{"id":"https://openalex.org/W2009463608","doi":"https://doi.org/10.1101/gad.1413606","title":"Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1","display_name":"Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1","publication_year":2006,"publication_date":"2006-05-15","ids":{"openalex":"https://openalex.org/W2009463608","doi":"https://doi.org/10.1101/gad.1413606","mag":"2009463608","pmid":"https://pubmed.ncbi.nlm.nih.gov/16702404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1472905"},"language":"en","primary_location":{"id":"doi:10.1101/gad.1413606","doi":"https://doi.org/10.1101/gad.1413606","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1413606","pdf_url":"http://genesdev.cshlp.org/content/20/10/1308.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/20/10/1308.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036233446","display_name":"Chun\u2010Li Zhang","orcid":"https://orcid.org/0000-0002-2639-4605","observed_orcids":["https://orcid.org/0000-0002-2639-4605"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Li Zhang","raw_affiliation_strings":["Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA","Gene Expression Laboratory","Howard Hughes Medical Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Gene Expression Laboratory","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute,","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111940818","display_name":"Yuhua Zou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuhua Zou","raw_affiliation_strings":["Gene Expression Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056064034","display_name":"Ruth T. Yu","orcid":"https://orcid.org/0000-0002-9527-9627","observed_orcids":["https://orcid.org/0000-0002-9527-9627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth T. Yu","raw_affiliation_strings":["Gene Expression Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087519016","display_name":"Ronald M. Evans","orcid":"https://orcid.org/0000-0002-9986-5965","observed_orcids":["https://orcid.org/0000-0002-9986-5965"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Evans","raw_affiliation_strings":["Gene Expression Laboratory","Howard Hughes Medical Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute,","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"10","first_page":"1308","last_page":"1320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlx","display_name":"TLX","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nr2e1","display_name":"NR2E1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/orphan-nuclear-receptor","display_name":"orphan nuclear receptor","score":0.8140000104904175},{"id":"https://openalex.org/keywords/retinal-dystrophy","display_name":"retinal dystrophy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/retinal-progenitor-cells","display_name":"retinal progenitor cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s-cones","display_name":"S-cones","score":0.7400000095367432},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.5410000085830688},{"id":"https://openalex.org/keywords/eye-development","display_name":"eye development","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.881575882434845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6392321586608887},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.6316850185394287},{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.5295078754425049},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5270100831985474},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45445042848587036},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35301315784454346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3212946653366089},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2521386742591858},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15925925970077515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017949","descriptor_name":"Retinal Cone Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017949","descriptor_name":"Retinal Cone Photoreceptor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1101/gad.1413606","doi":"https://doi.org/10.1101/gad.1413606","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1413606","pdf_url":"http://genesdev.cshlp.org/content/20/10/1308.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmid:16702404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16702404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gad.1413606","doi":"https://doi.org/10.1101/gad.1413606","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1413606","pdf_url":"http://genesdev.cshlp.org/content/20/10/1308.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1428261219","display_name":"Spatial Regulation of Developmental Gene Expression","funder_award_id":"R01HD027183","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2317500230","display_name":null,"funder_award_id":"HD-27183","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320311350","display_name":"Life Sciences Research Foundation","ror":"https://ror.org/0195dxj21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009463608.pdf","grobid_xml":"https://content.openalex.org/works/W2009463608.