{"id":"https://openalex.org/W2009533670","doi":"https://doi.org/10.1167/iovs.06-0908","title":"Thyroxine Ameliorates Oxidative Stress by Inducing Lipid Compositional Changes in Human Lens Epithelial Cells","display_name":"Thyroxine Ameliorates Oxidative Stress by Inducing Lipid Compositional Changes in Human Lens Epithelial Cells","publication_year":2007,"publication_date":"2007-07-25","ids":{"openalex":"https://openalex.org/W2009533670","doi":"https://doi.org/10.1167/iovs.06-0908","mag":"2009533670","pmid":"https://pubmed.ncbi.nlm.nih.gov/17652741"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.06-0908","doi":"https://doi.org/10.1167/iovs.06-0908","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.06-0908","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025898981","display_name":"Li Juan Huang","orcid":"https://orcid.org/0000-0001-7389-1105","observed_orcids":["https://orcid.org/0000-0001-7389-1105","https://orcid.org/0009-0004-0861-9876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Huang","raw_affiliation_strings":["From the Departments of Ophthalmology and Visual Science,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and Visual Science,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109848112","display_name":"Marta Cecilia Yappert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta C. Yappert","raw_affiliation_strings":["Chemistry, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113641605","display_name":"James J. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Miller","raw_affiliation_strings":["Pathology, University of Louisville, Louisville, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University of Louisville, Louisville, Kentucky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031315736","display_name":"Douglas Borchman","orcid":"https://orcid.org/0000-0003-4241-591X","observed_orcids":["https://orcid.org/0000-0003-4241-591X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Borchman","raw_affiliation_strings":["From the Departments of Ophthalmology and Visual Science,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and Visual Science,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.847,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.71307506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"8","first_page":"3698","last_page":"3698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.12330000102519989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lipid-oxidation","display_name":"lipid oxidation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lipid-saturation","display_name":"lipid saturation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cardiolipin","display_name":"cardiolipin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cataract-prevention","display_name":"cataract prevention","score":0.7699999809265137},{"id":"https://openalex.org/keywords/membrane-lipid-composition","display_name":"membrane lipid composition","score":0.5400000214576721},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.38100001215934753},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7070000171661377},{"id":"https://openalex.org/keywords/mitochondrial-antioxidants","display_name":"mitochondrial antioxidants","score":0.3889999985694885},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cataract-risk","display_name":"cataract risk","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.7595496773719788},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7463594675064087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7242857813835144},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.5157158970832825},{"id":"https://openalex.org/C2994476132","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid oxidation","level":3,"score":0.5003845691680908},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4289548695087433},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4256553649902344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3795187473297119},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.26818400621414185},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24201416969299316},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.23289012908935547}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1167/iovs.06-0908","doi":"https://doi.org/10.1167/iovs.06-0908","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.06-0908","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:17652741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17652741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W8128757","https://openalex.org/W77534462","https://openalex.org/W97815548","https://openalex.org/W120409319","https://openalex.org/W1496818982","https://openalex.org/W1501564271","https://openalex.org/W1542672737","https://openalex.org/W1786885738","https://openalex.org/W1837111152","https://openalex.org/W1972150645","https://openalex.org/W1972666591","https://openalex.org/W1981057989","https://openalex.org/W1981116356","https://openalex.org/W1981183002","https://openalex.org/W1986170848","https://openalex.org/W1995