{"id":"https://openalex.org/W2009519981","doi":"https://doi.org/10.1001/archneur.66.2.280","title":"Genetic Polymorphism at Codon 129 of the Prion Protein Gene Is Not Associated With Multiple Sclerosis","display_name":"Genetic Polymorphism at Codon 129 of the Prion Protein Gene Is Not Associated With Multiple Sclerosis","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2009519981","doi":"https://doi.org/10.1001/archneur.66.2.280","mag":"2009519981","pmid":"https://pubmed.ncbi.nlm.nih.gov/19204171"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.66.2.280","doi":"https://doi.org/10.1001/archneur.66.2.280","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.66.2.280","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035339589","display_name":"Olaf St\u00fcve","orcid":"https://orcid.org/0000-0002-0469-6872","observed_orcids":["https://orcid.org/0000-0002-0469-6872"]},"institutions":[{"id":"https://openalex.org/I4210104138","display_name":"VA North Texas Health Care System","ror":"https://ror.org/01nzxq896","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104138","https://openalex.org/I4210144023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olaf St\u00fcve","raw_affiliation_strings":["Veterans Affairs North Texas Health Care System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs North Texas Health Care System","institution_ids":["https://openalex.org/I4210104138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089353861","display_name":"Carsten Korth","orcid":"https://orcid.org/0000-0003-1503-1822","observed_orcids":["https://orcid.org/0000-0003-1503-1822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten Korth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071250715","display_name":"Pablo Gabatto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pablo Gabatto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109208907","display_name":"Elizabeth M. Cameron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth M. Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074276627","display_name":"Todd N. Eagar","orcid":"https://orcid.org/0000-0002-9738-544X","observed_orcids":["https://orcid.org/0000-0002-9738-544X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd N. Eagar","raw_affiliation_strings":["Institute for Academic Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Academic Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109079767","display_name":"Nancy L. Monson","orcid":"https://orcid.org/0000-0002-7175-7700","observed_orcids":["https://orcid.org/0000-0002-7175-7700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy L. Monson","raw_affiliation_strings":["Neurology & Neurotherapeutics - NE Multiple Sclerosis Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology & Neurotherapeutics - NE Multiple Sclerosis Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058205908","display_name":"Elliot M. Frohman","orcid":"https://orcid.org/0000-0002-0674-8680","observed_orcids":["https://orcid.org/0000-0002-0674-8680","https://orcid.org/0000-0001-7774-3951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elliot M. Frohman","raw_affiliation_strings":["Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021514185","display_name":"Michael K. Racke","orcid":"https://orcid.org/0000-0002-1231-4694","observed_orcids":["https://orcid.org/0000-0002-1231-4694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael K. Racke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004855604","display_name":"Cyrus P. Zabetian","orcid":"https://orcid.org/0000-0002-7739-4306","observed_orcids":["https://orcid.org/0000-0002-7739-4306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cyrus P. Zabetian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088568312","display_name":"Jorge R. Oksenberg","orcid":"https://orcid.org/0000-0002-3613-9544","observed_orcids":["https://orcid.org/0000-0002-3613-9544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge R. Oksenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8912,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75353653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"66","issue":"2","first_page":"280","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prnp","display_name":"prion protein gene","score":0.8989999890327454},{"id":"https://openalex.org/keywords/codon-129-polymorphism","display_name":"codon 129 polymorphism","score":0.9290000200271606},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.8740000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6969457864761353},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6478722095489502},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6295128464698792},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5189597010612488},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.4939149022102356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49369439482688904},{"id":"https://openalex.org/C176990463","wikidata":"https://www.wikidata.org/wiki/Q1854186","display_name":"Start codon","level":4,"score":0.44509658217430115},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.31348156929016113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21894961595535278},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12239539623260498},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.11324435472488403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.074729323387146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040582","descriptor_name":"Inheritance Patterns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.66.2.280","doi":"https://doi.org/10.1001/archneur.66.2.280","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.66.2.280","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:19204171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19204171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1543868019","https://openalex.org/W1914444904","https://openalex.org/W1992114179","https://openalex.org/W1998661139","https://openalex.org/W2048364891","https://openalex.org/W2054904323","https://openalex.org/W2072038834","https://openalex.org/W2073194793","https://openalex.org/W2084863623","https://openalex.org/W2102304594","https://openalex.org/W2103000719","https://openalex.org/W2116256646","https://openalex.org/W2139344244"],"related_works":["https://openalex.org/W2168042963","https://openalex.org/W4250848895","https://openalex.org/W1998661139","https://openalex.org/W1997525821","https://openalex.org/W181083288","https://openalex.org/W2068799247","https://openalex.org/W1985434642","https://openalex.org/W2527778290","https://openalex.org/W1000348305","https://openalex.org/W2466210098"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}