{"id":"https://openalex.org/W2009449023","doi":"https://doi.org/10.4161/epi.26017","title":"DNA methylation analysis of murine hematopoietic side population cells during aging","display_name":"DNA methylation analysis of murine hematopoietic side population cells during aging","publication_year":2013,"publication_date":"2013-08-28","ids":{"openalex":"https://openalex.org/W2009449023","doi":"https://doi.org/10.4161/epi.26017","mag":"2009449023","pmid":"https://pubmed.ncbi.nlm.nih.gov/23949429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891692"},"language":"en","primary_location":{"id":"doi:10.4161/epi.26017","doi":"https://doi.org/10.4161/epi.26017","is_oa":true,"landing_page_url":"https://doi.org/10.4161/epi.26017","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/epi.26017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065426000","display_name":"Oluwatosin Taiwo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oluwatosin Taiwo","raw_affiliation_strings":["Medical Genomics; UCL Cancer Institute; University College London; London, UK; UCL Institute of Healthy Ageing; University College London; London, UK","London, UK","Medical Genomics","UCL Cancer Institute","UCL Institute of Healthy Ageing","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genomics; UCL Cancer Institute; University College London; London, UK; UCL Institute of Healthy Ageing; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"Medical Genomics","institution_ids":[]},{"raw_affiliation_string":"UCL Cancer Institute","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Institute of Healthy Ageing","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025813081","display_name":"Gareth A. Wilson","orcid":"https://orcid.org/0000-0002-5703-9710","observed_orcids":["https://orcid.org/0000-0002-5703-9710"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth A Wilson","raw_affiliation_strings":["Medical Genomics; UCL Cancer Institute; University College London; London, UK","London, UK","Medical Genomics","UCL Cancer Institute","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genomics; UCL Cancer Institute; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"Medical Genomics","institution_ids":[]},{"raw_affiliation_string":"UCL Cancer Institute","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056921400","display_name":"Warren Emmett","orcid":"https://orcid.org/0009-0002-4739-1515","observed_orcids":["https://orcid.org/0009-0002-4739-1515","https://orcid.org/0000-0003-2721-3164"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Warren Emmett","raw_affiliation_strings":["UCL Genetics Institute; University College London; London, UK","London, UK","UCL Genetics Institute","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Genetics Institute; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"UCL Genetics Institute","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109701447","display_name":"Tiffany J. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tiffany Morris","raw_affiliation_strings":["Medical Genomics; UCL Cancer Institute; University College London; London, UK","London, UK","Medical Genomics","UCL Cancer Institute","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genomics; UCL Cancer Institute; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"Medical Genomics","institution_ids":[]},{"raw_affiliation_string":"UCL Cancer Institute","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016016794","display_name":"Dominique A. Bonnet","orcid":"https://orcid.org/0000-0002-4735-5226","observed_orcids":["https://orcid.org/0000-0002-4735-5226"]},"institutions":[{"id":"https://openalex.org/I1292966370","display_name":"The Honourable Society of Lincoln's Inn","ror":"https://ror.org/010npae67","country_code":"GB","type":"other","lineage":["https://openalex.org/I1292966370"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dominique Bonnet","raw_affiliation_strings":["Cancer Research UK; London Research Institute; Lincoln's Inn Fields; London, UK","Cancer Research UK","Lincoln's Inn Fields","London Research Institute","London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK; London Research Institute; Lincoln's Inn Fields; London, UK","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Cancer Research UK","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Lincoln's Inn Fields","institution_ids":["https://openalex.org/I1292966370"]},{"raw_affiliation_string":"London Research Institute","institution_ids":[]},{"raw_affiliation_string":"London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028878272","display_name":"Eugene F. Schuster","orcid":"https://orcid.org/0000-0001-5076-2810","observed_orcids":["https://orcid.org/0000-0001-5076-2810"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eugene Schuster","raw_affiliation_strings":["UCL Institute