{"id":"https://openalex.org/W2009374351","doi":"https://doi.org/10.1016/0035-9203(87)90156-8","title":"Failure of high dose mebendazole as a microfilaricide in patients with loiasis","display_name":"Failure of high dose mebendazole as a microfilaricide in patients with loiasis","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2009374351","doi":"https://doi.org/10.1016/0035-9203(87)90156-8","mag":"2009374351","pmid":"https://pubmed.ncbi.nlm.nih.gov/3318018"},"language":"en","primary_location":{"id":"doi:10.1016/0035-9203(87)90156-8","doi":"https://doi.org/10.1016/0035-9203(87)90156-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0035-9203(87)90156-8","pdf_url":null,"source":{"id":"https://openalex.org/S129317210","display_name":"Transactions of the Royal Society of Tropical Medicine and Hygiene","issn_l":"0035-9203","issn":["0035-9203","1878-3503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the Royal Society of Tropical Medicine and Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105024509","display_name":"G. D. Burchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313378897","display_name":"Albert Schweitzer Hospital","ror":"https://ror.org/028xtgx62","country_code":"GA","type":"healthcare","lineage":["https://openalex.org/I1313378897"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE","GA"],"is_corresponding":false,"raw_author_name":"G.D. Burchard","raw_affiliation_strings":["Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon","Bernhard-Nocht-Institut f\u00fcr Schiffs- und Tropenkrankheiten, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon","institution_ids":["https://openalex.org/I1313378897"]},{"raw_affiliation_string":"Bernhard-Nocht-Institut f\u00fcr Schiffs- und Tropenkrankheiten, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111493480","display_name":"Peter Kern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313378897","display_name":"Albert Schweitzer Hospital","ror":"https://ror.org/028xtgx62","country_code":"GA","type":"healthcare","lineage":["https://openalex.org/I1313378897"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE","GA"],"is_corresponding":false,"raw_author_name":"P. Kern","raw_affiliation_strings":["Bernhard-Nocht-Institut f\u00fcr Schiffs- und Tropenkrankheiten, Hamburg, Germany","Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard-Nocht-Institut f\u00fcr Schiffs- und Tropenkrankheiten, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon","institution_ids":["https://openalex.org/I1313378897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2326,"currency":"GBP","value_usd":3067},"apc_paid":null,"fwci":1.3912,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.82326352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"81","issue":"3","first_page":"420","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mebendazole","display_name":"mebendazole","score":0.9800000190734863},{"id":"https://openalex.org/keywords/loiasis","display_name":"loiasis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/loa-loa","display_name":"Loa loa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/microfilarial-density","display_name":"microfilarial density","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anthelmintic-treatment","display_name":"anthelmintic treatment","score":0.7179999947547913},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2779061029","wikidata":"https://www.wikidata.org/wiki/Q422194","display_name":"Mebendazole","level":2,"score":0.9948886632919312},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5810562968254089},{"id":"https://openalex.org/C2779726973","wikidata":"https://www.wikidata.org/wiki/Q578994","display_name":"Helminthiasis","level":2,"score":0.5649914741516113},{"id":"https://openalex.org/C2776908094","wikidata":"https://www.wikidata.org/wiki/Q572294","display_name":"Anthelmintic","level":2,"score":0.5329084992408752},{"id":"https://openalex.org/C2776031002","wikidata":"https://www.wikidata.org/wiki/Q134361","display_name":"Loa loa","level":4,"score":0.47547903656959534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4703614413738251},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35655516386032104},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.3446441888809204},{"id":"https://openalex.org/C2777629521","wikidata":"https://www.wikidata.org/wiki/Q815753","display_name":"Filariasis","level":3,"score":0.311592161655426},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.2893652319908142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2713627517223358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22442442178726196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2021051049232483},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.05907529592514038}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005368","descriptor_name":"Filariasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008118","descriptor_name":"Loiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008463","descriptor_name":"Mebendazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008463","descriptor_name":"Mebendazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0035-9203(87)90156-8","doi":"https://doi.org/10.1016/0035-9203(87)90156-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0035-9203(87)90156-8","pdf_url":null,"source":{"id":"https://openalex.org/S129317210","display_name":"Transactions of the Royal Society of Tropical Medicine and Hygiene","issn_l":"0035-9203","issn":["0035-9203","1878-3503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the Royal Society of Tropical Medicine and Hygiene","raw_type":"journal-article"},{"id":"pmid:3318018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3318018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the Royal Society of Tropical Medicine and Hygiene","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2069872105","https://openalex.org/W2104777020","https://openalex.org/W4240079676","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2410075422","https://openalex.org/W4386215483","https://openalex.org/W2295801842","https://openalex.org/W1449983952","https://openalex.org/W2130914472","https://openalex.org/W2002266144","https://openalex.org/W2008090908","https://openalex.org/W4417202191","https://openalex.org/W2104777020","https://openalex.org/W2084747469"],"abstract_inverted_index":{"The":[0,13],"effectiveness":[1],"of":[2,45],"mebendazole":[3,36],"as":[4],"a":[5],"microfilaricide":[6],"in":[7,24],"patients":[8],"with":[9],"loiasis":[10],"was":[11,16,33],"studied.":[12],"drug":[14],"regimen":[15],"1":[17],"g":[18],"twice":[19],"daily":[20],"for":[21],"21":[22],"days":[23],"adults.":[25],"During":[26],"and":[27],"after":[28],"treatment,":[29],"the":[30,42],"microfilarial":[31,43],"density":[32,44],"unchanged.":[34],"Therefore,":[35],"has":[37],"no":[38],"direct":[39],"effect":[40],"on":[41],"Loa":[46],"loa.":[47]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}