{"id":"https://openalex.org/W2009178147","doi":"https://doi.org/10.1371/journal.ppat.1004733","title":"The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family","display_name":"The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family","publication_year":2015,"publication_date":"2015-03-23","ids":{"openalex":"https://openalex.org/W2009178147","doi":"https://doi.org/10.1371/journal.ppat.1004733","mag":"2009178147","pmid":"https://pubmed.ncbi.nlm.nih.gov/25799064","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4370873"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1004733","doi":"https://doi.org/10.1371/journal.ppat.1004733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004733","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004733&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004733&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001524461","display_name":"Lonneke van der Linden","orcid":"https://orcid.org/0000-0003-3273-6728","observed_orcids":["https://orcid.org/0000-0003-3273-6728"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","NL"],"is_corresponding":true,"raw_author_name":"Lonneke van der Linden","raw_affiliation_strings":["Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I2802934949","https://openalex.org/I4210109357","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009375922","display_name":"Laia Vives-Adri\u00e1n","orcid":"https://orcid.org/0000-0003-3479-5908","observed_orcids":["https://orcid.org/0000-0003-3479-5908"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210166526","display_name":"Institut de Biologia Molecular de Barcelona","ror":"https://ror.org/05t8khn72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210166526"]},{"id":"https://openalex.org/I4405281164","display_name":"Parc Cient\u00edfic de Barcelona","ror":"https://ror.org/03z3b5m17","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405281164","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Laia Vives-Adri\u00e1n","raw_affiliation_strings":["Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210166526","https://openalex.org/I4405281164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071436463","display_name":"Barbara Selisko","orcid":"https://orcid.org/0000-0001-7135-4357","observed_orcids":["https://orcid.org/0000-0001-7135-4357"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Barbara Selisko","raw_affiliation_strings":["AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025419024","display_name":"Cristina Ferrer\u2010Orta","orcid":"https://orcid.org/0000-0002-1072-8463","observed_orcids":["https://orcid.org/0000-0002-1072-8463"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210166526","display_name":"Institut de Biologia Molecular de Barcelona","ror":"https://ror.org/05t8khn72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210166526"]},{"id":"https://openalex.org/I4405281164","display_name":"Parc Cient\u00edfic de Barcelona","ror":"https://ror.org/03z3b5m17","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405281164","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Cristina Ferrer-Orta","raw_affiliation_strings":["Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210166526","https://openalex.org/I4405281164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043316737","display_name":"Xinran Liu","orcid":"https://orcid.org/0000-0002-3732-6632","observed_orcids":["https://orcid.org/0000-0002-3732-6632"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xinran Liu","raw_affiliation_strings":["Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077345144","display_name":"Kjerstin H. W. Lanke","orcid":"https://orcid.org/0000-0001-8970-8432","observed_orcids":["https://orcid.org/0000-0001-8970-8432"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Kjerstin Lanke","raw_affiliation_strings":["Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071095963","display_name":"Rachel Ulferts","orcid":"https://orcid.org/0000-0002-4810-9115","observed_orcids":["https://orcid.org/0000-0002-4810-9115"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rachel Ulferts","raw_affiliation_strings":["Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I2802934949","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103540503","display_name":"Armando M. De Palma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Armando M. De Palma","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077816435","display_name":"Federica Tanchis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Federica Tanchis","raw_affiliation_strings":["Abteilung Pharmazeutische Chemie, Institut f\u00fcr Pharmazie, Universit\u00e4t Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Pharmazeutische Chemie, Institut f\u00fcr Pharmazie, Universit\u00e4t Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077739801","display_name":"Nesya Goris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nesya Goris","raw_affiliation_strings":["Okapi Sciences NV, Heverlee, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okapi Sciences NV, Heverlee, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102826960","display_name":"David J. Lefebvre","orcid":"https://orcid.org/0000-0002-3012-1546","observed_orcids":["https://orcid.org/0000-0002-3012-1546"]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"David Lefebvre","raw_affiliation_strings":["Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082484461","display_name":"Kris De Clercq","orcid":"https://orcid.org/0000-0002-2928-3521","observed_orcids":["https://orcid.org/0000-0002-2928-3521"]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Kris De Clercq","raw_affiliation_strings":["Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA, Veterinary and Agrochemical Research Centre, Brussels, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036860979","display_name":"Pieter