{"id":"https://openalex.org/W2009193349","doi":"https://doi.org/10.1523/jneurosci.4327-07.2008","title":"ConstitutiveEGFRSignaling in Oligodendrocyte Progenitors Leads to Diffuse Hyperplasia in Postnatal White Matter","display_name":"ConstitutiveEGFRSignaling in Oligodendrocyte Progenitors Leads to Diffuse Hyperplasia in Postnatal White Matter","publication_year":2008,"publication_date":"2008-01-23","ids":{"openalex":"https://openalex.org/W2009193349","doi":"https://doi.org/10.1523/jneurosci.4327-07.2008","mag":"2009193349","pmid":"https://pubmed.ncbi.nlm.nih.gov/18216199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2711628"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4327-07.2008","doi":"https://doi.org/10.1523/jneurosci.4327-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4327-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/4/914.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/28/4/914.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083992553","display_name":"Sanja Ivkovi\u0107","orcid":"https://orcid.org/0000-0002-7977-3166","observed_orcids":["https://orcid.org/0000-0002-7977-3166"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanja Ivkovic","raw_affiliation_strings":["Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA. si2117@columbia.edu","Department of Pathology and The Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA. si2117@columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pathology and The Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Canoll","raw_affiliation_strings":["Department of Pathology , Columbia University , 630 West 168th Street , New York , NY 10032 ","Department of Pathology and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Columbia University , 630 West 168th Street , New York , NY 10032 ","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pathology and the","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011457832","display_name":"James E. Goldman","orcid":"https://orcid.org/0000-0003-2135-8936","observed_orcids":["https://orcid.org/0000-0003-2135-8936"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Goldman","raw_affiliation_strings":["Center for Neurobiology and Behavior, Columbia University, New York, New York 10032","Department of Pathology and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pathology and the","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1828,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.86147757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"4","first_page":"914","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/oligodendrocyte-progenitors","display_name":"oligodendrocyte progenitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.5289999842643738},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ng2","display_name":"NG2","score":0.5450000166893005},{"id":"https://openalex.org/keywords/olig2","display_name":"Olig2","score":0.921999990940094},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7458816766738892},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7257921695709229},{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.7073197960853577},{"id":"https://openalex.org/C48261664","wikidata":"https://www.wikidata.org/wiki/Q14908218","display_name":"Gliogenesis","level":4,"score":0.6848309636116028},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5927837491035461},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.5878881216049194},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5022244453430176},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.4697100520133972},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4502630829811096},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3705374300479889},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21436423063278198},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2085273563861847},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10909038782119751},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.08133721351623535},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.07173553109169006}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009413","descriptor_name":"Nerve Fibers, Myelinated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009413","descriptor_name":"Nerve Fibers, Myelinated","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.4327-07.2008","doi":"https://doi.org/10.1523/jneurosci.4327-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4327-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/4/914.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2711628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2711628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:18216199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18216199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4327-07.2008","doi":"https://doi.org/10.1523/jneurosci.4327-07.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4327-07.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/4/914.