{"id":"https://openalex.org/W2009540971","doi":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","title":"Fibronectin Receptor Defects in NOD Mouse Leucocytes: Possible Consequences for Type 1 Diabetes","display_name":"Fibronectin Receptor Defects in NOD Mouse Leucocytes: Possible Consequences for Type 1 Diabetes","publication_year":2004,"publication_date":"2004-07-05","ids":{"openalex":"https://openalex.org/W2009540971","doi":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","mag":"2009540971","pmid":"https://pubmed.ncbi.nlm.nih.gov/15238071"},"language":"en","primary_location":{"id":"doi:10.1111/j.0300-9475.2004.01465.x","doi":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023448596","display_name":"Sacha Brigitte Geutskens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"S. B. Geutskens","raw_affiliation_strings":["H\u00f4pital Necker CNRS UMR-8147, Universit\u00e9 Paris V, 161 rue de Sevres, 75743 Paris Cedex 15, France","Department of Immunology, Erasmus MC, Rotterdam, the Netherlands; and","H\u00f4pital Necker CNRS UMR\u20108147, Universit\u00e9 Paris V, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Necker CNRS UMR-8147, Universit\u00e9 Paris V, 161 rue de Sevres, 75743 Paris Cedex 15, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Department of Immunology, Erasmus MC, Rotterdam, the Netherlands; and","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"H\u00f4pital Necker CNRS UMR\u20108147, Universit\u00e9 Paris V, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013870471","display_name":"Daniella Ar\u00eaas Mendes\u2010da\u2010Cruz","orcid":"https://orcid.org/0000-0003-3697-1506","observed_orcids":["https://orcid.org/0000-0003-3697-1506"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D. A. Mendes\u2010da\u2010Cruz","raw_affiliation_strings":["Laboratory on Thymus Research, Department of Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory on Thymus Research, Department of Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049430192","display_name":"Mireille Dardenne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M. Dardenne","raw_affiliation_strings":["Ho\u0302pital Necker CNRS UMR-8147, Universite\u0301 Paris V, Paris, France;","H\u00f4pital Necker CNRS UMR\u20108147, Universit\u00e9 Paris V, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ho\u0302pital Necker CNRS UMR-8147, Universite\u0301 Paris V, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"H\u00f4pital Necker CNRS UMR\u20108147, Universit\u00e9 Paris V, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063166816","display_name":"Wilson Savino","orcid":"https://orcid.org/0000-0002-5802-3120","observed_orcids":["https://orcid.org/0000-0002-5802-3120"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR","FR"],"is_corresponding":false,"raw_author_name":"W. Savino","raw_affiliation_strings":["Ho\u0302pital Necker CNRS UMR-8147, Universite\u0301 Paris V, Paris, France;","Laboratory on Thymus Research, Department of Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","H\u00f4pital Necker CNRS UMR-8147, Universit\u00e9 Paris V, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ho\u0302pital Necker CNRS UMR-8147, Universite\u0301 Paris V, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Laboratory on Thymus Research, Department of Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"raw_affiliation_string":"H\u00f4pital Necker CNRS UMR-8147, Universit\u00e9 Paris V, Paris, France;","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5049430192"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I1294671590","https://openalex.org/I4387156284"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0343,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.03448276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"60","issue":"1-2","first_page":"30","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha5beta1","display_name":"alpha5beta1 integrin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vla-4","display_name":"VLA-4","score":0.8230000138282776},{"id":"https://openalex.org/keywords/integrin-alpha4beta1","display_name":"alpha4beta1 integrin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.8140000104904175},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.7210000157356262},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.6779999732971191},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7409999966621399},{"id":"https://openalex.org/keywords/macrophage-maturation","display_name":"macrophage maturation","score":0.871999979019165},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lymphocyte-trafficking","display_name":"lymphocyte migration","score":0.5}],"concepts":[{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.7997456789016724},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7699266672134399},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.6844133734703064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6214430928230286},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.58669513463974},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5401960611343384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4876950681209564},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4772993326187134},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45720726251602173},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42887169122695923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26198703050613403},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21728628873825073},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.17591753602027893},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1445154845714569},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06083521246910095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017469","descriptor_name":"Receptors, Fibronectin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D039041","descriptor_name":"Integrin alpha4beta1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.0300-9475.2004.01465.x","doi":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0300-9475.2004.01465.