Leyssen","orcid":"https://orcid.org/0000-0002-7537-1688","observed_orcids":["https://orcid.org/0000-0002-7537-1688"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Pieter Leyssen","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C\u00e9line Lacroix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"C\u00e9line Lacroix","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010598506","display_name":"Gerhard P\u00fcrstinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Gerhard P\u00fcrstinger","raw_affiliation_strings":["Abteilung Pharmazeutische Chemie, Institut f\u00fcr Pharmazie, Universit\u00e4t Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Pharmazeutische Chemie, Institut f\u00fcr Pharmazie, Universit\u00e4t Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090442657","display_name":"Bruno Coutard","orcid":"https://orcid.org/0000-0002-2859-7123","observed_orcids":["https://orcid.org/0000-0002-2859-7123"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bruno Coutard","raw_affiliation_strings":["AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039783946","display_name":"Bruno Canard","orcid":"https://orcid.org/0000-0003-4924-1991","observed_orcids":["https://orcid.org/0000-0003-4924-1991"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bruno Canard","raw_affiliation_strings":["AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFMB UMR 7257, Aix-Marseille Universit\u00e9 & CNRS, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017875151","display_name":"David D. Boehr","orcid":"https://orcid.org/0000-0002-8886-2873","observed_orcids":["https://orcid.org/0000-0002-8886-2873"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David D. Boehr","raw_affiliation_strings":["Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037188019","display_name":"Jamie J. Arnold","orcid":"https://orcid.org/0000-0002-2345-9776","observed_orcids":["https://orcid.org/0000-0002-2345-9776"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jamie J. Arnold","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021526153","display_name":"Craig E. Cameron","orcid":"https://orcid.org/0000-0002-7564-5642","observed_orcids":["https://orcid.org/0000-0002-7564-5642"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig E. Cameron","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052859920","display_name":"N\u00faria Verdaguer","orcid":"https://orcid.org/0000-0001-8826-7129","observed_orcids":["https://orcid.org/0000-0001-8826-7129"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210166526","display_name":"Institut de Biologia Molecular de Barcelona","ror":"https://ror.org/05t8khn72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210166526"]},{"id":"https://openalex.org/I4405281164","display_name":"Parc Cient\u00edfic de Barcelona","ror":"https://ror.org/03z3b5m17","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405281164","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Nuria Verdaguer","raw_affiliation_strings":["Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologia Molecular de Barcelona (CSIC), Parc Cient\u00edfic de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210166526","https://openalex.org/I4405281164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040714564","display_name":"Frank J. M. van Kuppeveld","orcid":"https://orcid.org/0000-0001-5800-749X","observed_orcids":["https://orcid.org/0000-0001-5800-749X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Frank J. M. van Kuppeveld","raw_affiliation_strings":["Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I2802934949","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210109357"]},{"raw_affiliation_string":"Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5001524461","https://openalex.org/A5009375922","https://openalex.org/A5010598506","https://openalex.org/A5017875151","https://openalex.org/A5021526153","https://openalex.org/A5025419024","https://openalex.org/A5036860979","https://openalex.org/A5037188019","https://openalex.org/A5039783946","https://openalex.org/A5040714564","https://openalex.org/A5043316737","https://openalex.org/A5052859920","https://openalex.org/A5071095963","https://openalex.org/A5071436463","https://openalex.org/A5077345144","https://openalex.org/A5077739801","https://openalex.org/A5077816435","https://openalex.org/A5082484461","https://openalex.org/A5089010495","https://openalex.org/A5090442657","https://openalex.org/A5102826960","https://openalex.org/A5103540503"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I130769515","https://openalex.org/I134820265","https://openalex.org/I190249584","https://openalex.org/I193662353","https://openalex.org/I21491767","https://openalex.org/I24156275","https://openalex.org/I2802934949","https://openalex.org/I4210108698","https://openalex.org/I4210109357","https://openalex.org/I4210146787","https://openalex.org/I4210166526","https://openalex.org/I4405281164","https://openalex.org/I99464096"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":6.4584,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.97270639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"3","first_page":"e1004733","last_page":"e1004733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.4918999969959259,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.968999981880188},{"id":"https://openalex.org/keywords/non-nucleoside-inhibitors","display_name":"non-nucleoside inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/enterovirus","display_name":"enterovirus","score":0.6729999780654907},{"id":"https://openalex.org/keywords/coxsackievirus-b3","display_name":"coxsackievirus B3","score":0.9599999785423279},{"id":"https://openalex.org/keywords/poliovirus","display_name":"poliovirus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/encephalomyocarditis-virus","display_name":"encephalomyocarditis