{"id":"https://openalex.org/W2009586754","doi":"https://doi.org/10.1006/clin.1997.4451","title":"How Subtle Differences in MHC Class II Affect the Severity of Experimental Myasthenia Gravis","display_name":"How Subtle Differences in MHC Class II Affect the Severity of Experimental Myasthenia Gravis","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2009586754","doi":"https://doi.org/10.1006/clin.1997.4451","mag":"2009586754","pmid":"https://pubmed.ncbi.nlm.nih.gov/9434796"},"language":"en","primary_location":{"id":"doi:10.1006/clin.1997.4451","doi":"https://doi.org/10.1006/clin.1997.4451","is_oa":true,"landing_page_url":"https://doi.org/10.1006/clin.1997.4451","pdf_url":null,"source":{"id":"https://openalex.org/S174675264","display_name":"Clinical Immunology and Immunopathology","issn_l":"0090-1229","issn":["0090-1229","1090-2341"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology and Immunopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/clin.1997.4451","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048273104","display_name":"Bingzhi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingzhi Yang","raw_affiliation_strings":["Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287-7519, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287-7519, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053682286","display_name":"Kevin R. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin R. McIntosh","raw_affiliation_strings":["Neuromuscular Unit, Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland, 21287-7519"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromuscular Unit, Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland, 21287-7519","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112223794","display_name":"Daniel B. Drachman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel B. Drachman","raw_affiliation_strings":["Neuromuscular Unit, Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland, 21287-7519"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuromuscular Unit, Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland, 21287-7519","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0436,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.93597827,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"86","issue":"1","first_page":"45","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9769999980926514},{"id":"https://openalex.org/keywords/torpedo-acetylcholine-receptor","display_name":"Torpedo acetylcholine receptor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/acetylcholine-receptor-antibodies","display_name":"acetylcholine receptor antibodies","score":0.7699999809265137},{"id":"https://openalex.org/keywords/t-cell-hybridomas","display_name":"T cell hybridomas","score":0.7630000114440918},{"id":"https://openalex.org/keywords/t-cell-receptor-usage","display_name":"T cell receptor gene usage","score":0.8299999833106995},{"id":"https://openalex.org/keywords/epitope-specificity","display_name":"epitope specificity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6119999885559082},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.6510000228881836},{"id":"https://openalex.org/keywords/congenic-mice","display_name":"congenic mice","score":0.7689999938011169},{"id":"https://openalex.org/keywords/autoimmune-disease-susceptibility","display_name":"autoimmune disease susceptibility","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cdr3-motifs","display_name":"CDR3 motifs","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.7802830934524536},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7102099657058716},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.6890923380851746},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5994191765785217},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5993133783340454},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5992989540100098},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5950973629951477},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.562935471534729},{"id":"https://openalex.org/C123419017","wikidata":"https://www.wikidata.org/wiki/Q7826734","display_name":"Torpedo","level":4,"score":0.5574124455451965},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.5548492670059204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5356115698814392},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5180509090423584},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4932524561882019},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3991785943508148},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3793480694293976},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37919002771377563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16600805521011353},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.140263170003891}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014101","descriptor_name":"Torpedo","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014101","descriptor_name":"Torpedo","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014101","descriptor_name":"Torpedo","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015329","descriptor_name":"Gene Rearrangement, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015329","descriptor_name":"Gene Rearrangement, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015329","descriptor_name":"Gene Rearrangement, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/clin.1997.4451","doi":"https://doi.org/10.1006/clin.1997.4451","is_oa":true,"landing_page_url":"https://doi.org/10.1006/clin.1997.4451","pdf_url":null,"source":{"id":"https://openalex.org/S174675264","display_name":"Clinical Immunology and Immunopathology","issn_l":"0090-1229","issn":["0090-1229","1090-2341"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology and Immunopathology","raw_type":"journal-article"},{"id":"pmid:9434796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9434796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology and immunopathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/clin.1997.4451","doi":"https://doi.org/10.1006/clin.1997.4451","is_oa":true,"landing_page_url":"https://doi.org/10.1006/clin.1997.4451","pdf_url":null,"source":{"id":"https://openalex.org/S174675264","display_name":"Clinical Immunology and Immunopathology","issn_l":"0090-1229","issn":["0090-1229","1090-2341"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology and Immunopathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8082274340","display_name":"TRAINING GRANT IN NEUROMUSCULAR DISEASES AND BIOLOGY","funder_award_id":"5t32ns007368-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8680479485","display_name":null,"funder_award_id":"5T32NS07368","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1487971675","https://openalex.org/W1491680549","https://openalex.org/W1529084123","https://openalex.org/W1575227540","https://openalex.org/W1592779207","https://openalex.org/W1595933309","https://openalex.org/W1602460865","https://openalex.org/W1604301586","https://openalex.org/W1893097780","https://openalex.org/W1909598959","https://openalex.org/W1967925048","https://openalex.org/W1970579419","https://openalex.org/W1976230577","https://openalex.org/W1978050759","https://openalex.org/W1983612134","https://openalex.org/W1983980454","https://openalex.org/W2000560437","https://openalex.org/W2007196541","https://openalex.org/W2010311047","https://openalex.org/W2013036870","https://openalex.org/W2013289639","https://openalex.org/W2018975485","https://openalex.org/W2021106791","https://openalex.org/W2022460169","https://openalex.org/W2024990200","https://openalex.org/W2029443157","https://openalex.org/W2030416301","https://openalex.org/W2031764905","https://openalex.org/W2032883446","https://openalex.org/W2036419686","https://openalex.org/W2042371846","https://openalex.org/W2044824741","https://openalex.org/W2047733004","https://openalex.org/W2048985528","https://openalex.org/W2050082684","https://openalex.org/W2050871949","https://openalex.org/W2051511161","https://openalex.org/W2054232408","https://openalex.org/W2058347590","https://openalex.org/W2058983150","https://openalex.org/W2069216002","https://openalex.org/W2069700888","https://openalex.org/W2080113479","https://openalex.org/W2081915916","https://openalex.org/W2087265319","https://openalex.org/W2090034860","https://openalex.org/W2095252242","https://openalex.org/W2095339034","https://openalex.org/W2106346566","https://openalex.org/W2107805551","https://openalex.org/W2114902952","https://openalex.org/W2115423672","https://openalex.org/W2120586273","https://openalex.org/W2126504125","https://openalex.org/W2134812217","https://openalex.org/W2138270253","https://openalex.org/W2140985128","https://openalex.org/W2145021410","https://openalex.org/W2159361718","https://openalex.org/W2172466148","https://openalex.org/W2331818774","https://openalex.org/W2599782464","https://openalex.org/W3135645624","https://openalex.org/W4248406156","https://openalex.org/W4294216491"],"related_works":["https://openalex.org/W2071623222","https://openalex.org/W2079180409","https://openalex.org/W2126504125","https://openalex.org/W1511406668","https://openalex.org/W2046231107","https://openalex.org/W2065392423","https://openalex.org/W2006174441","https://openalex.org/W201744056","https://openalex.org/W2107805551","https://openalex.org/W1982922358"],"abstract_inverted_index":{"Myasthenia":[0],"gravis":[1,33],"is":[2],"an":[3,12],"autoimmune":[4],"disorder":[5],"characterized":[6,88],"by":[7,36],"muscle":[8],"weakness,":[9],"due":[10],"to":[11,52,104,141,149,158,162],"antibody-mediated":[13],"deficit":[14],"of":[15,30,45,67,79,151,156,183,196],"acetylcholine":[16],"receptors":[17],"(AChRs)":[18],"at":[19],"neuromuscular":[20],"junctions.":[21],"We":[22,75,177],"analyzed":[23],"the":[24,28,100,174,180,190],"factors":[25],"that":[26,179],"determine":[27],"severity":[29],"experimental":[31],"myasthenia":[32],"(EAMG)":[34],"induced":[35],"immunization":[37],"with":[38,198,204],"Torpedo":[39,159],"AChR,":[40],"in":[41,64,71,167,189,208],"two":[42],"congenic":[43],"strains":[44],"mice--B6":[46],"mice,":[47,56,169],"which":[48,57],"are":[49,58],"highly":[50],"susceptible":[51],"EAMG;":[53],"and":[54,61,87,92,111,119,123,132,160,170,187,201,212,217],"bm12":[55,126],"relatively":[59],"resistant,":[60],"differ":[62],"only":[63],"a":[65,105,209],"change":[66],"three":[68],"amino":[69],"acids":[70],"MHC":[72,184],"Class":[73],"II.":[74],"prepared":[76],"large":[77],"numbers":[78],"AChR-specific":[80],"T":[81,93,199,202],"cell":[82,94],"hybridomas":[83,102,127,150],"from":[84],"each":[85],"strain":[86],"their":[89,112,152],"epitope":[90,130],"specificities":[91,131],"receptor":[95],"(TCR)":[96],"gene":[97],"usage:":[98],"Half":[99],"B6":[101,168,191],"responded":[103],"single":[106],"AChR":[107,143,164,214],"peptide":[108],"(alpha":[109],"146-162),":[110],"TCR":[113,136,188],"genes":[114],"encoded":[115],"restricted":[116,135],"V":[117,120],"alpha":[118],"beta":[121],"chains":[122],"CDR3":[124],"motifs.":[125],"had":[128],"different":[129],"different,":[133],"less":[134],"genes.":[137],"APCs":[138,197],"were":[139,165,171],"able":[140],"present":[142],"or":[144],"AChR-derived":[145],"peptides":[146],"virtually":[147],"exclusively":[148],"own":[153],"strain.":[154],"Levels":[155],"antibodies":[157],"autoantibodies":[161],"mouse":[163],"higher":[166],"biased":[172],"toward":[173],"IgG2b":[175],"isotype.":[176],"conclude":[178],"\"better":[181],"fit\"":[182],"II,":[185],"peptide,":[186],"mice":[192],"enhanced":[193],"cognate":[194],"interactions":[195],"cells,":[200,206],"cells":[203],"B":[205],"resulting":[207],"more":[210,219],"abundant":[211],"pathogenic":[213],"antibody":[215],"response,":[216],"thus":[218],"severe":[220],"EAMG.":[221]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}