level":3,"score":0.519596517086029},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.4939456582069397},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.47517579793930054},{"id":"https://openalex.org/C4134927","wikidata":"https://www.wikidata.org/wiki/Q7671336","display_name":"TRH stimulation test","level":4,"score":0.41015535593032837}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-104-5-718","doi":"https://doi.org/10.7326/0003-4819-104-5-718","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-104-5-718","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:3083750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3083750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1784747225","https://openalex.org/W1942732270","https://openalex.org/W1978274204","https://openalex.org/W1980520134","https://openalex.org/W2037534038","https://openalex.org/W2057348494","https://openalex.org/W2148436534","https://openalex.org/W4211094247","https://openalex.org/W4299830261","https://openalex.org/W4302364576"],"related_works":["https://openalex.org/W2096948350","https://openalex.org/W7099124524","https://openalex.org/W4302871461","https://openalex.org/W4299830261","https://openalex.org/W2102176370","https://openalex.org/W1855231591","https://openalex.org/W2182313189","https://openalex.org/W2080945946","https://openalex.org/W2072675565","https://openalex.org/W2154797932"],"abstract_inverted_index":{"Editorials1":[0],"May":[1,445,457],"1986New":[2],"Sensitive":[3,195],"lmmunoradiometric":[4],"Assays":[5],"for":[6,14,139,157,175,199,242,264,306,361,387],"ThyrotropinDOUGLAS":[7],"S.":[8,11],"ROSS,":[9,12],"M.D.DOUGLAS":[10],"M.D.Search":[13],"more":[15],"papers":[16],"by":[17,63,290],"this":[18],"authorAuthor,":[19],"Article,":[20,335],"and":[21,74,245,336,355,364,374,398],"Disclosure":[22,337],"Informationhttps://doi.org/10.7326/0003-4819-104-5-718":[23],"SectionsAboutPDF":[24],"ToolsAdd":[25],"to":[26,45,69,115,159,205,427,432],"favoritesDownload":[27],"CitationsTrack":[28],"CitationsPermissions":[29],"ShareFacebookTwitterLinkedInRedditEmail":[30],"ExcerptThyrotropin":[31],"(TSH)":[32,413],"is":[33,322],"the":[34,46,50,55,95,135,207,220,269,331,365,375,433,442],"pituitary":[35,47],"hormone":[36,40,43,237,310,412],"that":[37],"regulates":[38],"thyroid":[39,42,79,140,176,235,246,273,291,308,410],"production;":[41],"feedback":[44,285],"gland":[48],"suppresses":[49],"secretion":[51,289],"of":[52,113,126,151,234,260,272,287,358,367,370,377,405,408,423],"thyrotropin.":[53],"Since":[54],"1970s,":[56],"an":[57],"elevated":[58],"serum":[59,86,90,123,200,307,409],"thyrotropin":[60,87,102,124,158,201,288,360],"concentration":[61],"measured":[62],"radioimmunoassay":[64],"(RIA)":[65],"has":[66],"been":[67],"used":[68,267],"discriminate":[70],"between":[71],"primary":[72,243],"hypothyroidism":[73,244],"euthyroidism.":[75],"Patients":[76],"with":[77,100,392,401],"early":[78],"failure":[80],"(subclinical":[81],"hypothyroidism)":[82],"have":[83,110,122],"elevations":[84],"in":[85,238,418,441],"levels":[88,92],"before":[89],"thyroxine":[91,241],"fall":[93],"below":[94,127],"normal":[96,161],"range.":[97],"In":[98],"patients":[99,239],"hyperthyroidism,":[101],"should":[103],"be":[104,203],"suppressed;":[105],"however,":[106],"conventional":[107],"thyrotropin-RIA":[108],"methods":[109],"detection":[111],"limits":[112],"1":[114,128,444,456],"2":[116],"\u00b5IU/mL,":[117],"whereas":[118],"euthyroid":[119],"persons":[120],"frequently":[121],"concentrations":[125],"\u00b5IU/mL.":[129],"Modified...References1.":[130],"ALLENWATSON":[131],"KD.":[132],"Thyrotropin":[133,373],"as":[134,268,414],"initial":[136,270],"screening":[137],"test":[138,209,222,271,417],"disease":[141],"[Letter].":[142,211,275,311],"Clin":[143,165,212,276],"Chem.":[144,166,213