{"id":"https://openalex.org/W2009408779","doi":"https://doi.org/10.1006/taap.1995.1002","title":"Single Versus Multiple Dose Administration of All-trans-retinoic Acid during Organogenesis: Differential Metabolism and Transplacental Kinetics in Rat and Rabbit","display_name":"Single Versus Multiple Dose Administration of All-trans-retinoic Acid during Organogenesis: Differential Metabolism and Transplacental Kinetics in Rat and Rabbit","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2009408779","doi":"https://doi.org/10.1006/taap.1995.1002","mag":"2009408779","pmid":"https://pubmed.ncbi.nlm.nih.gov/7839374"},"language":"en","primary_location":{"id":"doi:10.1006/taap.1995.1002","doi":"https://doi.org/10.1006/taap.1995.1002","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.1995.1002","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064349824","display_name":"Michael D. Collins","orcid":"https://orcid.org/0000-0001-5117-7760","observed_orcids":["https://orcid.org/0000-0001-5117-7760"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["CH","DE","US"],"is_corresponding":false,"raw_author_name":"M.D. Collins","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, FRG","Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, FRG","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012282437","display_name":"Georg Tzimas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["CH","DE","US"],"is_corresponding":false,"raw_author_name":"G. Tzimas","raw_affiliation_strings":["Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867","https://openalex.org/I75951250"]},{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065574480","display_name":"Heinrich B\u00fcrgin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["CH","DE","US"],"is_corresponding":false,"raw_author_name":"H. Burgin","raw_affiliation_strings":["Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867","https://openalex.org/I75951250"]},{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018435034","display_name":"Hans Hummler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["CH","DE","US"],"is_corresponding":false,"raw_author_name":"H. Hummler","raw_affiliation_strings":["Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867","https://openalex.org/I75951250"]},{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109943894","display_name":"Heinz Nau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["CH","DE","US"],"is_corresponding":false,"raw_author_name":"H. Nau","raw_affiliation_strings":["Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany; Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA; Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867","https://openalex.org/I75951250"]},{"raw_affiliation_string":"Free Univ Berlin, Inst Toxicol & Embryopharmacol, D 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Childrens Hosp Res Fdn, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229, USA and F Hoffmann La Roche & Co Ltd, CH 4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":4.0957,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93379747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"130","issue":"1","first_page":"9","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/toxicokinetics","display_name":"toxicokinetics","score":0.7089999914169312},{"id":"https://openalex.org/keywords/transplacental-transfer","display_name":"transplacental transfer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.7369999885559082},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/retinoic-acid-binding-protein","display_name":"retinoic acid-binding protein","score":0.8629999756813049},{"id":"https://openalex.org/keywords/maternal-plasma-concentration","display_name":"maternal plasma concentration","score":0.6100000143051147},{"id":"https://openalex.org/keywords/embryo","display_name":"embryo","score":0.6389999985694885},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6309999823570251},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.7937557697296143},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.661146879196167},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6469070911407471},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5918107628822327},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5559558272361755},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.5422995090484619},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.5254812836647034},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4183613061904907},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4162176847457886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41362518072128296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3938630223274231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32796987891197205},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2412858009338379},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12610864639282227},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.12462747097015381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/taap.1995.1002","doi":"https://doi.org/10.1006/taap.1995.1002","is_oa":false,"landing_page_url":"https://doi.org/10.1006/taap.1995.1002","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:7839374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7839374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2147406728","https://openalex.org/W2075055416","https://openalex.org/W1990011740","https://openalex.org/W2013693833","https://openalex.org/W7015485825","https://openalex.org/W1967440349","https://openalex.org/W2035665692","https://openalex.org/W2031859484","https://openalex.org/W2024401375","https://openalex.org/W2002810221"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
