{"id":"https://openalex.org/W2009369296","doi":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","title":"Twenty-five percent albumin prevents lung injury following shock/resuscitation","display_name":"Twenty-five percent albumin prevents lung injury following shock/resuscitation","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2009369296","doi":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","mag":"2009369296","pmid":"https://pubmed.ncbi.nlm.nih.gov/14501967"},"language":"en","primary_location":{"id":"doi:10.1097/01.ccm.0000084846.45830.aa","doi":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059375772","display_name":"Kinga A. Powers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Kinga A. Powers","raw_affiliation_strings":["Department of Surgery, University Health Network, Toronto, Canada","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055198525","display_name":"Andr\u00e1s Kap\u00f9s","orcid":"https://orcid.org/0000-0002-6610-9530","observed_orcids":["https://orcid.org/0000-0002-6610-9530"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Andras Kapus","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068953495","display_name":"Rachel G. Khadaroo","orcid":"https://orcid.org/0000-0003-4918-5002","observed_orcids":["https://orcid.org/0000-0003-4918-5002"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Rachel G. Khadaroo","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060167816","display_name":"Ruijuan He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Ruijuan He","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John C. Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"John C. Marshall","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020734676","display_name":"Thomas F. Lindsay","orcid":"https://orcid.org/0000-0002-0615-9229","observed_orcids":["https://orcid.org/0000-0002-0615-9229"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Thomas F. Lindsay","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004819829","display_name":"Ori David Rotstein","orcid":"https://orcid.org/0009-0004-4388-5352","observed_orcids":["https://orcid.org/0009-0004-4388-5352","https://orcid.org/0000-0003-4339-7805"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]},{"id":"https://openalex.org/I4405263517","display_name":"Observatoire des Programmes Communautaires de D\u00e9veloppement Rural","ror":"https://ror.org/026jydx17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4405263517"]}],"countries":["CA","FR"],"is_corresponding":true,"raw_author_name":"Ori D. Rotstein","raw_affiliation_strings":["From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","Canada","ODR)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery, University Health Network and the University of Toronto (KAP, AK, RGK, RH, JCM, TFL), Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"and the Division of General Surgery, Toronto General Hospital (JCM, ODR)","institution_ids":["https://openalex.org/I2801845744"]},{"raw_affiliation_string":"Canada","institution_ids":[]},{"raw_affiliation_string":"ODR)","institution_ids":["https://openalex.org/I4405263517"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004819829"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801845744","https://openalex.org/I4405263517"],"apc_list":null,"apc_paid":null,"fwci":5.8645,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96057012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"9","first_page":"2355","last_page":"2363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.3594000041484833,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.953000009059906},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.49399998784065247},{"id":"https://openalex.org/keywords/resuscitation-fluids","display_name":"resuscitation fluids","score":0.8309999704360962},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lps-induced-lung-injury","display_name":"lipopolysaccharide-induced lung injury","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lactated-ringer-s-solution","display_name":"lactated Ringer's solution","score":0.8169999718666077},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/n-ethylmaleimide","display_name":"N-ethylmaleimide","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neutrophil-chemoattractants","display_name":"neutrophil chemoattractants","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.5659999847412109},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.8740925788879395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8600298166275024},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.7087231278419495},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6240196824073792},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5831361413002014},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5267221927642822},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4957607686519623},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.46290645003318787},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4487607777118683},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3050910234451294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26447394490242004},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.14645916223526}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.ccm.0000084846.45830.aa","doi":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000084846.45830.aa","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:14501967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14501967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W37545008","https://openalex.org/W90782821","https://openalex.org/W105279024","https://openalex.org