{"id":"https://openalex.org/W2009347249","doi":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","title":"Retroviral Rebound Syndrome after Cessation of Suppressive Antiretroviral Therapy in Three Patients with Chronic HIV Infection","display_name":"Retroviral Rebound Syndrome after Cessation of Suppressive Antiretroviral Therapy in Three Patients with Chronic HIV Infection","publication_year":2000,"publication_date":"2000-09-19","ids":{"openalex":"https://openalex.org/W2009347249","doi":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","mag":"2009347249","pmid":"https://pubmed.ncbi.nlm.nih.gov/10975960"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-133-6-200009190-00010","doi":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040818748","display_name":"Roy M. Colven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I4210147181","display_name":"Harvard Vanguard Medical Associates","ror":"https://ror.org/03hwmxn85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy Colven","raw_affiliation_strings":["From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","From Harborview Medical Center, Seattle, Washington","Harvard Vanguard Medical Associates, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"]},{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington","institution_ids":["https://openalex.org/I2802336062"]},{"raw_affiliation_string":"Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210147181"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert D. Harrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I4210147181","display_name":"Harvard Vanguard Medical Associates","ror":"https://ror.org/03hwmxn85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Harrington","raw_affiliation_strings":["From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David H. Spach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I4210147181","display_name":"Harvard Vanguard Medical Associates","ror":"https://ror.org/03hwmxn85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Spach","raw_affiliation_strings":["From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110140901","display_name":"Calvin\u00a0J. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I4210147181","display_name":"Harvard Vanguard Medical Associates","ror":"https://ror.org/03hwmxn85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calvin J. Cohen","raw_affiliation_strings":["From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"]}]},{"author_position":"last","author":{"id":null,"display_name":"Thomas M. Hooton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I4210147181","display_name":"Harvard Vanguard Medical Associates","ror":"https://ror.org/03hwmxn85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Hooton","raw_affiliation_strings":["From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Harborview Medical Center, Seattle, Washington; and Harvard Vanguard Medical Associates, Boston, Massachusetts","institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040818748"],"corresponding_institution_ids":["https://openalex.org/I2802336062","https://openalex.org/I4210147181"],"apc_list":null,"apc_paid":null,"fwci":2.4605,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.8955095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"133","issue":"6","first_page":"430","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antiretroviral-therapy-discontinuation","display_name":"antiretroviral therapy discontinuation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/viral-rebound","display_name":"viral rebound","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.7110000252723694},{"id":"https://openalex.org/keywords/plasma-hiv-rna","display_name":"plasma HIV RNA","score":0.796999990940094},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9193263649940491},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6162725687026978},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5996332764625549},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49289917945861816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46332377195358276},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.4127037525177002},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.39528852701187134}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-133-6-200009190-00010","doi":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-133-6-200009190-00010","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:10975960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1655510925","https://openalex.org/W2008972159","https://openalex.org/W2016727132","https://openalex.org/W2036098428","https://openalex.org/W2046822741","https://openalex.org/W2057516022","https://openalex.org/W2103182811","https://openalex.org/W2150650094","https://openalex.org/W2314893245","https://openalex.org/W2414236650"],"related_works":["https://openalex.org/W2108704460","https://openalex.org/W4233259237","https://openalex.org/W2074324994","https://openalex.org/W2168795464","https://openalex.org/W4300144377","https://openalex.org/W2394490552","https://openalex.org/W1979000541","https://openalex.org/W2084513807","https://openalex.org/W2260840748","https://openalex.org/W3080391012"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"viral":[2],"rebound":[3,154],"follows":[4],"cessation":[5,30,80,173],"of":[6,31,81,117,140,174],"suppressive":[7,62,175],"antiretroviral":[8,33,63,82,90,127,176],"therapy":[9,34,128],"in":[10,35,47,110,115,122,136,145,160,166],"chronic":[11,36,57,169],"HIV":[12,37,44,58,69,102,111,141,162,170],"infection,":[13],"a":[14,25,95,100,107,120],"viremic":[15],"clinical":[16,96],"syndrome":[17,27,155,163],"has":[18],"not":[19],"been":[20],"described.":[21],"OBJECTIVE:":[22],"To":[23],"describe":[24],"retroviral":[26,153],"associated":[28],"with":[29,56,106,138,168],"effective":[32],"infection.":[38],"DESIGN:":[39],"Case":[40],"reports.":[41],"SETTING:":[42],"Outpatient":[43],"specialty":[45],"clinics":[46],"Seattle,":[48],"Washington,":[49],"and":[50,72,78,143],"Boston,":[51],"Massachusetts.":[52],"PATIENTS:":[53],"Three":[54],"patients":[55,167],"infection":[59,171],"who":[60],"discontinued":[61],"therapy.":[64,83,177],"MEASUREMENTS:":[65],"Clinical":[66],"course,":[67],"plasma":[68],"RNA":[70,112,142],"levels,":[71],"CD4":[73,123,146],"cell":[74,124,147],"counts":[75],"before,":[76],"during,":[77],"after":[79,88,172],"RESULTS:":[84],"Within":[85],"6":[86],"weeks":[87],"stopping":[89],"therapy,":[91],"each":[92,131],"patient":[93],"experienced":[94],"illness":[97],"that":[98,158],"resembled":[99],"primary":[101,161],"syndrome.":[103],"This":[104],"coincided":[105],"marked":[108],"increase":[109,144],"level":[113],"and,":[114],"two":[116],"three":[118],"patients,":[119],"decrease":[121],"count.":[125],"After":[126],"was":[129],"restarted,":[130],"patient's":[132],"symptoms":[133],"rapidly":[134],"resolved":[135],"association":[137],"resuppression":[139],"count":[148],"or":[149],"percentage.":[150],"CONCLUSION:":[151],"A":[152],"similar":[156],"to":[157],"seen":[159],"can":[164],"occur":[165]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}