031501","https://openalex.org/W1996158201","https://openalex.org/W2000113270","https://openalex.org/W2000181169","https://openalex.org/W2004693594","https://openalex.org/W2008837386","https://openalex.org/W2019164724","https://openalex.org/W2022504743","https://openalex.org/W2024174176","https://openalex.org/W2032786707","https://openalex.org/W2033415893","https://openalex.org/W2039961720","https://openalex.org/W2042225342","https://openalex.org/W2042328931","https://openalex.org/W2043009133","https://openalex.org/W2044368656","https://openalex.org/W2059598932","https://openalex.org/W2062975913","https://openalex.org/W2069921430","https://openalex.org/W2074947501","https://openalex.org/W2080396964","https://openalex.org/W2081120259","https://openalex.org/W2086883421","https://openalex.org/W2087050453","https://openalex.org/W2088826552","https://openalex.org/W2091062367","https://openalex.org/W2118935778","https://openalex.org/W2169957088","https://openalex.org/W2178503775","https://openalex.org/W2190250344","https://openalex.org/W2317399755","https://openalex.org/W2470035947"],"related_works":["https://openalex.org/W2170758738","https://openalex.org/W2190250344","https://openalex.org/W178644314","https://openalex.org/W7100279293","https://openalex.org/W2417051780","https://openalex.org/W1981183002","https://openalex.org/W1973807957","https://openalex.org/W1989991128","https://openalex.org/W4210584853","https://openalex.org/W2112181382"],"abstract_inverted_index":{"PURPOSE:":[0],"Lipid":[1],"saturation":[2,31,324,345],"and":[3,32,41,66,97,164,291,316,319,330,343],"sphingolipids":[4,194,318],"make":[5],"model":[6],"membranes":[7,312],"less":[8],"susceptible":[9],"to":[10,24,44,118,258,286,328,340],"oxidation.":[11,54,125],"A":[12,113,248],"human":[13],"lens":[14,348],"epithelial":[15],"cell":[16,289],"line,":[17],"HLE":[18,59],"B-3,":[19],"was":[20,62,69,87,105,116,273],"treated":[21,63],"with":[22,64,107,184,200,243,253],"thyroxine":[23,153,254],"determine":[25],"whether":[26,46],"this":[27],"treatment":[28,48,231,255],"increases":[29],"lipid":[30,53,124,206,236,299,344],"membrane":[33,199],"sphingolipids,":[34],"as":[35],"it":[36],"does":[37],"in":[38,75,132,178,188,196,212,217,222,226,245,251,261,281,295,302,346],"other":[39],"tissues,":[40],"if":[42],"so,":[43],"see":[45],"the":[47,50,120,136,146,155,165,174,179,189,193,233,267,296,309,347,351],"ameliorates":[49],"affects":[51],"of":[52,58,123,130,152,181,192,205,235,298,323,337,353],"METHODS:":[55],"One":[56],"group":[57,68],"B-3":[60],"cells":[61,138,214,224,332],"thyroxine,":[65],"another":[67],"not.":[70],"Cells":[71],"were":[72,139,145,167,173,208],"then":[73],"grown":[74,225],"a":[76,108,133,150,185,197,218,227,259,292,338],"normoxic":[77,228],"(20%":[78],"O(2)),":[79,83],"or":[80],"hyperoxic":[81,134,219],"(80%":[82],"atmosphere.":[84,229],"Phospholipid":[85],"composition":[86],"determined":[88,106],"by":[89,239,266,276],"matrix-assisted":[90],"laser":[91],"desorption":[92],"ionization":[93],"time-of-flight":[94],"mass":[95],"spectrometry":[96],"(31)P":[98],"nuclear":[99],"magnetic":[100],"resonance":[101],"spectroscopy.":[102],"Cell":[103],"viability":[104,290],"trypan":[109],"blue":[110],"dye":[111],"assay.":[112],"chromogenic":[114],"reagent":[115],"used":[117],"measure":[119],"secondary":[121],"products":[122,238,301],"RESULTS:":[126],"After":[127],"6":[128],"days":[129],"growth":[131,216],"atmosphere,":[135],"thyroxine-treated":[137,303],"20":[140],"times":[141,169,210],"more":[142,170,314,317,326],"viable":[143],"than":[144,172,221],"untreated":[147,213,223,246],"cells.":[148,247,304],"As":[149],"result":[151],"treatment,":[154],"phosphatidylcholine":[156],"(PC)-to-sphingolipid":[157],"molar":[158],"ratio":[159],"decreased":[160],"significantly":[161],"(by":[162],"52%),":[163],"PCs":[166,182],"eight":[168],"unsaturated":[171],"sphingomyelins.":[175],"The":[176,269,306],"decrease":[177,187,260,294],"amount":[180,234,297],"coupled":[183],"33%":[186],"average":[190],"unsaturation":[191],"resulted":[195],"phospholipid":[198],"fewer":[201],"double":[202],"bonds.":[203],"Products":[204],"oxidation":[207,237,300,329],"three":[209],"higher":[211,321],"after":[215],"atmosphere":[220],"Thyroxine":[230],"reduced":[232],"approximately":[240],"60%":[241],"compared":[242],"that":[244,311],"100%":[249],"increase":[250,341],"cardiolipin":[252,315],"may":[256,349],"contribute":[257],"reactive":[262],"oxygen":[263],"species":[264],"generated":[265],"mitochondria.":[268],"total":[270],"antioxidant":[271,282],"power":[272],"not":[274],"affected":[275],"thyroxine.":[277],"Therefore,":[278],"thyroxine-induced":[279],"fluctuations":[280],"levels":[283,322],"are":[284,325],"unlikely":[285],"influence":[287],"increased":[288],"concomitant":[293],"CONCLUSIONS:":[305],"results":[307],"support":[308],"idea":[310],"containing":[313],"having":[320],"resistant":[327],"protect":[331],"from":[333],"oxidative":[334],"stress.":[335],"Development":[336],"therapy":[339],"sphingomyelins":[342],"delay":[350],"onset":[352],"cataract.":[354]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}