{"id":"https://openalex.org/W2009179732","doi":"https://doi.org/10.1016/j.fct.2007.10.006","title":"Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG","display_name":"Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG","publication_year":2007,"publication_date":"2007-10-18","ids":{"openalex":"https://openalex.org/W2009179732","doi":"https://doi.org/10.1016/j.fct.2007.10.006","mag":"2009179732","pmid":"https://pubmed.ncbi.nlm.nih.gov/18082923"},"language":"en","primary_location":{"id":"doi:10.1016/j.fct.2007.10.006","doi":"https://doi.org/10.1016/j.fct.2007.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fct.2007.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072092583","display_name":"Hye\u2010Kyung Na","orcid":"https://orcid.org/0000-0003-0460-2810","observed_orcids":["https://orcid.org/0000-0003-0460-2810"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Kyung Na","raw_affiliation_strings":["National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061532156","display_name":"Young\u2010Joon Surh","orcid":"https://orcid.org/0000-0001-8310-1795","observed_orcids":["https://orcid.org/0000-0001-8310-1795"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Joon Surh","raw_affiliation_strings":["National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061532156"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":1.1801,"has_fulltext":false,"cited_by_count":496,"citation_normalized_percentile":{"value":0.75743349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"46","issue":"4","first_page":"1271","last_page":"1278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8360000252723694},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9490000009536743},{"id":"https://openalex.org/keywords/green-tea-polyphenols","display_name":"green tea polyphenols","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6420000195503235},{"id":"https://openalex.org/keywords/detoxification-enzymes","display_name":"detoxification enzymes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/phase-ii-enzymes","display_name":"phase II enzymes","score":0.6499999761581421},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.902999997138977},{"id":"https://openalex.org/keywords/electrophiles","display_name":"electrophiles","score":0.7559999823570251},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/redox-sensitive-transcription-factors","display_name":"redox-sensitive transcription factors","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2911092814","wikidata":"https://www.wikidata.org/wiki/Q5090611","display_name":"Chemoprotective","level":3,"score":0.8210061192512512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6357007026672363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.57530677318573},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5749278664588928},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5313825011253357},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.507049560546875},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4739116430282593},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.46525293588638306},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34268516302108765},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3317820429801941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2977813482284546},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.22242078185081482}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013662","descriptor_name":"Tea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.fct.2007.10.006","doi":"https://doi.org/10.1016/j.fct.2007.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fct.2007.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:18082923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18082923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/172706","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/172706","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article; Proceedings Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W885975945","https://openalex.org/W1607772536","https://openalex.org/W1644516630","https://openalex.org/W1924592317","https://openalex.org/W1934800228","https://openalex.org/W1973907050","https://openalex.org/W1987388371","https://openalex.org/W1991631628","https://openalex.org/W1993994156","https://openalex.org/W1997539317","https://openalex.org/W1999972823","https://openalex.org/W2002154317","https://openalex.org/W2002205161","https://openalex.org/W2003067838","https://openalex.org/W2004288386","https://openalex.org/W2011690681","https://openalex.org/W2012908941","https://openalex.org/W2018264979","https://openalex.org/W2020703172","https://openalex.org/W2024445540","https://openalex.org/W2030364043","https://openalex.org/W2030867249","https://openalex.org/W2031377838","https://openalex.org/W2033802853","https://openalex.org/W2036809593","https://openalex.org/W2044911368","https://openalex.org/W2046074852","https://openalex.org/W2049413530","https://openalex.org/W2049641944","https://openalex.org/W2056916650","https://openalex.org/W2066241876","https://openalex.org/W2068642882","https://openalex.org/W2075495668","https://openalex.org/W2076659194","https://openalex.org/W2076935230","https://openalex.org/W2078723138","https://openalex.org/W2080506742","https://openalex.org/W2085543440","https://openalex.org/W2086300030","https://openalex.org/W2092733898","https://openalex.org/W2095046939","https://openalex.org/W2097098555","https://openalex.org/W2097634036","https://openalex.org/W2098782131","https://openalex.org/W2101356736","https://openalex.org/W2102022034","https://openalex.org/W2106239208","https://openalex.org/W2107673483","https://openalex.org/W2108651337","https://openalex.org/W2113971187","https://openalex.org/W2120331262","https://openalex.org/W2124122523","https://openalex.org/W2124524961","https://openalex.org/W2124743242","https://openalex.org/W2127390105","https://openalex.org/W2130029858","https://openalex.org/W2133930222","https://openalex.org/W2135655204","https://openalex.org/W2136865018","https://openalex.org/W2139476788","https://openalex.org/W2140573009","https://openalex.org/W2142749576","https://openalex.org/W2156060653","https://openalex.org/W2156720978","https://openalex.org/W2157908307","https://openalex.org/W2161982997","https://openalex.org/W2165643859","https://openalex.org/W2312461597","https://openalex.org/W2405508606","https://openalex.org/W2414476565","https://openalex.org/W4322715279","https://openalex.org/W6636292550","https://openalex.org/W6636725678","https://openalex.org/W6674561587","https://openalex.org/W6680399191","https://openalex.org/W6684307381"],"related_works":["https://openalex.org/W2401697499","https://openalex.org/W2029102160","https://openalex.org/W2008684113","https://openalex.org/W2093968916","https://openalex.org/W4283119626","https://openalex.org/W2752264956","https://openalex.org/W3126909677","https://openalex.org/W2140172451","https://openalex.org/W2147463495","https://openalex.org/W1972217236"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}