{"id":"https://openalex.org/W2009244491","doi":"https://doi.org/10.1096/fj.14-262733","title":"Inhibition of cholinergic pathways in Drosophila melanogaster by \u03b1\u2010conotoxins","display_name":"Inhibition of cholinergic pathways in Drosophila melanogaster by \u03b1\u2010conotoxins","publication_year":2014,"publication_date":"2014-12-02","ids":{"openalex":"https://openalex.org/W2009244491","doi":"https://doi.org/10.1096/fj.14-262733","mag":"2009244491","pmid":"https://pubmed.ncbi.nlm.nih.gov/25466886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422358"},"language":"en","primary_location":{"id":"doi:10.1096/fj.14-262733","doi":"https://doi.org/10.1096/fj.14-262733","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.14-262733","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033191848","display_name":"Mari D. Heghinian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari D. Heghinian","raw_affiliation_strings":["Department of Chemistry and Biochemistry Florida Atlantic University Boca Raton Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Florida Atlantic University Boca Raton Florida USA","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945939","display_name":"Monica Mejia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Mejia","raw_affiliation_strings":["Department of Biological Sciences Florida Atlantic University Boca Raton Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Florida Atlantic University Boca Raton Florida USA","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025386235","display_name":"David J. Adams","orcid":"https://orcid.org/0000-0002-7030-2288","observed_orcids":["https://orcid.org/0000-0002-7030-2288"]},"institutions":[{"id":"https://openalex.org/I82951845","display_name":"RMIT University","ror":"https://ror.org/04ttjf776","country_code":"AU","type":"education","lineage":["https://openalex.org/I82951845"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David J. Adams","raw_affiliation_strings":["Health Innovations Research Institute RMIT University Melbourne Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Innovations Research Institute RMIT University Melbourne Victoria Australia","institution_ids":["https://openalex.org/I82951845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020894647","display_name":"Tanja Angela Godenschwege","orcid":"https://orcid.org/0000-0003-3322-4134","observed_orcids":["https://orcid.org/0000-0003-3322-4134"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja A. Godenschwege","raw_affiliation_strings":["Department of Biological Sciences Florida Atlantic University Boca Raton Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Florida Atlantic University Boca Raton Florida USA","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027743731","display_name":"Frank Mar\u00ed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank Mar\u00ed","raw_affiliation_strings":["Department of Chemistry and Biochemistry Florida Atlantic University Boca Raton Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Florida Atlantic University Boca Raton Florida USA","institution_ids":["https://openalex.org/I63772739"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027743731"],"corresponding_institution_ids":["https://openalex.org/I63772739"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.5464,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63178014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"3","first_page":"1011","last_page":"1018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-conotoxins","display_name":"alpha-conotoxins","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dorsal-longitudinal-muscle","display_name":"dorsal longitudinal muscle","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cholinergic-pathways","display_name":"cholinergic pathways","score":0.7210000157356262},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.5600000023841858},{"id":"https://openalex.org/keywords/neurodegenerative-disease-models","display_name":"neurodegenerative disease models","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7325782179832458},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.7160966396331787},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6679717898368835},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.6030219793319702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5942201614379883},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.5201497673988342},{"id":"https://openalex.org/C2909754679","wikidata":"https://www.wikidata.org/wiki/Q2080426","display_name":"Nicotinic Antagonist","level":4,"score":0.4367189407348633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3945111930370331},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3792966604232788},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2868139445781708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2317177653312683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21791300177574158}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020916","descriptor_name":"Conotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052078","descriptor_name":"Conus