{"id":"https://openalex.org/W2009253350","doi":"https://doi.org/10.1371/journal.pone.0001468","title":"A Microfluidic Device for Temporally Controlled Gene Expression and Long-Term Fluorescent Imaging in Unperturbed Dividing Yeast Cells","display_name":"A Microfluidic Device for Temporally Controlled Gene Expression and Long-Term Fluorescent Imaging in Unperturbed Dividing Yeast Cells","publication_year":2008,"publication_date":"2008-01-22","ids":{"openalex":"https://openalex.org/W2009253350","doi":"https://doi.org/10.1371/journal.pone.0001468","mag":"2009253350","pmid":"https://pubmed.ncbi.nlm.nih.gov/18213377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194624"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0001468","doi":"https://doi.org/10.1371/journal.pone.0001468","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001468","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001468&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001468&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083225830","display_name":"Gilles Charvin","orcid":"https://orcid.org/0000-0002-6852-6952","observed_orcids":["https://orcid.org/0000-0002-6852-6952"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gilles Charvin","raw_affiliation_strings":["Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, USA. gilles.charvin@gmail.com","Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, USA. gilles.charvin@gmail.com","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061209953","display_name":"Frederick R. Cross","orcid":"https://orcid.org/0000-0002-4387-4133","observed_orcids":["https://orcid.org/0000-0002-4387-4133"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick R. Cross","raw_affiliation_strings":["The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036408112","display_name":"Eric D. Siggia","orcid":"https://orcid.org/0000-0001-7482-1854","observed_orcids":["https://orcid.org/0000-0001-7482-1854"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Siggia","raw_affiliation_strings":["Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center For Studies in Physics and Biology, The Rockefeller University, New York, New York, United States of America","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083225830"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.4323,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.95814561,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"3","issue":"1","first_page":"e1468","last_page":"e1468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.07909999787807465,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidic-flow-cell","display_name":"microfluidic flow cell","score":0.9700000286102295},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9539999961853027},{"id":"https://openalex.org/keywords/single-cell-fluorescence-imaging","display_name":"single-cell fluorescence imaging","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5370000004768372},{"id":"https://openalex.org/keywords/transient-expression","display_name":"transient expression","score":0.7250000238418579},{"id":"https://openalex.org/keywords/inducible-promoters","display_name":"inducible promoters","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gal1-promoter","display_name":"GAL1 promoter","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cdc20","display_name":"CDC20","score":0.7860000133514404},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.49900001287460327},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7111155986785889},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5733802914619446},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5665448307991028},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5220763087272644},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.509711742401123},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.48836442828178406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4696615934371948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4319618344306946},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3641223907470703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3220614790916443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30259597301483154},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2349095344543457},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22874483466148376},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22057890892028809},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21693843603134155},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17195960879325867},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13208502531051636},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0001468","doi":"https://doi.org/10.1371/journal.pone.0001468","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001468","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001468&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2194624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:18213377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18213377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.836.6580","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.836.6580","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2194624%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00384163v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00384163","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2008, 