{"id":"https://openalex.org/W2009215324","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","title":"A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors","display_name":"A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2009215324","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","mag":"2009215324","pmid":"https://pubmed.ncbi.nlm.nih.gov/10430263"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990801%2986%3A3%3C528%3A%3AAID-CNCR23%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990801%2986%3A3%3C528%3A%3AAID-CNCR23%3E3.0.CO%3B2-R","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109997055","display_name":"Everett E. Vokes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Cancer Research Center, Chicago, Illinois","Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","Dr. Vokes received research support and acts as a consultant for Zeneca Pharmaceuticals and receives research support and is a speaker for Bristol Myers Squibb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Chicago, Illinois","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Dr. Vokes received research support and acts as a consultant for Zeneca Pharmaceuticals and receives research support and is a speaker for Bristol Myers Squibb","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043184297","display_name":"Boon Cher Goh","orcid":"https://orcid.org/0000-0002-4107-102X","observed_orcids":["https://orcid.org/0000-0002-4107-102X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boon C. Goh","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023380002","display_name":"DONNA C. BERTUCCI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Bertucci","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083513542","display_name":"Nicholas J. Vogelzang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Vogelzang","raw_affiliation_strings":["Cancer Research Center, Chicago, Illinois","Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Chicago, Illinois","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054253771","display_name":"Sridhar Mani","orcid":"https://orcid.org/0000-0003-4132-6157","observed_orcids":["https://orcid.org/0000-0003-4132-6157"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Mani","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068268371","display_name":"Mark J. Ratain","orcid":"https://orcid.org/0000-0002-0938-4392","observed_orcids":["https://orcid.org/0000-0002-0938-4392"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Ratain","raw_affiliation_strings":["Cancer Research Center, Chicago, Illinois","Committee on Clinical Pharmacology, Chicago, Illinois","Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Chicago, Illinois","institution_ids":[]},{"raw_affiliation_string":"Committee on Clinical Pharmacology, Chicago, Illinois","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109997055"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210091812"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.4098,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61036423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"3","first_page":"528","last_page":"532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raltitrexed","display_name":"raltitrexed","score":1.0},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/thymidylate-synthase-inhibitors","display_name":"thymidylate synthase inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.6380000114440918},{"id":"https://openalex.org/keywords/refractory-cancer","display_name":"refractory cancer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9357630014419556},{"id":"https://openalex.org/C2779268555","wikidata":"https://www.wikidata.org/wiki/Q15304877","display_name":"Raltitrexed","level":5,"score":0.9014267921447754},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6524577140808105},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6321686506271362},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5697925686836243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5218302607536316},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4705268144607544},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36576923727989197},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3470243513584137},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.2624862790107727},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.15476417541503906}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990801%2986%3A3%3C528%3A%3AAID-CNCR23%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.3.co;2-i","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.3.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.3.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:10430263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10430263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","doi":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<528::aid-cncr23>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990801%2986%3A3%3C528%3A%3AAID-CNCR23%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G88379001","display_name":"Phase I Clinical Trials of Anti-Cancer Agents","funder_award_id":"U01CA069852","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000865577","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA014599","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009215324.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W131577465","https://openalex.org/W1842046266","https://openalex.org/W1873275656","https://openalex.org/W1960713055","https://openalex.org/W2024756387","https://openalex.org/W2025488028","https://openalex.org/W2026018236","https://openalex.org/W2085643819","https://openalex.org/W2106482770","https://openalex.org/W2110519215","https://openalex.org/W2119270435","https://openalex.org/W2131232623","https://openalex.org/W2155946383","https://openalex.org/W2168880312","https://openalex.org/W2320370693","https://openalex.org/W2618123661","https://openalex.org/W4255762755","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1897113776","https://openalex.org/W2131280104","https://openalex.org/W2055406451","https://openalex.org/W2000412644","https://openalex.org/W2002014955","https://openalex.org/W1983449890","https://openalex.org/W1775148994","https://openalex.org/W2135791859","https://openalex.org/W2068481523","https://openalex.org/W2053900550"],"abstract_inverted_index":{"BACKGROUND:":[0],"Raltitrexed":[1,165],"is":[2,32,265],"a":[3,29,41,66,89,123,152,191,198,221],"novel":[4],"thymidylate":[5],"synthase":[6],"inhibitor":[7],"with":[8,83,115,226,235],"single":[9,30,254],"agent":[10,31,255],"activity":[11],"in":[12,53,162,168,207,249],"colorectal,":[13],"nonsmall":[14],"cell":[15],"lung,":[16],"and":[17,65,68,134,231,233,244],"breast":[18],"carcinomas.":[19],"The":[20,239],"recommended":[21,178],"Phase":[22,47,179,256,259],"II":[23,180,257,260],"dose":[24,153,181,193,199],"of":[25,44,50,74,79,86,98,126,138,158,170,182,194,200,209,228,262],"raltitrexed":[26,87,192,243],"administered":[27,100,248],"as":[28,88,108],"3":[33,36,102,128,183,201],"mg/m2":[34,97,175],"every":[35],"weeks.":[37],"Paclitaxel":[38],"also":[39],"has":[40],"broad":[42],"spectrum":[43],"activity.":[45],"A":[46,156],"I":[48],"study":[49],"both":[51],"agents":[52],"combination":[54,250,264],"therapy":[55],"was":[56,106,166,188,205,213],"conducted.":[57],"METHODS:":[58],"Eligible":[59],"patients":[60,80,160,219],"had":[61],"refractory":[62],"solid":[63],"tumors":[64],"Cancer":[67],"Leukemia":[69],"Group":[70],"B":[71],"performance":[72],"status":[73],"0":[75],"to":[76,140,142,176],"2.":[77],"Cohorts":[78],"were":[81],"treated":[82],"escalating":[84],"doses":[85],"15-minute":[90],"intravenous":[91],"infusion":[92],"immediately":[93],"followed":[94],"by":[95],"175":[96],"paclitaxel":[99,245],"over":[101],"hours.":[103],"Dose-limiting":[104,185],"toxicity":[105,125,186],"defined":[107],"World":[109],"Health":[110],"Organization":[111],"Grade":[112,117,127,143],"4":[113,118],"neutropenia":[114,204],"fever,":[116],"thrombocytopenia":[119],"requiring":[120],"platelet":[121],"transfusion,":[122],"nonhematologic":[124],"or":[129,136,145],"higher":[130],"(excluding":[131],"nausea,":[132],"emesis,":[133],"alopecia),":[135],"failure":[137],"toxicities":[139],"recover":[141],"1":[144],"lower":[146],"within":[147],"21":[148],"days":[149],"after":[150],"causing":[151],"delay.":[154],"RESULTS:":[155],"total":[157],"33":[159],"enrolled":[161],"the":[163,177,214,229],"study.":[164],"escalated":[167],"increments":[169],"0.5":[171,174],"mg/m2,":[172,202],"from":[173],"mg/m2.":[184,196],"first":[187],"observed":[189,206],"at":[190,251],"2":[195,208],"At":[197],"dose-limiting":[203,216],"12":[210],"patients.":[211],"Diarrhea":[212],"other":[215],"toxicity.":[217],"Two":[218],"achieved":[220],"partial":[222],"response":[223],"(one":[224],"patient":[225],"carcinoma":[227],"head":[230],"neck":[232],"another":[234],"gallbladder":[236],"carcinoma).":[237],"CONCLUSIONS:":[238],"authors":[240],"conclude":[241],"that":[242],"may":[246],"be":[247],"their":[252],"respective":[253],"doses.":[258],"testing":[261],"this":[263],"indicated.":[266]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}