of Healthy Ageing; University College London; London, UK","London, UK","UCL Institute of Healthy Ageing","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Healthy Ageing; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"UCL Institute of Healthy Ageing","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026401780","display_name":"Tomas Adejumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tomas Adejumo","raw_affiliation_strings":["Scientific Support Services; Flow Facility; University College London; London, UK","Flow Facility","London, UK","Scientific Support Services","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Support Services; Flow Facility; University College London; London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Flow Facility","institution_ids":[]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"Scientific Support Services","institution_ids":[]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017588786","display_name":"Stephan Beck","orcid":"https://orcid.org/0000-0001-5290-2151","observed_orcids":["https://orcid.org/0000-0001-5290-2151"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephan Beck","raw_affiliation_strings":["Medical Genomics; UCL Cancer Institute; University College London; London, UK; These senior authors contributed equally to this work","London, UK","Medical Genomics","UCL Cancer Institute","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genomics; UCL Cancer Institute; University College London; London, UK; These senior authors contributed equally to this work","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"Medical Genomics","institution_ids":[]},{"raw_affiliation_string":"UCL Cancer Institute","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":null,"display_name":"Daniel J Pearce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel J Pearce","raw_affiliation_strings":["UCL Institute of Healthy Ageing; University College London; London, UK; These senior authors contributed equally to this work","London, UK","UCL Institute of Healthy Ageing","University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Healthy Ageing; University College London; London, UK; These senior authors contributed equally to this work","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"London, UK","institution_ids":[]},{"raw_affiliation_string":"UCL Institute of Healthy Ageing","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017588786"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":1.5396,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.81876526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"1114","last_page":"1122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6610000133514404},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"differentially methylated regions","score":0.9229999780654907},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.7419999837875366},{"id":"https://openalex.org/keywords/5-aza-deoxycytidine","display_name":"5-aza-deoxycytidine","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9332744479179382},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6987031698226929},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5801395177841187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49028709530830383},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.48743584752082825},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4629787802696228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46214520931243896},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44849586486816406},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3750007748603821},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3348625600337982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28840172290802},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25298988819122314},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13017165660858154},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D028044","descriptor_name":"Phosphate-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.4161/epi.26017","doi":"https://doi.org/10.4161/epi.26017","is_oa":true,"landing_page_url":"https://doi.org/10.4161/epi.26017","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2887781","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3891692","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3891692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Text"},{"id":"pmid:23949429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23949429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1406698","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1406698/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epigenetics , 8 (10) pp. 