{"id":"https://openalex.org/W2009405449","doi":"https://doi.org/10.1021/bi00198a019","title":"Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide","display_name":"Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide","publication_year":1994,"publication_date":"1994-10-16","ids":{"openalex":"https://openalex.org/W2009405449","doi":"https://doi.org/10.1021/bi00198a019","mag":"2009405449","pmid":"https://pubmed.ncbi.nlm.nih.gov/7520750"},"language":"en","primary_location":{"id":"doi:10.1021/bi00198a019","doi":"https://doi.org/10.1021/bi00198a019","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00198a019","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076709279","display_name":"Eiji Majima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Majima","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022218841","display_name":"Yasuo Shinohara","orcid":"https://orcid.org/0000-0002-5331-3508","observed_orcids":["https://orcid.org/0000-0002-5331-3508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuo Shinohara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032840591","display_name":"Nana Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nana Yamaguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113567599","display_name":"Yeong-Man Hong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeong-Man Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103195998","display_name":"Hiroshi Terada","orcid":"https://orcid.org/0000-0001-9901-5998","observed_orcids":["https://orcid.org/0000-0001-9901-5998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Terada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3917,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.80859795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"32","first_page":"9530","last_page":"9536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-adp-atp-carrier","display_name":"mitochondrial ADP/ATP carrier","score":0.9679999947547913},{"id":"https://openalex.org/keywords/adenine-nucleotide-transport","display_name":"adenine nucleotide transport","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.8069999814033508},{"id":"https://openalex.org/keywords/carboxyatractyloside","display_name":"carboxyatractyloside","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bongkrekic-acid","display_name":"bongkrekic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/adp-inhibition","display_name":"ADP inhibition","score":0.796999990940094},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8169999718666077},{"id":"https://openalex.org/keywords/submitochondrial-particles","display_name":"submitochondrial particles","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bovine-heart","display_name":"bovine heart","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780105360","wikidata":"https://www.wikidata.org/wiki/Q6743002","display_name":"Maleimide","level":2,"score":0.963072657585144},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.8276399374008179},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.7076202034950256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7017977237701416},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5039512515068054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49005234241485596},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.44159233570098877},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2881283760070801},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.19687911868095398},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1866057813167572}],"mesh":[{"descriptor_ui":"D000226","descriptor_name":"Mitochondrial ADP, ATP Translocases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001278","descriptor_name":"Atractyloside","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001278","descriptor_name":"Atractyloside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001865","descriptor_name":"Bongkrekic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013367","descriptor_name":"Submitochondrial Particles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013367","descriptor_name":"Submitochondrial Particles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00198a019","doi":"https://doi.org/10.1021/bi00198a019","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00198a019","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7520750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7520750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W937204623","https://openalex.org/W1507060386","https://openalex.org/W1528093928","https://openalex.org/W1551826863","https://openalex.org/W1573998173","https://openalex.org/W1746465795","https://openalex.org/W1972240339","https://openalex.org/W1976167616","https://openalex.org/W1978678285","https://openalex.org/W1986491100","https://openalex.org/W1997599110","https://openalex.org/W2016232024","https://openalex.org/W2021165430","https://openalex.org/W2028763981","https://openalex.org/W2030363176","https://openalex.org/W2034259280","https://openalex.org/W2039857920","https://openalex.org/W2053033635","https://openalex.org/W2057088972","https://openalex.org/W2063253626","https://openalex.org/W2072006920","https://openalex.org/W2090627083","https://openalex.org/W2100837269","https://openalex.org/W2118466889","https://openalex.org/W2126394471","https://openalex.org/W2313380666","https://openalex.org/W2399359243"],"related_works":["https://openalex.org/W1507060386","https://openalex.org/W2092717502","https://openalex.org/W2059757894","https://openalex.org/W2047612546","https://openalex.org/W1974300529","https://openalex.org/W1970529716","https://openalex.org/W2049176419","https://openalex.org/W828334557","https://openalex.org/W2055145001","https://openalex.org/W2034259280"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,24,31,54,64,92,104,112,120,173,187],"various":[3],"compounds":[4],"such":[5],"as":[6,74],"the":[7,12,22,28,37,45,50,52,90,102,110,118,127,137,141,147,154,164,170,174,192],"transport":[8,13,190],"substrate":[9],"ADP":[10,88,181],"and":[11,17,60,62,66,95,108,180],"inhibitors":[14],"carboxyatractyloside":[15],"(CATR)":[16],"bongkrekic":[18],"acid":[19],"(BKA)":[20],"on":[21,153,163],"labeling":[23,53,103,111,119,148],"cysteine":[25,47],"residues":[26,48],"in":[27,49,136,195,199],"ADP/ATP":[29,193],"carrier":[30,175,194],"bovine":[32],"heart":[33],"submitochondrial":[34],"particles":[35],"by":[36,56,97,106,149,177],"SH":[38],"reagent":[39],"eosin-5-maleimide":[40],"(EMA)":[41],"were":[42],"studied.":[43],"Of":[44],"four":[46],"carrier,":[51],"Cys159":[55,105,135],"EMA":[57,150],"progressed":[58],"predominantly":[59],"rapidly,":[61],"those":[63],"Cys56":[65],"Cys256":[67,96],"moderately,":[68],"but":[69,114,157],"Cys128":[70],"was":[71],"not":[72,116],"labeled,":[73],"we":[75],"reported":[76],"previously":[77],"[Majima,":[78],"E.,":[79],"et":[80],"al.":[81],"(1993)":[82],"J.":[83],"Biol.":[84],"Chem.":[85],"268,":[86],"22181-22187].":[87],"inhibited":[89,101,146],"labelings":[91],"Cys56,":[93,121],"Cys159,":[94],"EMA.":[98],"BKA":[99],"markedly":[100],"EMA,":[107],"also":[109],"Cys256,":[113],"did":[115],"affect":[117],"suggesting":[122],"that":[123],"it":[124],"binds":[125],"from":[126],"matrix":[128,142,165],"side":[129],"to":[130,134],"a":[131,185],"region":[132],"close":[133],"second":[138],"loop":[139],"facing":[140],"space.":[143],"CATR":[144],"completely":[145],"when":[151,161],"added":[152,162],"cytosolic":[155],"side,":[156],"had":[158],"no":[159],"effect":[160],"side.":[166],"From":[167],"these":[168],"results,":[169],"conformational":[171],"changes":[172],"induced":[176],"CATR,":[178],"BKA,":[179],"are":[182],"discussed.":[183],"Furthermore,":[184],"mechanism":[186],"adenine":[188],"nucleotide":[189],"through":[191],"association":[196],"with":[197],"change":[198],"its":[200],"conformation":[201],"is":[202],"proposed.":[203]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
