{"id":"https://openalex.org/W2009487182","doi":"https://doi.org/10.1126/science.1167418","title":"Antagonistic Actions of Msx1 and Osr2 Pattern Mammalian Teeth into a Single Row","display_name":"Antagonistic Actions of Msx1 and Osr2 Pattern Mammalian Teeth into a Single Row","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2009487182","doi":"https://doi.org/10.1126/science.1167418","mag":"2009487182","pmid":"https://pubmed.ncbi.nlm.nih.gov/19251632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2650836"},"language":"en","primary_location":{"id":"doi:10.1126/science.1167418","doi":"https://doi.org/10.1126/science.1167418","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1167418","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2650836","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022249164","display_name":"Zunyi Zhang","orcid":"https://orcid.org/0000-0002-0370-1596","observed_orcids":["https://orcid.org/0000-0002-0370-1596"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zunyi Zhang","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019190546","display_name":"Yu Lan","orcid":"https://orcid.org/0000-0001-5611-3600","observed_orcids":["https://orcid.org/0000-0001-5611-3600"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu Lan","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473366","display_name":"Yang Chai","orcid":"https://orcid.org/0000-0003-2477-7247","observed_orcids":["https://orcid.org/0000-0003-2477-7247"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Chai","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050198479","display_name":"Rulang Jiang","orcid":"https://orcid.org/0000-0001-7842-4696","observed_orcids":["https://orcid.org/0000-0001-7842-4696"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rulang Jiang","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019190546","https://openalex.org/A5022249164","https://openalex.org/A5050198479"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":5.0944,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.96496117,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"323","issue":"5918","first_page":"1232","last_page":"1234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/msx1","display_name":"MSX1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/osr2","display_name":"Osr2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.7570000290870667},{"id":"https://openalex.org/keywords/supernumerary-teeth","display_name":"supernumerary teeth","score":0.9480000138282776},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5809999704360962},{"id":"https://openalex.org/keywords/tooth-development","display_name":"tooth development","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8163861036300659},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.6728495955467224},{"id":"https://openalex.org/C188126409","wikidata":"https://www.wikidata.org/wiki/Q641973","display_name":"Dentition","level":2,"score":0.5945144891738892},{"id":"https://openalex.org/C2781316418","wikidata":"https://www.wikidata.org/wiki/Q14903397","display_name":"Bone morphogenetic protein 4","level":4,"score":0.5572218298912048},{"id":"https://openalex.org/C2776094402","wikidata":"https://www.wikidata.org/wiki/Q17927891","display_name":"FGF8","level":4,"score":0.5460137128829956},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.5095048546791077},{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.48749780654907227},{"id":"https://openalex.org/C2780610479","wikidata":"https://www.wikidata.org/wiki/Q7644068","display_name":"Supernumerary","level":2,"score":0.4185379147529602},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3917478919029236},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3216645121574402},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.30335259437561035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14253968000411987},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.13743838667869568},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.06729322671890259},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003817","descriptor_name":"Dentition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008963","descriptor_name":"Molar","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009805","descriptor_name":"Odontogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014083","descriptor_name":"Tooth Germ","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014083","descriptor_name":"Tooth Germ","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014096","descriptor_name":"Tooth, Supernumerary","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051957","descriptor_name":"MSX1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051957","descriptor_name":"MSX1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.1167418","doi":"https://doi.org/10.1126/science.1167418","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1167418","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:19251632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19251632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2650836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2650836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2650836","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2650836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1934008728","display_name":"Molecular Genetic Analysis of Craniofacial Development","funder_award_id":"R01DE013681","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6115924259","display_name":"TRAINING PROGRAM IN ORAL SCIENCE","funder_award_id":"T32DE007202","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1963641861","https://openalex.org/W1985792161","https://openalex.org/W1988765975","https://openalex.org/W1991382572","https://openalex.org/W1992635050","https://openalex.org/W2008362502","https://openalex.org/W2020250544","https://openalex.org/W2030667392","https://openalex.org/W2030718399","https://openalex.org/W2034717801","https://openalex.org/W2047178578","https://openalex.org/W2051277013","https://openalex.org/W2051843832","https://openalex.org/W2057972383","https://openalex.org/W2058760260","https://openalex.org/W2096538364","https://openalex.org/W2105747363","https://openalex.org/W2136981091","https://openalex.org/W2137494284","https://openalex.org/W2138448751","https://openalex.org/W2140146453","https://openalex.org/W2157137464","https://openalex.org/W2160217803","https://openalex.org/W2162726549","https://openalex.org/W2166646853"],"related_works":["https://openalex.org/W2007419913","https://openalex.org/W2158699064","https://openalex.org/W2527806632","https://openalex.org/W2108415652","https://openalex.org/W2074443277","https://openalex.org/W2074101994","https://openalex.org/W2051539021","https://openalex.org/W2137494284","https://openalex.org/W2011774897","https://openalex.org/W4210817997"],"abstract_inverted_index":{"Mammals":[0],"have":[1,8],"single-rowed":[2],"dentitions,":[3],"whereas":[4],"many":[5],"nonmammalian":[6],"vertebrates":[7],"teeth":[9,45],"in":[10,27,60,77,86],"multiple":[11],"rows.":[12],"Neither":[13],"the":[14,37,54,78,101],"molecular":[15],"mechanism":[16,120],"regulating":[17],"iterative":[18],"tooth":[19,25,80,109],"initiation":[20],"nor":[21],"that":[22,34,100,112],"restricting":[23],"mammalian":[24],"development":[26],"one":[28],"row":[29],"is":[30],"known.":[31],"We":[32],"found":[33],"mice":[35,88],"lacking":[36],"transcription":[38],"factor":[39],"odd-skipped":[40],"related-2":[41],"(Osr2)":[42],"develop":[43],"supernumerary":[44],"lingual":[46],"to":[47],"their":[48],"molars":[49],"because":[50],"of":[51,53,67,83,94,115],"expansion":[52],"odontogenic":[55,75,84],"field.":[56],"Osr2":[57],"was":[58],"expressed":[59],"a":[61,91,119],"lingual-to-buccal":[62],"gradient":[63],"and":[64,111],"restricted":[65],"expression":[66],"bone":[68],"morphogenetic":[69],"protein":[70],"4":[71],"(Bmp4),":[72],"an":[73],"essential":[74],"signal,":[76],"developing":[79],"mesenchyme.":[81],"Expansion":[82],"field":[85],"Osr2-deficient":[87],"required":[89],"Msx1,":[90],"feedback":[92],"activator":[93],"Bmp4":[95],"expression.":[96],"These":[97],"findings":[98],"suggest":[99],"Bmp4-Msx1":[102],"pathway":[103,117],"propagates":[104],"mesenchymal":[105],"activation":[106],"for":[107,121],"sequential":[108],"induction":[110],"spatial":[113],"modulation":[114],"this":[116],"provides":[118],"patterning":[122],"vertebrate":[123],"dentition.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}