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W59248935","https://openalex.org/W1492821183","https://openalex.org/W1525882285","https://openalex.org/W1533487943","https://openalex.org/W1556074533","https://openalex.org/W1599277155","https://openalex.org/W1676958442","https://openalex.org/W1793681151","https://openalex.org/W1817917437","https://openalex.org/W1830258850","https://openalex.org/W1967153587","https://openalex.org/W1968703962","https://openalex.org/W1972452899","https://openalex.org/W1974208182","https://openalex.org/W1979440192","https://openalex.org/W1979762984","https://openalex.org/W1980451446","https://openalex.org/W1985243799","https://openalex.org/W1987780959","https://openalex.org/W1995685873","https://openalex.org/W1995754186","https://openalex.org/W1996451053","https://openalex.org/W2006874274","https://openalex.org/W2012481532","https://openalex.org/W2013851169","https://openalex.org/W2014462207","https://openalex.org/W2015426350","https://openalex.org/W2019071873","https://openalex.org/W2022732247","https://openalex.org/W2022768206","https://openalex.org/W2028190732","https://openalex.org/W2035819383","https://openalex.org/W2037390777","https://openalex.org/W2037602867","https://openalex.org/W2044335290","https://openalex.org/W2060692611","https://openalex.org/W2061491996","https://openalex.org/W2062901218","https://openalex.org/W2069470894","https://openalex.org/W2072751609","https://openalex.org/W2077066627","https://openalex.org/W2079437966","https://openalex.org/W2081113123","https://openalex.org/W2081994535","https://openalex.org/W2090922624","https://openalex.org/W2101019828","https://openalex.org/W2101116356","https://openalex.org/W2104682649","https://openalex.org/W2111062014","https://openalex.org/W2111105486","https://openalex.org/W2131060923","https://openalex.org/W2146977555","https://openalex.org/W2147630434","https://openalex.org/W2148050076","https://openalex.org/W2151726169","https://openalex.org/W2161071918","https://openalex.org/W2169906167","https://openalex.org/W2170909470","https://openalex.org/W2186780489","https://openalex.org/W2316848840","https://openalex.org/W2345333028","https://openalex.org/W4249853575","https://openalex.org/W6638775186","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W7095270063","https://openalex.org/W2111105486","https://openalex.org/W2147630434","https://openalex.org/W2272798697","https://openalex.org/W2992715144","https://openalex.org/W634661729","https://openalex.org/W1990260908","https://openalex.org/W3047591463","https://openalex.org/W3217253941","https://openalex.org/W588072704"],"abstract_inverted_index":{"During":[0],"mammalian":[1],"embryogenesis,":[2],"precise":[3],"coordination":[4],"of":[5,21,63,92,95,113,145],"progenitor":[6,51,75],"cell":[7,52,55,96],"proliferation":[8,53,165],"and":[9,17,42,54,65,83,89,110,115,139,166,173],"differentiation":[10,76,167],"is":[11,131,141],"essential":[12,142],"for":[13,143],"proper":[14],"organ":[15],"size":[16],"function.":[18],"The":[19],"involvement":[20],"TLX":[22,48,71,123],"(NR2E1),":[23],"an":[24,93,157],"orphan":[25,158],"nuclear":[26,159],"receptor,":[27],"has":[28],"been":[29],"implicated":[30],"in":[31,107,133],"ocular":[32],"development,":[33],"as":[34],"Tlx-/-":[35,101],"mice":[36,102],"exhibit":[37],"visual":[38],"impairment.":[39],"Using":[40],"genetic":[41],"biochemical":[43],"approaches,":[44],"we":[45],"show":[46],"that":[47,130,140],"modulates":[49],"retinal":[50,120,171],"cycle":[56],"re-entry":[57],"by":[58,78,155],"directly":[59],"regulating":[60],"the":[61,74,80,90],"expression":[62,91],"Pten":[64],"its":[66],"target":[67],"cyclin":[68],"D1.":[69],"Additionally,":[70],"finely":[72],"tunes":[73],"program":[77],"modulating":[79],"phospholipase":[81],"C":[82],"mitogen-activated":[84],"protein":[85],"kinase":[86],"(MAPK)":[87],"pathways":[88],"array":[94],"type-specific":[97],"transcriptional":[98],"regulators.":[99],"Consequently,":[100],"have":[103],"a":[104,128,152],"dramatic":[105],"reduction":[106],"retina":[108],"thickness":[109],"enhanced":[111],"generation":[112],"S-cones,":[114],"develop":[116],"severe":[117],"early":[118],"onset":[119],"dystrophy.":[121],"Furthermore,":[122],"interacts":[124],"with":[125],"atrophin1":[126],"(Atn1),":[127],"corepressor":[129],"involved":[132],"human":[134],"neurodegenerative":[135],"dentatorubral-pallidoluysian":[136],"atrophy":[137],"(DRPLA)":[138],"development":[144],"multiple":[146],"tissues.":[147],"Together,":[148],"these":[149],"results":[150],"reveal":[151],"molecular":[153],"strategy":[154],"which":[156],"receptor":[160],"can":[161],"precisely":[162],"orchestrate":[163],"tissue-specific":[164],"programs":[168],"to":[169],"prevent":[170],"malformation":[172],"degeneration.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
