{"id":"https://openalex.org/W2009399532","doi":"https://doi.org/10.1172/jci114068","title":"Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.","display_name":"Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2009399532","doi":"https://doi.org/10.1172/jci114068","mag":"2009399532","pmid":"https://pubmed.ncbi.nlm.nih.gov/2708529","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/303877"},"language":"en","primary_location":{"id":"doi:10.1172/jci114068","doi":"https://doi.org/10.1172/jci114068","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114068","pdf_url":"http://www.jci.org/articles/view/114068/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114068/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113772278","display_name":"Charles S. Lieber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C S Lieber","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, Alcohol Research and Treatment Center, Bronx, NY 10468"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, Alcohol Research and Treatment Center, Bronx, NY 10468","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000884349","display_name":"Enrique Baraona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"E Baraona","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I98285908","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017586770","display_name":"Rolando Efra\u00edn Hern\u00e1ndez-Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-5010-775X","observed_orcids":["https://orcid.org/0000-0002-5010-775X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"R Hern\u00e1ndez-Mu\u00f1oz","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I98285908","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Kubota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"S Kubota","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I98285908","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003135996","display_name":"Nobuhiro Sato","orcid":"https://orcid.org/0000-0001-8436-4247","observed_orcids":["https://orcid.org/0000-0001-8436-4247"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Sato","raw_affiliation_strings":["Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100658517","display_name":"Seiji Kawano","orcid":"https://orcid.org/0000-0002-7807-5147","observed_orcids":["https://orcid.org/0000-0002-7807-5147"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Kawano","raw_affiliation_strings":["Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Matsumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Matsumura","raw_affiliation_strings":["Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol Research and Treatment Center, V. A. Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"last","author":{"id":null,"display_name":"N Inatomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"N Inatomi","raw_affiliation_strings":["Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bronx Veterans Administration Medical Center, Mount Sinai School ofMedicine, New York 10468; and tOsaka University Medical School, Osaka, Japan","institution_ids":["https://openalex.org/I98285908","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":7.3021,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.97561602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"83","issue":"5","first_page":"1682","last_page":"1690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-induced-hepatotoxicity","display_name":"ethanol-induced hepatotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/alcoholic-liver-injury","display_name":"alcoholic liver injury","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hepatic-oxygen-consumption","display_name":"hepatic oxygen consumption","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mitochondrial-injury","display_name":"mitochondrial injury","score":0.8140000104904175},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.9139999747276306},{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/splanchnic-circulation","display_name":"splanchnic circulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.703000009059906},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.790835440158844},{"id":"https://openalex.org/C30153976","wikidata":"https://www.wikidata.org/wiki/Q6011565","display_name":"Ethanol metabolism","level":3,"score":0.6569413542747498},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6265571713447571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5635428428649902},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.5616099834442139},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5565758943557739},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.5301663875579834},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5206750631332397},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5116727352142334},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.3977757394313812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38617056608200073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.367500364780426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31431132555007935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3114904761314392}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014781","descriptor_name":"Viscera","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014781","descriptor_name":"Viscera","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014781","descriptor_name":"Viscera","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci114068","doi":"https://doi.org/10.1172/jci114068","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114068","pdf_url":"http://www.jci.org/articles/view/114068/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:2708529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2708529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:303877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC303877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.947.6801","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.947.6801","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/114000/114068/JCI89114068.