{"id":"https://openalex.org/W2009340955","doi":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","title":"Mutations in catB , the Gene Encoding Muconate Cycloisomerase, Activate Transcription of the Distal ben Genes and Contribute to a Complex Regulatory Circuit in Acinetobacter sp. Strain ADP1","display_name":"Mutations in catB , the Gene Encoding Muconate Cycloisomerase, Activate Transcription of the Distal ben Genes and Contribute to a Complex Regulatory Circuit in Acinetobacter sp. Strain ADP1","publication_year":2000,"publication_date":"2000-12-15","ids":{"openalex":"https://openalex.org/W2009340955","doi":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","mag":"2009340955","pmid":"https://pubmed.ncbi.nlm.nih.gov/11092867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/94832"},"language":"en","primary_location":{"id":"doi:10.1128/jb.182.24.7044-7052.2000","doi":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC94832","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090104776","display_name":"Nathaniel J. Cosper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel J. Cosper","raw_affiliation_strings":["<!--label omitted: 1-->Center for Metalloenzyme Studies,1","<!--label omitted: 2-->Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","Center for Metalloenzyme Studies,1","Department of Chemistry,2 University of Georgia, Athens, Georgia 30602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 2-->Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030032530","display_name":"Lauren S. Collier-Hyams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren S. Collier","raw_affiliation_strings":["<!--label omitted: 3-->Department of Microbiology,3 and","Department of Microbiology,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Department of Microbiology,3 and","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology,3 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079486462","display_name":"Todd J. Clark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd J. Clark","raw_affiliation_strings":["<!--label omitted: 3-->Department of Microbiology,3 and","Department of Microbiology,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Department of Microbiology,3 and","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology,3 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067984508","display_name":"Robert A. Scott","orcid":"https://orcid.org/0000-0003-2236-1336","observed_orcids":["https://orcid.org/0000-0003-2236-1336","https://orcid.org/0000-0001-9822-7825"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Scott","raw_affiliation_strings":["<!--label omitted: 1-->Center for Metalloenzyme Studies,1","<!--label omitted: 2-->Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","Center for Metalloenzyme Studies,1","Department of Chemistry,2 University of Georgia, Athens, Georgia 30602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 2-->Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry,2 University of Georgia, Athens, Georgia 30602","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030250396","display_name":"Ellen L. Neidle","orcid":"https://orcid.org/0000-0003-1665-5303","observed_orcids":["https://orcid.org/0000-0003-1665-5303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen L. Neidle","raw_affiliation_strings":["<!--label omitted: 1-->Center for Metalloenzyme Studies,1","<!--label omitted: 3-->Department of Microbiology,3 and","Center for Metalloenzyme Studies,1","Department of Microbiology,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 3-->Department of Microbiology,3 and","institution_ids":[]},{"raw_affiliation_string":"Center for Metalloenzyme Studies,1","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology,3 and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4635,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80697705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"182","issue":"24","first_page":"7044","last_page":"7052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cis-cis-muconate","display_name":"cis,cis-muconate","score":0.972000002861023},{"id":"https://openalex.org/keywords/catechol-1-2-dioxygenase","display_name":"catechol 1,2-dioxygenase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/benzoate-degradation","display_name":"benzoate degradation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/enzyme-catalytic-properties","display_name":"enzyme catalytic properties","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8355265855789185},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.787142276763916},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6549964547157288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.616833508014679},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.5274301171302795},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5208916664123535},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5042420625686646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4855513274669647},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4601486325263977},{"id":"https://openalex.org/C170344550","wikidata":"https://www.wikidata.org/wiki/Q311359","display_name":"lac operon","level":4,"score":0.4316338002681732},{"id":"https://openalex.org/C5527404","wikidata":"https://www.wikidata.org/wiki/Q2357310","display_name":"Structural