virus","score":0.8299999833106995},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.7009999752044678},{"id":"https://openalex.org/keywords/broad-spectrum-antiviral-drugs","display_name":"broad-spectrum antiviral drugs","score":0.7889999747276306},{"id":"https://openalex.org/keywords/rna-binding-pocket","display_name":"RNA binding pocket","score":0.5960000157356262},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.4580000042915344},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.6331918835639954},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6284486055374146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5733805298805237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5705940127372742},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.5541792511940002},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5526321530342102},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.4996457099914551},{"id":"https://openalex.org/C2779120600","wikidata":"https://www.wikidata.org/wiki/Q1138287","display_name":"Coxsackievirus","level":4,"score":0.4981093406677246},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.42470672726631165},{"id":"https://openalex.org/C2778009244","wikidata":"https://www.wikidata.org/wiki/Q936600","display_name":"Picornavirus","level":4,"score":0.4103606939315796},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3300086259841919},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2097349464893341},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16784271597862244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10443806648254395}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017943","descriptor_name":"Cardiovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D029822","descriptor_name":"Enterovirus B, Human","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":15,"locations":[{"id":"doi:10.1371/journal.ppat.1004733","doi":"https://doi.org/10.1371/journal.ppat.1004733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004733","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004733&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3350448","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4370873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25799064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25799064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4370873","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4370873/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:rn301668f","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/yjrb-2b19","pdf_url":"https://doi.org/10.17615/yjrb-2b19","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 11(3)","raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/492273","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/492273","pdf_url":"https://lirias.kuleuven.be/retrieve/2fef25c9-cf3e-40ce-b817-f02b7da9efd2","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, vol. 11 (3), Art.No. ARTN e1004733","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/154135","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/154135","pdf_url":"http://hdl.handle.net/2066/154135","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Pathogens, 11, e1004733","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/504802cb-d701-48cc-b82c-1dd327830574","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/the-rna-template-channel-of-the-rnadependent-rna-polymerase-as-a-target-for-development-of-antiviral-therapy-of-multiple-genera-within-a-virus-family(504802cb-d701-48cc-b82c-1dd327830574).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS pathogens, 11(3). Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/124125","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/124125","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:184861f7dc7545d98c08e695d7ff897c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/184861f7dc7545d98c08e695d7ff897c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 11, Iss 3, p e1004733 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1351854","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_The_RNA_Template_Channel_of_the_RNA_Dependent_RNA_Polymerase_as_a_Target_for_Development_of_Antiviral_Therapy_of_Multiple_Genera_within_a_Virus_Family_/1351854","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/873d207e-2e0e-4551-81aa-643a0aebdbd6","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/173156790/The-rna-template-channel-of-the-rna-dependent-rna-polymerase-as-a-target-for-development-of-antiviral-therapy-of-multipl.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/154135","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/154135","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Pathogens, 11, 3, pp. e1004733","raw_type":"Article / Letter to editor"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/330813","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/330813","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 11(3). Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.17615/yjrb-2b19","doi":"https://doi.org/10.17615/yjrb-2b19","is_oa":true,"landing_page_url":"https://doi.org/10.17615/yjrb-2b19","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1004733","doi":"https://doi.org/10.1371/journal.ppat.1004733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004733","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004733&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2484445916","display_name":"Watching conformational rearrangements in picornavirus replication proteins","funder_award_id":"R01AI104878","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2503715536","display_name":"European Virus Archive","funder_award_id":"228292","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4512999086","display_name":"Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses","funder_award_id":"260644","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320321013","display_name":"Radboud Universiteit","ror":"https://ror.org/016xsfp80"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009178147.pdf","grobid_xml":"https://content.openalex.org/works/W2009178147.