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci114068","doi":"https://doi.org/10.1172/jci114068","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114068","pdf_url":"http://www.jci.org/articles/view/114068/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7749132134","display_name":"METABOLISM OF ALCOHOL AND ASSOCIATED PATHOLOGIC EFFECTS","funder_award_id":"P50AA003508","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009399532.pdf","grobid_xml":"https://content.openalex.org/works/W2009399532.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W92165150","https://openalex.org/W98090258","https://openalex.org/W194426825","https://openalex.org/W227904711","https://openalex.org/W1695702879","https://openalex.org/W1841137333","https://openalex.org/W1959956691","https://openalex.org/W1964864334","https://openalex.org/W1968510701","https://openalex.org/W1979874273","https://openalex.org/W1983800917","https://openalex.org/W1990273008","https://openalex.org/W1993672704","https://openalex.org/W1994228113","https://openalex.org/W2005002704","https://openalex.org/W2012499983","https://openalex.org/W2026512247","https://openalex.org/W2026635928","https://openalex.org/W2027747645","https://openalex.org/W2028538562","https://openalex.org/W2030954141","https://openalex.org/W2034156633","https://openalex.org/W2043173659","https://openalex.org/W2046048009","https://openalex.org/W2063682294","https://openalex.org/W2074492396","https://openalex.org/W2078033902","https://openalex.org/W2080276147","https://openalex.org/W2081144914","https://openalex.org/W2081565428","https://openalex.org/W2088300144","https://openalex.org/W2094500174","https://openalex.org/W2097808704","https://openalex.org/W2099653432","https://openalex.org/W2103501392","https://openalex.org/W2108789866","https://openalex.org/W2129792326","https://openalex.org/W2133429006","https://openalex.org/W2134316260","https://openalex.org/W2150445215","https://openalex.org/W2157286372","https://openalex.org/W2167393318","https://openalex.org/W2172839876","https://openalex.org/W2194605486","https://openalex.org/W2313912803","https://openalex.org/W2339552494","https://openalex.org/W2395207984","https://openalex.org/W2403761205","https://openalex.org/W2410885163","https://openalex.org/W2412572072","https://openalex.org/W2425514342","https://openalex.org/W2469588576","https://openalex.org/W2584127608","https://openalex.org/W6605767505"],"related_works":["https://openalex.org/W2313912803","https://openalex.org/W2415313185","https://openalex.org/W2085001324","https://openalex.org/W2396687134","https://openalex.org/W2216266735","https://openalex.org/W2028538562","https://openalex.org/W2015623363","https://openalex.org/W2127215398","https://openalex.org/W958410617","https://openalex.org/W2167393318"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,7,71,76,173,202],"oxygenation":[3],"in":[4,13,20,32,35,44,78,86,95,100,128,143,154,159,164,170,183,213],"the":[5,45,79,109,113,122,139,144,155,160,187],"pathogenesis":[6],"alcoholic":[8],"liver":[9,30,123,206],"injury":[10,207],"was":[11,41,105,136,148],"investigated":[12],"six":[14,21],"baboons":[15,214],"fed":[16,26,102,215],"alcohol":[17,27,101,216],"chronically":[18],"and":[19,48,73,176,190],"pair-fed":[22],"controls.":[23],"All":[24],"animals":[25,130],"developed":[28],"fatty":[29],"with,":[31],"addition,":[33],"fibrosis":[34],"three.":[36],"No":[37],"evidence":[38],"for":[39],"hypoxia":[40],"found,":[42],"both":[43],"basal":[46],"state":[47],"after":[49,138],"ethanol":[50,83,111,141,211],"at":[51],"moderate":[52,110],"(30":[53],"mM)":[54,58],"or":[55,64],"high":[56,140,210],"(55":[57],"levels,":[59],"as":[60],"shown":[61],"by":[62,91,118,209],"unchanged":[63],"even":[65],"increased":[66],"hepatic":[67],"venous":[68],"partial":[69],"pressure":[70],"O2":[72,74,88,115,193,197,203],"saturation":[75],"hemoglobin":[77],"tissue.":[80],"In":[81],"controls,":[82],"administration":[84],"resulted":[85],"enhanced":[87],"consumption":[89,198],"(offset":[90],"a":[92,133,151],"commitant":[93],"increase":[94,127],"splanchnic":[96,171],"blood":[97],"flow),":[98],"whereas":[99,132],"animals,":[103],"there":[104],"no":[106],"increase.":[107],"At":[108],"dose,":[112],"flow-independent":[114],"extraction,":[116],"measured":[117],"reflectance":[119],"spectroscopy":[120],"on":[121],"surface,":[124],"tended":[125],"to":[126],"control":[129],"only,":[131],"significant":[134],"decrease":[135],"observed":[137],"dose":[142],"alcohol-treated":[145],"baboons.":[146],"This":[147],"associated":[149],"with":[150,167],"marked":[152],"shift":[153],"mitochondrial":[156,179,188],"redox":[157],"level":[158],"alcohol-fed":[161],"(but":[162],"not":[163],"control)":[165],"baboons,":[166],"striking":[168],"rises":[169],"output":[172],"glutamic":[174],"dehydrogenase":[175],"acetaldehyde,":[177,182],"reflecting":[178],"injury.":[180],"Increased":[181],"turn,":[184],"may":[185],"aggravate":[186],"damage":[189],"exacerbate":[191],"defective":[192],"utilization.":[194],"Thus":[195],"impaired":[196],"rather":[199],"than":[200],"lack":[201],"supply":[204],"characterizes":[205],"produced":[208],"levels":[212],"chronically.":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