Snail","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1096/fj.14-262733","doi":"https://doi.org/10.1096/fj.14-262733","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.14-262733","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4422358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:25466886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25466886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:ihmri-1606","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/ihmri/584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Illawarra Health and Medical Research Institute","raw_type":"article"},{"id":"pmh:oai:alma61RMIT.INST:11247915420001341","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.14-262733","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27480282","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Inhibition_of_cholinergic_pathways_in_Drosophila_melanogaster_by_-conotoxins/27480282","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4422358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1435098316","display_name":"Efficacious Screening of Peptidic Natural Products Using Drosophila","funder_award_id":"R21NS066371","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G247321238","display_name":null,"funder_award_id":"R21NS06637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4064469415","display_name":null,"funder_award_id":"R21NS06637","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W95014119","https://openalex.org/W100736258","https://openalex.org/W1503781574","https://openalex.org/W1637250296","https://openalex.org/W1977699952","https://openalex.org/W1978134461","https://openalex.org/W1983761344","https://openalex.org/W1985048795","https://openalex.org/W1991233263","https://openalex.org/W1992478688","https://openalex.org/W2001567877","https://openalex.org/W2001859078","https://openalex.org/W2003703108","https://openalex.org/W2015432354","https://openalex.org/W2029405062","https://openalex.org/W2029710875","https://openalex.org/W2030395075","https://openalex.org/W2040945433","https://openalex.org/W2044907489","https://openalex.org/W2052956415","https://openalex.org/W2056608021","https://openalex.org/W2071486470","https://openalex.org/W2072838806","https://openalex.org/W2074568561","https://openalex.org/W2076995634","https://openalex.org/W2097345469","https://openalex.org/W2104838343","https://openalex.org/W2106209907","https://openalex.org/W2120566679","https://openalex.org/W2125827897","https://openalex.org/W2127322768","https://openalex.org/W2128845098","https://openalex.org/W2132390947","https://openalex.org/W2154915448","https://openalex.org/W2155687897","https://openalex.org/W2158583969","https://openalex.org/W4213393259","https://openalex.org/W4244821183"],"related_works":["https://openalex.org/W2755344374","https://openalex.org/W1992478688","https://openalex.org/W2081147067","https://openalex.org/W2076995634","https://openalex.org/W2023010677","https://openalex.org/W2782095662","https://openalex.org/W1964014975","https://openalex.org/W7100095099","https://openalex.org/W2956036516","https://openalex.org/W1977699952"],"abstract_inverted_index":{"Nicotinic":[0],"acetylcholine":[1],"receptors":[2,138],"(nAChRs)":[3],"play":[4],"a":[5],"pivotal":[6],"role":[7],"in":[8,19,42,177,186,197],"synaptic":[9],"transmission":[10],"of":[11,50,68,71,78,123,126,153,156,167,193],"neuronal":[12,20,207],"signaling":[13],"pathways":[14,32],"and":[15,27,64,114],"are":[16],"fundamentally":[17],"involved":[18],"disorders,":[21],"including":[22],"Alzheimer's":[23],"disease,":[24,26],"Parkinson's":[25],"schizophrenia.":[28],"In":[29],"vertebrates,":[30],"cholinergic":[31,48],"can":[33],"be":[34],"selectively":[35],"inhibited":[36,56],"by":[37,57,171],"\u03b1-conotoxins;":[38],"we":[39,129],"show":[40],"that":[41,134],"the":[43,47,51,76,79,124,160,165,178,187,191],"model":[44],"organism":[45],"Drosophila,":[46],"component":[49],"giant":[52,80],"fiber":[53,81],"system":[54],"is":[55],"\u03b1-conotoxins":[58],"MII,":[59],"AuIB,":[60,98],"BuIA,":[61,103],"EI,":[62,108],"PeIA,":[63,113],"ImI.":[65,119],"The":[66],"injection":[67,152],"45":[69,154],"pmol/fly":[70,155],"each":[72],"toxin":[73],"dramatically":[74],"decreases":[75],"response":[77],"to":[82,88,147,163,200,205],"dorsal":[83],"longitudinal":[84],"muscle":[85],"(GF-DLM)":[86],"connection":[87],"20":[89],"\u00b1":[90,95,100,105,110,116,149],"13.9%":[91],"for":[92,97,102,107,112,118],"MII;":[93],"26":[94],"13.7%":[96],"12":[99],"9.9%":[101],"30":[104],"11.3%":[106],"1":[109],"1%":[111],"34":[115],"15.4%":[117],"Through":[120],"bioassay-guided":[121],"fractionation":[122],"venom":[125],"Conus":[127],"brunneus,":[128],"found":[130],"BruIB,":[131],"an":[132,196],"\u03b1-conotoxin":[133],"inhibits":[135],"Drosophila":[136,188,194],"nicotinic":[137],"but":[139],"not":[140],"its":[141,168],"vertebrate":[142,169],"counterparts.":[143],"GF-DLM":[144],"responses":[145],"decreased":[146],"43.7":[148],"8.02%":[150],"on":[151],"BruIB.":[157],"We":[158],"manipulated":[159],"D\u03b17":[161],"nAChR":[162],"mimic":[164],"selectivity":[166],"counterpart":[170],"placing":[172],"structurally":[173],"guided":[174],"point":[175],"mutations":[176],"conotoxin-binding":[179],"site.":[180],"This":[181],"manipulation":[182],"rendered":[183],"vertebrate-like":[184],"behavior":[185],"system,":[189],"enhancing":[190],"suitability":[192],"as":[195],"vivo":[198],"tool":[199],"carry":[201],"out":[202],"studies":[203],"related":[204],"human":[206],"diseases.":[208],".":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