gene","level":4,"score":0.4270186722278595},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3854643702507019},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3798334300518036},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000150","descriptor_name":"Acinetobacter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000150","descriptor_name":"Acinetobacter","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000150","descriptor_name":"Acinetobacter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019753","descriptor_name":"Intramolecular Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019753","descriptor_name":"Intramolecular Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019753","descriptor_name":"Intramolecular Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.182.24.7044-7052.2000","doi":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.182.24.7044-7052.2000","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:193754","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC94832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:94832","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/94832","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:11092867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11092867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:193754","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC94832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1509557781","https://openalex.org/W1546783991","https://openalex.org/W1580575171","https://openalex.org/W1632125056","https://openalex.org/W1698934341","https://openalex.org/W1734366244","https://openalex.org/W1745838399","https://openalex.org/W1893340548","https://openalex.org/W1967164846","https://openalex.org/W1972010400","https://openalex.org/W1991422330","https://openalex.org/W1992016838","https://openalex.org/W2028231353","https://openalex.org/W2028622989","https://openalex.org/W2074283351","https://openalex.org/W2080528351","https://openalex.org/W2097321270","https://openalex.org/W2098305009","https://openalex.org/W2128635872","https://openalex.org/W2141600679","https://openalex.org/W2141811339","https://openalex.org/W2144634347","https://openalex.org/W2153347665","https://openalex.org/W2169334907","https://openalex.org/W2208669225","https://openalex.org/W2210027807","https://openalex.org/W2323778292","https://openalex.org/W6670481114"],"related_works":["https://openalex.org/W2169334907","https://openalex.org/W2114521600","https://openalex.org/W1581681869","https://openalex.org/W1626863135","https://openalex.org/W2065143304","https://openalex.org/W1698934341","https://openalex.org/W2114657547","https://openalex.org/W2001272693","https://openalex.org/W2006103378","https://openalex.org/W1844454187"],"abstract_inverted_index":{"Mutants":[0],"of":[1,32,127,156,233,242,251,267,280],"the":[2,15,20,33,96,107,111,124,128,157,175,243,247,252,263,277],"bacterium":[3],"Acinetobacter":[4],"sp.":[5],"strain":[6],"ADP1":[7],"were":[8,65,121,142,237,254],"selected":[9],"to":[10,25,29,49,67,104,146,201,207,215,217,240,262],"grow":[11],"on":[12,75,153,184],"benzoate":[13,26,40,48,85,285],"without":[14],"BenM":[16,23,202],"transcriptional":[17,140,290],"activator.":[18],"In":[19,59],"wild":[21,108,129,244],"type,":[22],"responds":[24,214],"and":[27,110,131,144,205,269],"cis,cis-muconate":[28,216,268],"activate":[30,208,218],"expression":[31,164],"benABCDE":[34],"operon,":[35],"which":[36,174,256],"is":[37,90,171],"involved":[38],"in":[39,123,165,173,193,203,230,283],"catabolism.":[41,86],"This":[42],"operon":[43],"encodes":[44,78],"enzymes":[45],"that":[46,71,241],"convert":[47],"catechol,":[50],"a":[51,137,288],"compound":[52],"subsequently":[53],"degraded":[54],"by":[55,95],"cat":[56,219],"gene-encoded":[57],"enzymes.":[58],"this":[60,224],"report,":[61],"four":[62],"spontaneous":[63],"mutants":[64,236,253],"found":[66],"carry":[68],"catB":[69,77,112,149,158,176,235],"mutations":[70,150,159,177],"enabled":[72],"BenM-independent":[73],"growth":[74,152,183],"benzoate.":[76,154],"muconate":[79,133,179,226],"cycloisomerase,":[80],"an":[81,198],"enzyme":[82,116],"required":[83],"for":[84],"Its":[87],"substrate,":[88],"cis,cis-muconate,":[89],"enzymatically":[91],"produced":[92],"from":[93,106,259],"catechol":[94,98,248],"catA-encoded":[97],"1,2-dioxygenase.":[99],"Muconate":[100],"cycloisomerase":[101,180],"was":[102,117],"purified":[103,115],"homogeneity":[105],"type":[109,130],"mutants.":[113],"Each":[114],"active,":[118],"although":[119],"there":[120],"differences":[122],"catalytic":[125],"properties":[126],"variant":[132],"cycloisomerases.":[134],"Strains":[135],"with":[136,223],"chromosomal":[138],"benA::lacZ":[139],"fusion":[141],"constructed":[143],"used":[145],"investigate":[147],"how":[148],"affect":[151],"All":[155],"increased":[160],"cis,cis-muconate-activated":[161],"ben":[162,209],"gene":[163,210,220],"strains":[166],"lacking":[167],"BenM.":[168],"A":[169],"model":[170],"presented":[172],"reduce":[178],"activity":[181],"during":[182],"benzoate,":[185],"thereby":[186],"increasing":[187,270],"intracellular":[188,265],"cis,":[189],"cis-muconate":[190],"concentrations.":[191],"This,":[192],"turn,":[194],"may":[195,257],"allow":[196],"CatM,":[197],"activator":[199],"similar":[200],"sequence":[204],"function,":[206],"transcription.":[211],"CatM":[212,260],"normally":[213],"expression.":[221,272],"Consistent":[222],"model,":[225],"cylcoisomerase":[227],"specific":[228],"activities":[229,250],"cell":[231],"extracts":[232],"benzoate-grown":[234],"low":[238],"relative":[239],"type.":[245],"Moreover,":[246],"1,2-dioxygenase":[249],"elevated,":[255],"result":[258],"responding":[261],"altered":[264],"levels":[266],"catA":[271],"Collectively,":[273],"these":[274],"results":[275],"support":[276],"important":[278],"role":[279],"metabolite":[281],"concentrations":[282],"controlling":[284],"degradation":[286],"via":[287],"complex":[289],"regulatory":[291],"circuit.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}