{"id":"https://openalex.org/W2009207148","doi":"https://doi.org/10.1291/hypres.17.87","title":"Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.","display_name":"Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2009207148","doi":"https://doi.org/10.1291/hypres.17.87","mag":"2009207148"},"language":"en","primary_location":{"id":"doi:10.1291/hypres.17.87","doi":"https://doi.org/10.1291/hypres.17.87","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.17.87","pdf_url":"https://www.jstage.jst.go.jp/article/hypres1992/17/2/17_2_87/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/hypres1992/17/2/17_2_87/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111367946","display_name":"Tadashi Inagami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tadashi Inagami","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University, School of Medicine","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085201867","display_name":"Yutaka Kitami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yutaka Kitami","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University, School of Medicine","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":5.7332,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.96430947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"87","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-receptor","display_name":"angiotensin II receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/phospholipase-c-signaling","display_name":"phospholipase C signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.953000009059906},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7489957809448242},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6574589014053345},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.6566066741943359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6464471220970154},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5569263100624084},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5164492130279541},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5154002904891968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5103883147239685},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.473757803440094},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39759665727615356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30583518743515015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20230141282081604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1291/hypres.17.87","doi":"https://doi.org/10.1291/hypres.17.87","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.17.87","pdf_url":"https://www.jstage.jst.go.jp/article/hypres1992/17/2/17_2_87/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1291/hypres.17.87","doi":"https://doi.org/10.1291/hypres.17.87","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.17.87","pdf_url":"https://www.jstage.jst.go.jp/article/hypres1992/17/2/17_2_87/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009207148.pdf","grobid_xml":"https://content.openalex.org/works/W2009207148.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1519825607","https://openalex.org/W1527240164","https://openalex.org/W1558224624","https://openalex.org/W1571003781","https://openalex.org/W1590372519","https://openalex.org/W1591510379","https://openalex.org/W1762236896","https://openalex.org/W1951537243","https://openalex.org/W1965570459","https://openalex.org/W1966092598","https://openalex.org/W1967561584","https://openalex.org/W1968874083","https://openalex.org/W1972301110","https://openalex.org/W1972920641","https://openalex.org/W1973362284","https://openalex.org/W1973662430","https://openalex.org/W1980258438","https://openalex.org/W1982200616","https://openalex.org/W1989204474","https://openalex.org/W1994116664","https://openalex.org/W1998976251","https://openalex.org/W1999156171","https://openalex.org/W2001477260","https://openalex.org/W2004327312","https://openalex.org/W2006294557","https://openalex.org/W2012207889","https://openalex.org/W2013489999","https://openalex.org/W2016342526","https://openalex.org/W2017800047","https://openalex.org/W2018541556","https://openalex.org/W2019047292","https://openalex.org/W2019353944","https://openalex.org/W2024919307","https://openalex.org/W2030832817","https://openalex.org/W2043623738","https://openalex.org/W2044799513","https://openalex.org/W2047336009","https://openalex.org/W2055932468","https://openalex.org/W2058650000","https://openalex.org/W2059179835","https://openalex.org/W2061351672","https://openalex.org/W2062228467","https://openalex.org/W2064098156","https://openalex.org/W2065003109","https://openalex.org/W2065236378","https://openalex.org/W2068571699","https://openalex.org/W2071426141","https://openalex.org/W2080217330","https://openalex.org/W2084339368","https://openalex.org/W2086870938","https://openalex.org/W2087023069","https://openalex.org/W2089910480","https://openalex.org/W2092171289","https://openalex.org/W2093502242","https://openalex.org/W2095364526","https://openalex.org/W2098976457","https://openalex.org/W2145879452","https://openalex.org/W2167756266","https://openalex.org/W2215676446","https://openalex.org/W2257844669","https://openalex.org/W2396089981","https://openalex.org/W2413973431","https://openalex.org/W2416696183","https://openalex.org/W2417520021","https://openalex.org/W2428322574","https://openalex.org/W2460412969","https://openalex.org/W2463637676"],"related_works":["https://openalex.org/W2164081909","https://openalex.org/W2422214038","https://openalex.org/W2020916096","https://openalex.org/W2074645772","https://openalex.org/W2473676723","https://openalex.org/W2464985567","https://openalex.org/W2043953269","https://openalex.org/W1527240164","https://openalex.org/W2405940724","https://openalex.org/W2409682533"],"abstract_inverted_index":{"Angiotensin":[0,197],"II":[1,78,198],"receptors":[2],"are":[3,191],"diverse":[4],"and":[5,13,26,38,52,102,150,176,181],"mediate":[6],"complex":[7],"signaling":[8],"mechanisms.":[9],"Their":[10,188],"isoforms":[11],"AT1":[12,18,63,67,180,204],"AT2":[14,95,134,182],"have":[15,154],"been":[16,65,155],"cloned.":[17],"consists":[19],"of":[20,62,72,85,90,118,121,185,202],"two":[21,207],"closely":[22],"related":[23],"subtypes,":[24],"AT1A":[25,30],"AT1B,":[27],"in":[28,34,46,116,157,193],"rodents.":[29],"is":[31,43],"expressed":[32,156],"preferentially":[33],"the":[35,50,70,81,119,126,200,203],"kidney,":[36],"liver":[37],"cardiovascular":[39],"tissues,":[40],"whereas,":[41,210],"AT1B":[42],"found":[44,136],"mainly":[45],"endocrine":[47],"tissues":[48,101],"like":[49],"adrenal":[51],"pituitary":[53],"glands.":[54],"In":[55],"higher":[56],"mammals":[57],"only":[58],"a":[59,107,111,143,194],"single":[60,195],"isoform":[61],"has":[64,106],"reported.":[66],"accounts":[68],"for":[69,171,177],"majority":[71],"actions":[73],"traditionally":[74],"ascribed":[75],"to":[76,125,137,160],"angiotensin":[77],"that":[79],"include":[80],"Gq-protein":[82],"coupled":[83],"activation":[84],"phospholipase":[86],"C,":[87],"Gi-coupled":[88],"opening":[89],"an":[91],"L-type":[92],"calcium":[93],"channel.":[94],"was":[96,135],"cloned":[97,148],"recently":[98],"from":[99],"rat":[100],"cell":[103],"lines.":[104],"It":[105],"structure":[108],"compatible":[109],"with":[110,173],"seven":[112],"transmembrane":[113],"domain":[114],"receptor":[115],"spite":[117],"lack":[120],"internalization":[122],"or":[123],"shift":[124],"low":[127],"affinity":[128],"state":[129],"by":[130,142,206],"stable":[131],"GTP":[132],"analogs.":[133],"inhibit":[138],"certain":[139],"phosphotyrosine":[140],"phosphatase(s)":[141],"pertussis":[144],"toxin-sensitive":[145],"mechanism.":[146],"These":[147],"cDNAs":[149,153],"their":[151],"mutated":[152],"mammalian":[158],"cells":[159],"identify":[161],"various":[162,174],"functional":[163],"domains":[164,170],"such":[165],"as":[166],"ligand":[167],"binding":[168],"sites,":[169],"interaction":[172],"G-proteins,":[175],"desensitization.":[178],"Both":[179],"genes":[183],"consist":[184],"3-5":[186],"exons.":[187],"coding":[189],"regions":[190],"contained":[192],"exon.":[196],"down-regulates":[199],"expression":[201],"gene":[205],"different":[208],"mechanisms,":[209],"glucocorticoids":[211],"up-regulates":[212],"it.":[213],"(Hypertens":[214],"Res":[215],"1994;":[216],"17:87-97)":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