1114-1122. (2013)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.4161/epi.26017","doi":"https://doi.org/10.4161/epi.26017","is_oa":true,"landing_page_url":"https://doi.org/10.4161/epi.26017","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6164732379","display_name":"Genetics of the MHC and LRC.","funder_award_id":"084071","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1973035870","https://openalex.org/W1979674827","https://openalex.org/W1985801522","https://openalex.org/W1986635328","https://openalex.org/W2002287699","https://openalex.org/W2012860082","https://openalex.org/W2030106108","https://openalex.org/W2030181113","https://openalex.org/W2033766516","https://openalex.org/W2036055444","https://openalex.org/W2039165739","https://openalex.org/W2041191257","https://openalex.org/W2053856108","https://openalex.org/W2056598800","https://openalex.org/W2065437731","https://openalex.org/W2077248943","https://openalex.org/W2092387193","https://openalex.org/W2097162553","https://openalex.org/W2101259235","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2109715726","https://openalex.org/W2114970231","https://openalex.org/W2118508190","https://openalex.org/W2120060263","https://openalex.org/W2131187320","https://openalex.org/W2131263031","https://openalex.org/W2132083557","https://openalex.org/W2132854782","https://openalex.org/W2134555277","https://openalex.org/W2134924448","https://openalex.org/W2137956382","https://openalex.org/W2139333804","https://openalex.org/W2142053177","https://openalex.org/W2146812443","https://openalex.org/W2152239989","https://openalex.org/W2156165856","https://openalex.org/W2158804744","https://openalex.org/W2165101781","https://openalex.org/W2165626882","https://openalex.org/W2167319166"],"related_works":["https://openalex.org/W7009160279","https://openalex.org/W2142053177","https://openalex.org/W763618948","https://openalex.org/W2979488834","https://openalex.org/W2558222861","https://openalex.org/W4387965693","https://openalex.org/W7213512696","https://openalex.org/W2040612005","https://openalex.org/W2923240246","https://openalex.org/W2590328976"],"abstract_inverted_index":{"Stem":[0],"cells":[1,11,56],"have":[2],"been":[3],"found":[4],"in":[5,41,96,125,165,179,227,235],"most":[6],"tissues/organs.":[7],"These":[8],"somatic":[9,42],"stem":[10,43,55,207],"produce":[12],"replacements":[13],"for":[14,60,147],"lost":[15],"and":[16,19,69,72,139,184,193,219],"damaged":[17],"cells,":[18],"it":[20],"is":[21],"not":[22],"completely":[23],"understood":[24],"how":[25],"this":[26,172],"regenerative":[27],"capacity":[28],"becomes":[29],"diminished":[30],"during":[31,205],"aging.":[32],"To":[33,170],"study":[34],"the":[35,119,129,148,180],"possible":[36],"involvement":[37],"of":[38,87,90,182],"epigenetic":[39],"changes":[40,122,224],"cell":[44,208],"aging,":[45,209],"we":[46,82,175],"used":[47],"murine":[48],"hematopoiesis":[49],"as":[50],"a":[51,84,186],"model":[52],"system.":[53],"Hematopoietic":[54],"(HSCs)":[57],"were":[58,112,141],"enriched":[59],"via":[61,232],"Hoechst":[62],"exclusion":[63],"activity":[64],"(SP-HSC)":[65],"from":[66],"young,":[67],"medium-aged":[68],"old":[70],"mice":[71],"subjected":[73],"to":[74,153],"comprehensive,":[75],"global":[76,85],"methylome":[77],"(MeDIP-seq)":[78],"analysis.":[79],"With":[80],"age,":[81,218],"observed":[83],"loss":[86],"DNA":[88,199,236],"methylation":[89,97,192,200],"approximately":[91],"5%,":[92],"but":[93],"an":[94,163],"increase":[95,164],"at":[98],"some":[99],"CpG":[100],"islands.":[101],"Just":[102],"over":[103],"100":[104],"significant":[105],"(FDR<0.2)":[106],"aging-specific":[107],"differentially":[108],"methylated":[109,216],"regions":[110],"(aDMRs)":[111],"identified,":[113],"which":[114],"are":[115,202,214],"surprisingly":[116],"few":[117],"considering":[118],"profound":[120],"age-based":[121,233],"that":[123,198,211,221],"occur":[124],"HSC":[126],"biology.":[127],"Interestingly,":[128],"polycomb":[130],"repressive":[131],"complex":[132],"-2":[133],"(PCRC2)":[134],"target":[135],"genes":[136],"Kiss1r,":[137],"Nav2":[138],"Hsf4":[140],"hypermethylated":[142],"with":[143,157,162,168,217,225],"age.":[144,158,169],"The":[145],"promoter":[146,191],"Sdpr":[149,190],"gene":[150,166,194],"was":[151],"determined":[152],"be":[154,230],"progressively":[155],"hypomethylated":[156],"This":[159],"occurred":[160],"concurrently":[161],"expression":[167,223],"explore":[171],"relationship":[173],"further,":[174],"cultured":[176],"isolated":[177],"SP-HSC":[178],"presence":[181],"5-aza-deoxycytdine":[183],"demonstrated":[185],"negative":[187],"correlation":[188],"between":[189],"expression.":[195],"We":[196],"report":[197],"patterns":[201],"well":[203],"preserved":[204],"hematopoietic":[206],"confirm":[210],"PCRC2":[212],"targets":[213],"increasingly":[215],"suggest":[220],"SDPR":[222],"age":[226],"HSCs":[228],"may":[229],"regulated":[231],"alterations":[234],"methylation.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