/W1486368457","https://openalex.org/W1554783366","https://openalex.org/W1558349166","https://openalex.org/W1568529372","https://openalex.org/W1611625030","https://openalex.org/W1902960727","https://openalex.org/W1965267927","https://openalex.org/W1966368391","https://openalex.org/W1977428738","https://openalex.org/W1980570225","https://openalex.org/W1984006139","https://openalex.org/W1985423911","https://openalex.org/W1994316927","https://openalex.org/W1997093722","https://openalex.org/W1997261857","https://openalex.org/W2001217418","https://openalex.org/W2005675346","https://openalex.org/W2007665507","https://openalex.org/W2012991711","https://openalex.org/W2043230064","https://openalex.org/W2044051878","https://openalex.org/W2047562420","https://openalex.org/W2053468540","https://openalex.org/W2064892671","https://openalex.org/W2069642844","https://openalex.org/W2077092048","https://openalex.org/W2081081088","https://openalex.org/W2094045196","https://openalex.org/W2098407049","https://openalex.org/W2106958855","https://openalex.org/W2124805870","https://openalex.org/W2129198157","https://openalex.org/W2262384333","https://openalex.org/W2330331754","https://openalex.org/W4211146992"],"related_works":["https://openalex.org/W2079870004","https://openalex.org/W2354945856","https://openalex.org/W1963763711","https://openalex.org/W2138016504","https://openalex.org/W2373396705","https://openalex.org/W1967613775","https://openalex.org/W2775208068","https://openalex.org/W2088059234","https://openalex.org/W2348192018","https://openalex.org/W2016207834"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1,155,242],"evaluate":[2],"novel":[3,359],"indications":[4],"for":[5,65,107,157,351,361],"the":[6,13,26,117,158,228,244,251,342,352],"use":[7],"of":[8,17,56,75,97,116,124,135,145,152,161,181,199,204,230,247,253,262,341],"human":[9,30,147],"albumin":[10,31,137,148,163,179,216,286,290,321,344,363],"solutions":[11],"in":[12,47,60,69,103,201,295,325,368],"prevention":[14],"and":[15,23,101,227,278],"treatment":[16],"acute":[18,57,373],"lung":[19,45,58,67,315,323],"injury":[20,46,59,68,232,324],"following":[21,284],"shock/resuscitation":[22],"to":[24,71,92,334,347],"test":[25,156],"hypothesis":[27],"that":[28],"25%":[29,136,162,178,215,285,289,304,320,343,362],"is":[32],"an":[33,40,121,165,311,365],"effective":[34],"resuscitation":[35,170,235],"fluid":[36,224],"as":[37,39,164,257,259,297,364,372],"well":[38,258],"immunomodulatory":[41],"agent":[42,367],"protective":[43],"against":[44],"our":[48],"model.":[49,328],"DESIGN:":[50],"A":[51],"previously":[52],"developed":[53],"rodent":[54],"model":[55],"which":[61],"resuscitated":[62,113],"shock":[63,105],"primes":[64],"increased":[66],"response":[70],"a":[72,93,104,150,358],"small":[73],"dose":[74],"intratracheal":[76],"lipopolysaccharide.":[77],"SETTING:":[78],"University-affiliated":[79],"hospital.":[80],"SUBJECTS:":[81],"Sprague":[82],"Dawley":[83],"rats":[84],"weighing":[85],"300-350":[86],"g.":[87],"INTERVENTIONS:":[88],"Animals":[89,110],"were":[90,112,282],"bled":[91],"mean":[94],"arterial":[95,188],"pressure":[96,189],"40":[98],"mm":[99],"Hg":[100],"maintained":[102],"phase":[106],"1":[108],"hr.":[109],"then":[111],"by":[114,185,299],"transfusion":[115],"shed":[118,129,140],"blood":[119,130,141],"plus":[120,131,142],"equal":[122],"volume":[123,134],"Ringer's":[125,172,237],"lactate":[126,173,238],"or":[127,138,177,239],"their":[128,139],"3":[132],"mL/kg":[133,144],"15":[143],"5%":[146,240],"over":[149],"period":[151],"2":[153],"hrs.":[154],"possible":[159],"role":[160,360],"antioxidant,":[166],"we":[167],"also":[168],"performed":[169],"with":[171,175,214,234,236,319],"supplemented":[174],"N-acetylcysteine":[176],"depleted":[180],"its":[182,263],"antioxidant":[183,308,339],"properties":[184,340],"N-ethylmaleimide.":[186],"Mean":[187],"was":[190,206,269,332],"monitored":[191],"continuously.":[192],"One":[193],"hour":[194],"after":[195],"resuscitation,":[196],"100":[197],"microg":[198],"lipopolysaccharide":[200],"200":[202],"microL":[203],"saline":[205],"administered":[207],"intratracheally.":[208],"MEASUREMENTS":[209],"AND":[210],"MAIN":[211],"RESULTS:":[212],"Resuscitation":[213,318],"significantly":[217,291],"reduced":[218,335],"transpulmonary":[219],"protein":[220],"flux,":[221],"bronchoalveolar":[222],"lavage":[223],"neutrophil":[225,255,273,336],"counts,":[226],"degree":[229],"histopathological":[231],"compared":[233],"albumin.":[241],"delineate":[243],"underlying":[245],"mechanism":[246],"this":[248,326],"beneficial":[249,330],"effect,":[250],"production":[252],"cytokine-induced":[254,272],"chemoattractant":[256,274],"nuclear":[260,267,279],"translocation":[261,281],"critical":[264],"transcription":[265],"factor":[266],"factor-kappaB":[268,280],"measured.":[270],"Both":[271],"messenger":[275],"RNA":[276],"concentrations":[277],"diminished":[283],"resuscitation.":[287],"Furthermore,":[288],"decreased":[292],"lipid":[293],"peroxidation":[294],"plasma":[296],"measured":[298],"8-isoprostane":[300],"concentrations.":[301],"N-ethylmaleimide":[302],"modified":[303],"albumin,":[305],"possessing":[306],"lesser":[307],"activity,":[309],"exhibited":[310],"attenuated":[312],"protection":[313],"from":[314],"injury.":[316],"CONCLUSIONS:":[317],"attenuates":[322],"rat":[327],"The":[329,338],"effect":[331],"due":[333],"sequestration.":[337],"preparation":[345],"appeared":[346],"be":[348],"partially":[349],"responsible":[350],"effects":[353],"observed.":[354],"These":[355],"studies":[356],"suggest":[357],"anti-inflammatory":[366],"neutrophil-mediated":[369],"diseases,":[370],"such":[371],"respiratory":[374],"distress":[375],"syndrome.":[376]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}