{"id":"https://openalex.org/W2009368407","doi":"https://doi.org/10.1016/s0014-2999(00)00119-9","title":"Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2","display_name":"Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2009368407","doi":"https://doi.org/10.1016/s0014-2999(00)00119-9","mag":"2009368407","pmid":"https://pubmed.ncbi.nlm.nih.gov/10748266"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(00)00119-9","doi":"https://doi.org/10.1016/s0014-2999(00)00119-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00119-9","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102710291","display_name":"Tomohiro Terada","orcid":"https://orcid.org/0000-0002-4559-9753","observed_orcids":["https://orcid.org/0000-0002-4559-9753"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Terada","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007276836","display_name":"Jun Wada","orcid":"https://orcid.org/0000-0003-1468-5170","observed_orcids":["https://orcid.org/0000-0003-1468-5170"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Sawada","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101664787","display_name":"Hideyuki Saito","orcid":"https://orcid.org/0000-0001-6522-7300","observed_orcids":["https://orcid.org/0000-0001-6522-7300"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Saito","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109475659","display_name":"Yukiya Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiya Hashimoto","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113930950","display_name":"Ken-ichi Inui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ken-ichi Inui","raw_affiliation_strings":["Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113930950"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210150196"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.3864,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80781454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"392","issue":"1-2","first_page":"11","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nateglinide","display_name":"nateglinide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pept1","display_name":"PepT1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pept2","display_name":"PEPT2","score":1.0},{"id":"https://openalex.org/keywords/peptide-transporters","display_name":"peptide transporters","score":0.9380000233650208},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5979999899864197},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/insulin-secretagogues","display_name":"insulin secretagogues","score":0.6340000033378601},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9259999990463257},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.7710000276565552},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2779463123","wikidata":"https://www.wikidata.org/wiki/Q2254797","display_name":"Nateglinide","level":4,"score":0.9288411140441895},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.7061647176742554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5742009878158569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5418215394020081},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.465806782245636},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4636693000793457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.330488920211792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2827228903770447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.278539776802063},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.22557100653648376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2161092758178711},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15330737829208374},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.14657557010650635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074011","descriptor_name":"Peptide Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077715","descriptor_name":"Nateglinide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(00)00119-9","doi":"https://doi.org/10.1016/s0014-2999(00)00119-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00119-9","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:10748266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10748266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W629042179","https://openalex.org/W1486882165","https://openalex.org/W1504507024","https://openalex.org/W1535854627","https://openalex.org/W1578327318","https://openalex.org/W1584680823","https://openalex.org/W1896305083","https://openalex.org/W1971717447","https://openalex.org/W1976297946","https://openalex.org/W1991948319","https://openalex.org/W1997317812","https://openalex.org/W2008166341","https://openalex.org/W2010112736","https://openalex.org/W2011750387","https://openalex.org/W2018076581","https://openalex.org/W2019325232","https://openalex.org/W2037413729","https://openalex.org/W2075282068","https://openalex.org/W2082245792","https://openalex.org/W2088105909","https://openalex.org/W2128635872","https://openalex.org/W2142310683","https://openalex.org/W2155084075","https://openalex.org/W2174104157","https://openalex.org/W2265231634","https://openalex.org/W2266317072","https://openalex.org/W2305363331","https://openalex.org/W2321939296","https://openalex.org/W4205818900","https://openalex.org/W4406382266","https://openalex.org/W6639705328","https://openalex.org/W6682546993","https://openalex.org/W6685242858","https://openalex.org/W6693441727","https://openalex.org/W6876453085"],"related_works":["https://openalex.org/W2084158307","https://openalex.org/W2090937790","https://openalex.org/W1997317812","https://openalex.org/W2071917228","https://openalex.org/W2951770840","https://openalex.org/W1994721865","https://openalex.org/W2082281371","https://openalex.org/W7098740859","https://openalex.org/W2101059949","https://openalex.org/W2331421467"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}