,277],"1984;30:502-3.":[145],"CrossrefMedlineGoogle":[146,168,181,191,227,254,279,298,318],"Scholar2.":[147],"COBBLAMBERTONJACKSON":[148],"WRI.":[149],"Use":[150],"a":[152,261,415,419,428],"rapid,":[153],"sensitive":[154,303],"immunoradiometric":[155,196,304],"assay":[156,197,233,263,305,407],"distinguish":[160],"from":[162],"hyperthyroid":[163],"subjects.":[164],"1984;30:1558-60.":[167],"Scholar3.":[169],"CALDWELLKELLETTGOW":[170],"GHS.":[171],"A":[172,302],"new":[173],"strategy":[174],"function":[177,274],"testing.":[178],"Lancet.":[179,225],"1985;1:1117-9.":[180],"Scholar4.":[182],"RAJATANAVINBRAVERMAN":[183],"RL.":[184],"Euthyroid":[185],"hyperthyroxinemia.":[186],"J":[187,250,295,314],"Endocrinol":[188],"Invest.":[189],"1983;6:493-505.":[190],"Scholar5.":[192],"RODRIGUEZ-ESPINOSAORDONEZ-LLANOSMORA-BRUGUESLOPEZ-CALULLCORTES-RIUS":[193],"JJJCM.":[194],"(IRMA)":[198],"may":[202],"insufficient":[204],"make":[206],"thyrotropin-releasing-factor":[208],"unnecessary":[210],"1985;31:1081-2.":[214],"CrossrefGoogle":[215],"Scholar6.":[216],"KIRKEGAARDBREGENGARD":[217],"CC.":[218],"Is":[219],"TRH":[221],"necessary":[223],"[Letter]?":[224],"1985;1:222.":[226],"Scholar7.":[228],"MARDELLGAMLENWINTON":[229],"RTM.":[230],"High":[231],"sensitivity":[232],"stimulating":[236,309,411],"receiving":[240],"carcinoma.":[247],"Br":[248,312],"Med":[249,313],"[Clin":[251,315],"Res].":[252,316],"1985;290:355-6.":[253],"Scholar8.":[255],"WHITEGERICKE":[256],"GL.":[257],"Diagnostic":[258],"performance":[259],"commercial":[262],"thyrotropin,":[265],"when":[266],"1985;31:1914-6.":[278],"Scholar9.":[280],"LARSEN":[281],"P.":[282],"Thyroid-pituitary":[283],"interaction:":[284],"regulation":[286],"hormones.":[292],"N":[293],"Engl":[294],"Med.":[296],"1982;306:23-32.":[297],"Scholar10.":[299],"SEMPLESLATERREIDGLEN":[300],"CSAA.":[301],"1985;290:69-70.":[317],"Scholar":[319],"This":[320],"content":[321],"PDF":[323,332,459],"only.":[324],"To":[325],"continue":[326],"reading":[327],"please":[328],"click":[329],"on":[330],"icon.":[333],"Author,":[334],"InformationAffiliations:":[338],"PreviousarticleNextarticle":[339],"Advertisement":[340],"FiguresReferencesRelatedDetails":[341],"Metrics":[342],"Cited":[343],"bySERUM":[344],"THYROID-STIMULATING":[345],"HORMONE":[346],"MEASUREMENT":[347],"FOR":[348],"ASSESSMENT":[349],"OF":[350],"THYROID":[351],"FUNCTION":[352],"AND":[353],"DISEASERadioiodination":[354],"quality":[356],"control":[357],"human":[359],"radioimmunoassayThe":[362],"clinician":[363],"thyroidMeasurement":[366],"Thyroid":[368,378,389,395],"FunctionMeasurement":[369],"Parathyroid":[371],"HormoneSerum":[372],"Assessment":[376],"StatusDavid":[379],"A.":[380],"Ehrmann,":[381],"MD,":[382],"David":[383],"H.":[384],"Sarne,":[385],"MDStrategies":[386],"Cost-Effective":[388],"Function":[390],"Testing":[391],"Modern":[393],"MethodsSolitary":[394],"Nodule:":[396],"Diagnosis":[397],"ManagementThyroid":[399],"DysfunctionProblems":[400],"asthma":[402],"following":[403],"treatment":[404],"thyrotoxicosisImmunoradiometric":[406],"first-line":[416],"mixed":[420],"hospital":[421],"populationResponse":[422],"Thyrotropin-Secreting":[424],"Pituitary":[425],"Adenomas":[426],"Long-Acting":[429],"Somatostatin":[430],"AnalogueLetter":[431],"editorEuthyroid":[434],"HyperthyroxinemiaThyroid":[435],"dysfunction":[436],"during":[437],"chronic":[438],"amiodarone":[439],"therapyHyperthyroidism":[440],"Elderly":[443],"1986Volume":[446],"104,":[447],"Issue":[448,454],"5Page:":[449],"718-720KeywordsAttentionHyperthyroidismHypothyroidismPituitary":[450],"glandProlactinRadioimmunoassaysThyroidThyroid":[451],"hormonesThyroid-stimulating":[452],"hormoneThyroxine":[453],"Published:":[455],"1986":[458],"downloadLoading":[460],"...":[461]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}