3, pp.e1468","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:cc857e63d78a44c2af7fa53001e5474a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cc857e63d78a44c2af7fa53001e5474a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 3, Iss 1, p e1468 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/151274","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Microfluidic_Device_for_Temporally_Controlled_Gene_Expression_and_Long_Term_Fluorescent_Imaging_in_Unperturbed_Dividing_Yeast_Cells/151274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0001468","doi":"https://doi.org/10.1371/journal.pone.0001468","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001468","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001468&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6708185514","display_name":"Theoretical Condensed Matter Physics","funder_award_id":"0517138","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009253350.pdf","grobid_xml":"https://content.openalex.org/works/W2009253350.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1590458072","https://openalex.org/W1600651336","https://openalex.org/W1971955404","https://openalex.org/W1979420899","https://openalex.org/W2000456081","https://openalex.org/W2015038174","https://openalex.org/W2029361184","https://openalex.org/W2035230904","https://openalex.org/W2039210066","https://openalex.org/W2039808072","https://openalex.org/W2041797933","https://openalex.org/W2047076849","https://openalex.org/W2047300775","https://openalex.org/W2063856790","https://openalex.org/W2078285432","https://openalex.org/W2078477504","https://openalex.org/W2081107232","https://openalex.org/W2081298797","https://openalex.org/W2098941196","https://openalex.org/W2100866112","https://openalex.org/W2103453943","https://openalex.org/W2115734610","https://openalex.org/W2124918094","https://openalex.org/W2127068865","https://openalex.org/W2128104520","https://openalex.org/W2148323109","https://openalex.org/W2169805130","https://openalex.org/W2171416668","https://openalex.org/W2188142152"],"related_works":["https://openalex.org/W1988101537","https://openalex.org/W2402859649","https://openalex.org/W2025713466","https://openalex.org/W1851746200","https://openalex.org/W2123558418","https://openalex.org/W3111479944","https://openalex.org/W1986357095","https://openalex.org/W2765187945","https://openalex.org/W2035235490","https://openalex.org/W1616642469"],"abstract_inverted_index":{"BACKGROUND:":[0],"Imaging":[1],"single":[2,85],"cells":[3,57,101],"with":[4,84,87,122,181,188,252],"fluorescent":[5],"markers":[6],"over":[7,231],"multiple":[8],"cell":[9,23,33,70,132,178,186,208,242,249],"cycles":[10,180],"is":[11],"a":[12,67,108,130,135,190,198,232],"powerful":[13],"tool":[14],"for":[15,39,75,126],"unraveling":[16],"the":[17,22,26,46,91,160,185,219,253],"mechanism":[18],"and":[19,48,105,118,146,149,221],"dynamics":[20],"of":[21,42,50,90,137,156,223,241],"cycle.":[24],"Over":[25],"past":[27],"ten":[28],"years,":[29],"microfluidic":[30,68],"techniques":[31],"in":[32,54,107],"biology":[34],"have":[35],"emerged":[36],"that":[37,158,168],"allow":[38],"good":[40],"control":[41,47,159],"growth":[43,92],"environment.":[44],"Yet":[45],"quantification":[49],"transient":[51,150],"gene":[52,151,172],"expression":[53,152],"unperturbed":[55],"dividing":[56],"has":[58],"received":[59],"less":[60],"attention.":[61],"METHODOLOGY/PRINCIPAL":[62],"FINDINGS:":[63],"Here,":[64],"we":[65,143],"describe":[66],"flow":[69,89],"to":[71,134,206,216],"grow":[72,106],"Saccharomyces":[73],"Cerevisiae":[74],"more":[76,138],"than":[77,139],"8":[78],"generations":[79],"(approximately":[80],"12":[81],"hrs)":[82],"starting":[83],"cells,":[86,128],"controlled":[88],"medium.":[93],"This":[94],"setup":[95],"provides":[96],"two":[97],"important":[98],"features:":[99],"first,":[100],"are":[102],"tightly":[103],"confined":[104],"remarkably":[109],"planar":[110],"array.":[111],"The":[112,236],"pedigree":[113],"can":[114,144,175,213],"thus":[115],"be":[116,214],"determined":[117],"single-cell":[119],"fluorescence":[120],"measured":[121,254],"3":[123],"minutes":[124,171],"resolution":[125],"all":[127],"as":[129],"founder":[131],"grows":[133],"micro-colony":[136],"200":[140],"cells.":[141],"Second,":[142],"trigger":[145,192,200],"calibrate":[147],"rapid":[148],"using":[153],"reversible":[154],"administration":[155],"inducers":[157],"GAL1":[161],"or":[162,197,228,246,248],"MET3":[163],"promoters.":[164],"We":[165],"then":[166],"show":[167],"periodic":[169],"10-20":[170],"induction":[173],"pulses":[174],"drive":[176],"many":[177],"division":[179],"complete":[182],"coherence":[183],"across":[184],"cluster,":[187],"either":[189],"G1/S":[191],"(cln1":[193],"cln2":[194],"cln3":[195],"MET3-CLN2)":[196],"mitotic":[199],"(cdc20":[201],"GALL-CDC20).":[202],"CONCLUSIONS/SIGNIFICANCE:":[203],"In":[204],"addition":[205],"evident":[207],"cycle":[209,250],"applications,":[210],"this":[211],"device":[212],"used":[215],"directly":[217],"measure":[218],"amount":[220],"duration":[222],"any":[224],"fluorescently":[225],"scorable":[226],"signal-transduction":[227],"gene-induction":[229],"response":[230],"long":[233],"time":[234],"period.":[235],"system":[237],"allows":[238],"direct":[239],"correlation":[240],"history":[243],"(e.g.,":[244],"hysteresis":[245],"epigenetics)":[247],"position":[251],"response.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