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3969262834","display_name":"Simple Vertebrate and Invertebrate Systems","funder_award_id":"T32NS007062","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4798758820","display_name":null,"funder_award_id":"NS07062-28","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5911794678","display_name":"The Role of Eph-ephrin Interactions in Glioma Migration","funder_award_id":"K08NS045070","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6691897499","display_name":"Cellular and Biochemical Studies of CNS Glia","funder_award_id":"R01NS017125","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8322305926","display_name":null,"funder_award_id":"MH157174-28","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009193349.pdf","grobid_xml":"https://content.openalex.org/works/W2009193349.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W4414310","https://openalex.org/W1487914405","https://openalex.org/W1572000449","https://openalex.org/W1657021256","https://openalex.org/W1820190775","https://openalex.org/W1970610673","https://openalex.org/W1974546646","https://openalex.org/W1980607613","https://openalex.org/W1983350374","https://openalex.org/W1996245847","https://openalex.org/W1996410410","https://openalex.org/W1996995343","https://openalex.org/W1997945370","https://openalex.org/W2009165056","https://openalex.org/W2013032157","https://openalex.org/W2022380830","https://openalex.org/W2028415754","https://openalex.org/W2035033765","https://openalex.org/W2044142173","https://openalex.org/W2055561480","https://openalex.org/W2059877177","https://openalex.org/W2060145322","https://openalex.org/W2060209241","https://openalex.org/W2067376187","https://openalex.org/W2073437876","https://openalex.org/W2076682664","https://openalex.org/W2095065858","https://openalex.org/W2101506365","https://openalex.org/W2112050795","https://openalex.org/W2119797078","https://openalex.org/W2123303833","https://openalex.org/W2123667883","https://openalex.org/W2124625215","https://openalex.org/W2131192891","https://openalex.org/W2139646621","https://openalex.org/W2150069346","https://openalex.org/W2155639900","https://openalex.org/W2159178451","https://openalex.org/W2160105055","https://openalex.org/W2161155632","https://openalex.org/W2164789880","https://openalex.org/W2183343968","https://openalex.org/W4211075026"],"related_works":["https://openalex.org/W1976116467","https://openalex.org/W2164582252","https://openalex.org/W2565225510","https://openalex.org/W2060209241","https://openalex.org/W2035033765","https://openalex.org/W2076682664","https://openalex.org/W4321378847","https://openalex.org/W1983350374","https://openalex.org/W60455745","https://openalex.org/W2607353839"],"abstract_inverted_index":{"Gliogenesis":[0],"requires":[1,197],"the":[2,14,56,63,69,81,87,104,118],"careful":[3],"orchestration":[4],"of":[5,10,30,55,65,89,100,120,132,158,164,180],"migration,":[6],"differentiation,":[7,195],"and":[8,61,77,84,111,140],"proliferation":[9],"progenitors.":[11,35,148],"Signaling":[12],"through":[13],"epidermal":[15],"growth":[16],"factor":[17],"receptor":[18],"(EGFR)":[19],"has":[20],"been":[21],"implicated":[22],"in":[23,27,46,59,108,117,168,183],"regulating":[24],"these":[25,66,101],"processes":[26],"a":[28,114,126,143,162],"variety":[29],"cell":[31,106],"types,":[32],"including":[33],"neural":[34],"By":[36],"retroviral":[37],"infection,":[38,91],"we":[39],"constitutively":[40],"expressed":[41],"an":[42],"EGFR-GFP":[43],"fusion":[44],"protein":[45],"white":[47,109],"matter":[48,110],"glial":[49,121,181,194],"progenitors":[50,182],"at":[51],"postnatal":[52],"day":[53],"3":[54],"rat":[57],"forebrain":[58],"vivo":[60],"analyzed":[62],"development":[64],"cells":[67,74,102],"over":[68],"subsequent":[70],"15":[71],"weeks.":[72],"EGFR-GFP+":[73],"remained":[75],"proliferative":[76],"migratory,":[78],"gradually":[79],"populating":[80],"brains":[82],"ipsilateral":[83],"contralateral":[85],"to":[86,113,125,146,175],"side":[88],"viral":[90],"but":[92,196],"never":[93],"differentiated":[94],"into":[95],"mature":[96],"glia.":[97],"The":[98,129],"accumulation":[99,157],"doubled":[103],"total":[105],"density":[107],"led":[112],"10-fold":[115],"increase":[116],"abundance":[119],"progenitors,":[122],"giving":[123],"rise":[124],"progenitor":[127],"\"hyperplasia.\"":[128],"marker":[130],"profile":[131],"infected":[133],"cells,":[134],"NG2+,":[135],"olig2+,":[136],"PDGFR-alpha+,":[137],"nestin+,":[138],"GFAP-,":[139],"CC1-,":[141],"indicated":[142],"close":[144],"resemblance":[145],"oligodendrocyte":[147],"Positive":[149],"immunostaining":[150,179],"for":[151],"phosphorylated":[152],"EGFR":[153,178,190],"colocalized":[154],"with":[155],"punctate":[156],"EGFR-GFP,":[159],"indicating":[160],"that":[161,188],"subset":[163],"receptors":[165],"was":[166,173],"engaged":[167],"active":[169],"signaling.":[170],"Furthermore,":[171],"EGF":[172],"required":[174],"observe":[176],"phospho-tyrosine":[177],"culture.":[184],"These":[185],"observations":[186],"suggest":[187],"constitutive":[189],"expression":[191],"can":[192],"inhibit":[193],"ligand":[198],"as":[199],"well.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}