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15238071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15238071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/22029ed2-5631-4bd1-9994-4d111653aa70","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/22029ed2-5631-4bd1-9994-4d111653aa70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geutskens, SB, Mendes-da-Cruz, DA, Dardenne, M & Savino, W 2004, 'Fibronectin receptor defects in NOD mouse leucocytes: possible consequences for type 1 diabetes', Scandinavian Journal of Immunology, vol. 60, pp. 30-38. https://doi.org/10.1111/j.0300-9475.2004.01465.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/22029ed2-5631-4bd1-9994-4d111653aa70","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/22029ed2-5631-4bd1-9994-4d111653aa70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scandinavian Journal of Immunology, 60, 30 - 38. Wiley-Blackwell Publishing Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1480207260","https://openalex.org/W1499727701","https://openalex.org/W1514064771","https://openalex.org/W1866073711","https://openalex.org/W1905978178","https://openalex.org/W1939326986","https://openalex.org/W1965827039","https://openalex.org/W1969778924","https://openalex.org/W1971019443","https://openalex.org/W1991260416","https://openalex.org/W1992769276","https://openalex.org/W1994340136","https://openalex.org/W1995446704","https://openalex.org/W1995879433","https://openalex.org/W2007608304","https://openalex.org/W2017256134","https://openalex.org/W2022453973","https://openalex.org/W2024804515","https://openalex.org/W2027552805","https://openalex.org/W2038801248","https://openalex.org/W2045758494","https://openalex.org/W2052083000","https://openalex.org/W2052250748","https://openalex.org/W2057024358","https://openalex.org/W2057898581","https://openalex.org/W2059704957","https://openalex.org/W2066826893","https://openalex.org/W2070181989","https://openalex.org/W2072647934","https://openalex.org/W2073421421","https://openalex.org/W2078678936","https://openalex.org/W2084322883","https://openalex.org/W2084969813","https://openalex.org/W2089645383","https://openalex.org/W2089964497","https://openalex.org/W2095204375","https://openalex.org/W2095806067","https://openalex.org/W2096520512","https://openalex.org/W2101295479","https://openalex.org/W2102067914","https://openalex.org/W2104167652","https://openalex.org/W2105807629","https://openalex.org/W2115677315","https://openalex.org/W2125177388","https://openalex.org/W2125939378","https://openalex.org/W2130737345","https://openalex.org/W2132435075","https://openalex.org/W2133966414","https://openalex.org/W2135947561","https://openalex.org/W2146259054","https://openalex.org/W2148528048","https://openalex.org/W2169306631","https://openalex.org/W2410457253","https://openalex.org/W2411139466","https://openalex.org/W2419538297","https://openalex.org/W2441265528","https://openalex.org/W2467592953","https://openalex.org/W4313333849"],"related_works":["https://openalex.org/W2039288100","https://openalex.org/W2069042428","https://openalex.org/W2051413679","https://openalex.org/W2038801248","https://openalex.org/W69742986","https://openalex.org/W2463040301","https://openalex.org/W2070636175","https://openalex.org/W2138869419","https://openalex.org/W3108483398","https://openalex.org/W2062077368"],"abstract_inverted_index":{"Integrins":[0],"of":[1,30,39,42,53,71,96,103,132,176,183,191,220],"the":[2,26,40,50,63,84,93,115,129,139,189,199,216,221],"very":[3],"late":[4],"antigen":[5],"(VLA)":[6],"family":[7],"mediate":[8],"leucocyte":[9],"traffic":[10],"to":[11,138,198,233],"lymphoid":[12],"organs":[13],"under":[14],"physiological":[15],"conditions":[16],"and":[17,37,59,151],"in":[18,62,92,99,120,160,165,215,225],"chronic":[19],"inflammatory":[20],"situations":[21],"such":[22],"as":[23,171,173],"autoimmunity.":[24,43],"Accordingly,":[25],"current":[27],"thinking":[28],"is":[29],"a":[31,68,90,100,158],"positive":[32],"correlation":[33],"between":[34],"VLA":[35],"expression":[36,52,95,150,164],"capability":[38],"generation":[41],"Herein":[44],"we":[45,156],"discuss":[46],"recent":[47],"findings":[48],"on":[49,188],"defective":[51],"integrin-type":[54],"fibronectin":[55,162,206],"receptors":[56],"alpha4beta1":[57,161],"(VLA-4)":[58],"alpha5beta1":[60,125,140,148],"(VLA-5)":[61],"non-obese":[64],"diabetic":[65],"(NOD)":[66],"mouse,":[67],"murine":[69],"model":[70],"autoimmune":[72,222,245],"insulin-dependent":[73],"diabetes":[74],"mellitus.":[75],"As":[76],"compared":[77],"with":[78],"normal":[79],"animals,":[80],"NOD":[81,121,166,177,202,226],"thymocytes":[82,110],"(including":[83],"CD4+CD25+":[85],"regulatory":[86],"T":[87,143],"cells)":[88],"exhibit":[89,146],"decrease":[91],"membrane":[94,149],"alpha5beta1,":[97],"resulting":[98],"functional":[101],"impairment":[102],"fibronectin-mediated":[104],"interactions,":[105],"including":[106],"cell":[107,208],"migration.":[108,154],"Interestingly,":[109],"that":[111,128,201],"are":[112,123],"trapped":[113],"within":[114],"giant":[116],"perivascular":[117],"spaces":[118],"seen":[119,224],"thymus":[122],"consistently":[124],"negative,":[126],"suggesting":[127],"progressive":[130],"arrest":[131],"mature":[133],"cells":[134,144],"can":[135,240],"be":[136,213,231,241],"related":[137],"defect.":[141],"Peripheral":[142],"also":[145],"decreased":[147],"impaired":[152,181],"fibronectin-driven":[153],"Additionally,":[155],"observed":[157],"defect":[159],"receptor":[163],"macrophages.":[167],"Peritoneal,":[168],"bone":[169],"marrow-derived-precursor,":[170],"well":[172],"thymic":[174],"macrophages":[175],"mice":[178],"showed":[179],"an":[180],"upregulation":[182],"alpha4-integrin":[184],"chain":[185],"expression,":[186],"dependent":[187],"level":[190],"macrophage":[192],"maturation.":[193],"Overall":[194],"these":[195],"data":[196],"lead":[197],"notion":[200],"leucocytes":[203],"bear":[204],"distinct":[205],"receptor-mediated":[207],"migration":[209],"defects,":[210],"which":[211],"may":[212],"involved":[214],"pathogenesis":[217],"and/or":[218],"pathophysiology":[219],"events":[223],"mice.":[227],"Further":[228],"studies":[229],"will":[230],"helpful":[232],"define":[234],"whether":[235],"or":[236],"not":[237],"this":[238],"concept":[239],"applied":[242],"for":[243],"other":[244],"diseases.":[246]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}