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1484622499","https://openalex.org/W1495304774","https://openalex.org/W1511899369","https://openalex.org/W1512001995","https://openalex.org/W1519227646","https://openalex.org/W1560482078","https://openalex.org/W1967154222","https://openalex.org/W1967531524","https://openalex.org/W1969039527","https://openalex.org/W1970426642","https://openalex.org/W1994342014","https://openalex.org/W1998150898","https://openalex.org/W2004207626","https://openalex.org/W2006474721","https://openalex.org/W2023016206","https://openalex.org/W2024771806","https://openalex.org/W2030009404","https://openalex.org/W2030140637","https://openalex.org/W2033345469","https://openalex.org/W2038755950","https://openalex.org/W2038840577","https://openalex.org/W2052562665","https://openalex.org/W2061463182","https://openalex.org/W2063190922","https://openalex.org/W2063328126","https://openalex.org/W2063706063","https://openalex.org/W2076707886","https://openalex.org/W2078466653","https://openalex.org/W2079280284","https://openalex.org/W2079350158","https://openalex.org/W2080725002","https://openalex.org/W2080751230","https://openalex.org/W2101716268","https://openalex.org/W2103345897","https://openalex.org/W2103554874","https://openalex.org/W2110670926","https://openalex.org/W2111528675","https://openalex.org/W2113088776","https://openalex.org/W2118848130","https://openalex.org/W2124970098","https://openalex.org/W2126589642","https://openalex.org/W2126826536","https://openalex.org/W2131458435","https://openalex.org/W2131562775","https://openalex.org/W2143272638","https://openalex.org/W2143660875","https://openalex.org/W2144081223","https://openalex.org/W2144253080","https://openalex.org/W2145384203","https://openalex.org/W2152922959","https://openalex.org/W2153918414","https://openalex.org/W2159211495","https://openalex.org/W2162013089","https://openalex.org/W2167169475","https://openalex.org/W2171460607","https://openalex.org/W2181908191","https://openalex.org/W2256756668","https://openalex.org/W2595920264","https://openalex.org/W2786774014","https://openalex.org/W3217730596"],"related_works":["https://openalex.org/W7096787985","https://openalex.org/W3018369925","https://openalex.org/W1971382864","https://openalex.org/W4225383523","https://openalex.org/W2063190922","https://openalex.org/W1988135057","https://openalex.org/W3205533598","https://openalex.org/W2086279550","https://openalex.org/W2492181952","https://openalex.org/W2076707886"],"abstract_inverted_index":{"The":[0,26],"genus":[1,96],"Enterovirus":[2],"of":[3,71,142,175,179,197,204,225,229,247,263,276],"the":[4,61,98,139,156,170,180,187,191,198,201,205,212,223,230,238,243,248,261,274,280],"family":[5],"Picornaviridae":[6],"contains":[7],"many":[8],"important":[9,270],"human":[10],"pathogens":[11],"(e.g.,":[12],"poliovirus,":[13],"coxsackievirus,":[14],"rhinovirus,":[15],"and":[16,64,73,93,105,145,159,251],"enterovirus":[17],"71)":[18],"for":[19,35,193,260],"which":[20,55],"no":[21],"antiviral":[22,36],"drugs":[23],"are":[24,56,74],"available.":[25],"viral":[27],"RNA-dependent":[28],"RNA":[29,171,231,244],"polymerase":[30,131,250],"is":[31,215],"an":[32],"attractive":[33],"target":[34,52,192],"therapy.":[37],"Nucleoside-based":[38],"inhibitors":[39,50],"have":[40,66],"broad-spectrum":[41,89,264],"activity":[42,72,90,132,141,151],"but":[43,227],"often":[44],"exhibit":[45],"off-target":[46],"effects.":[47],"Most":[48],"non-nucleoside":[49],"(NNIs)":[51],"surface":[53],"cavities,":[54],"structurally":[57],"more":[58,68,75],"flexible":[59],"than":[60],"nucleotide-binding":[62],"pocket,":[63],"hence":[65],"a":[67,83,108,119,176,253],"narrow":[69],"spectrum":[70],"prone":[76],"to":[77,112,125,183,217],"resistance":[78,113,123,157],"development.":[79],"Here,":[80],"we":[81],"report":[82],"novel":[84],"NNI,":[85],"GPC-N114":[86,136,226],"(2,2'-[(4-chloro-1,2-phenylene)bis(oxy)]bis(5-nitro-benzonitrile))":[87],"with":[88,155,222],"against":[91,114,152],"enteroviruses":[92],"cardioviruses":[94],"(another":[95],"in":[97,127,164],"picornavirus":[99,249,277],"family).":[100],"Surprisingly,":[101],"coxsackievirus":[102],"B3":[103],"(CVB3)":[104],"poliovirus":[106],"displayed":[107],"high":[109],"genetic":[110],"barrier":[111],"GPC-N114.":[115,194],"By":[116],"contrast,":[117],"EMCV,":[118],"cardiovirus,":[120],"rapidly":[121],"acquired":[122],"due":[124,216],"mutations":[126],"3Dpol.":[128],"In":[129,233],"vitro":[130],"assays":[133],"showed":[134],"that":[135,211,220,241,256],"i)":[137],"inhibited":[138],"elongation":[140],"recombinant":[143],"CVB3":[144,184],"EMCV":[146,153,207],"3Dpol,":[147],"(ii)":[148],"had":[149],"reduced":[150],"3Dpol":[154,166,185,208],"mutations,":[158],"(iii)":[160],"was":[161],"most":[162],"efficient":[163],"inhibiting":[165],"when":[167],"added":[168],"before":[169],"template-primer":[172],"duplex.":[173],"Elucidation":[174],"crystal":[177,202],"structure":[178],"inhibitor":[181],"bound":[182],"confirmed":[186],"RNA-binding":[188],"channel":[189,246],"as":[190],"Docking":[195],"studies":[196],"compound":[199],"into":[200,273],"structures":[203],"compound-resistant":[206],"mutants":[209],"suggested":[210],"resistant":[213],"phenotype":[214],"subtle":[218],"changes":[219],"interfere":[221],"binding":[224,282],"not":[228],"template-primer.":[232],"conclusion,":[234],"this":[235,267],"study":[236,268],"presents":[237],"first":[239],"NNI":[240],"targets":[242],"template":[245,281],"identifies":[252],"new":[254,271],"pocket":[255],"can":[257],"be":[258],"used":[259],"design":[262],"inhibitors.":[265],"Moreover,":[266],"provides":[269],"insight":[272],"plasticity":[275],"polymerases":[278],"at":[279],"site.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}