{"id":"https://openalex.org/W2009146972","doi":"https://doi.org/10.1159/000237227","title":"Decrease in Systemic Tolerance to Fed Ovalbumin in Indomethacin-Treated Mice","display_name":"Decrease in Systemic Tolerance to Fed Ovalbumin in Indomethacin-Treated Mice","publication_year":2009,"publication_date":"2009-09-04","ids":{"openalex":"https://openalex.org/W2009146972","doi":"https://doi.org/10.1159/000237227","mag":"2009146972","pmid":"https://pubmed.ncbi.nlm.nih.gov/8527946"},"language":"en","primary_location":{"id":"doi:10.1159/000237227","doi":"https://doi.org/10.1159/000237227","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000237227","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/bitstream/2268/16543/1/Decrease%20in%20Systemic%20Tolerance%20to%20Fed%20Ovalbumin%20in%20Indomethacin-treated%20mice.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065356435","display_name":"Edouard J. Louis","orcid":"https://orcid.org/0000-0002-1287-7075","observed_orcids":["https://orcid.org/0000-0002-1287-7075"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Louis","raw_affiliation_strings":["Department of Gastroenterology, CHU of Li\u00e8ge, Belgium","Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, CHU of Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]},{"raw_affiliation_string":"Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029097636","display_name":"Denis Paul Franchimont","orcid":"https://orcid.org/0000-0001-8856-3462","observed_orcids":["https://orcid.org/0000-0001-8856-3462"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"D. Franchimont","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge - ULg > D\u00e9partement des sciences cliniques > H\u00e9pato-gastroent\u00e9rologie >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULg > D\u00e9partement des sciences cliniques > H\u00e9pato-gastroent\u00e9rologie >","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040121537","display_name":"Manuel Deprez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Deprez","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge - ULg > D\u00e9partement des sciences cliniques > Neuropathologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULg > D\u00e9partement des sciences cliniques > Neuropathologie","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063451451","display_name":"Anne Lamproye","orcid":"https://orcid.org/0000-0002-8216-0352","observed_orcids":["https://orcid.org/0000-0002-8216-0352"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A. Lamproye","raw_affiliation_strings":["Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068104272","display_name":"Nicole Schaaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"N. Schaaf","raw_affiliation_strings":["Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > H\u00e9matologie biologique et immuno h\u00e9matologie >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > H\u00e9matologie biologique et immuno h\u00e9matologie >","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113982838","display_name":"P. R. Mahieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. Mahieu","raw_affiliation_strings":["Centre Hospitalier Universitaire de Li\u00e8ge - CHU > immunology >  >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Li\u00e8ge - CHU > immunology >  >  >","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075153118","display_name":"Jacques B\u00e9la\u00efche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Belaiche","raw_affiliation_strings":["Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Li\u00e8ge - CHU >  > Gastro-Ent\u00e9rologie-H\u00e9patologie >","institution_ids":["https://openalex.org/I4210134544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7189,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.71266911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"109","issue":"1","first_page":"21","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/systemic-tolerance","display_name":"systemic tolerance","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oral-tolerance","display_name":"oral tolerance","score":0.6299999952316284},{"id":"https://openalex.org/keywords/nsaid-induced-enteropathy","display_name":"NSAID-induced enteropathy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mucosal-immune-response","display_name":"mucosal immune response","score":0.6299999952316284},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7580000162124634},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.42500001192092896},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.9086588621139526},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.679848313331604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6327396631240845},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.5891952514648438},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5369851589202881},{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.5073093771934509},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.47771406173706055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4761735796928406},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.46193161606788635},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4510917663574219},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.4120488166809082},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37283140420913696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27477210760116577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2457740306854248},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.09153828024864197},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1159/000237227","doi":"https://doi.org/10.1159/000237227","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000237227","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},{"id":"pmid:8527946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8527946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International archives of allergy and immunology","raw_type":"Journal Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/16543","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/16543","pdf_url":"https://orbi.uliege.be/bitstream/2268/16543/1/Decrease%20in%20Systemic%20Tolerance%20to%20Fed%20Ovalbumin%20in%20Indomethacin-treated%20mice.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Archives of Allergy and Immunology, 109 (1), 21-6 (1996)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/66544","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/66544","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Decrease in systemic tolerance to fed ovalbumin in indomethacin-treated mice. <i>International Archives of Allergy and Immunology, 109</i>(1), 21-6.Basel, SwitzerlandS. Karger. (1996).","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/16543","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/16543","pdf_url":"https://orbi.uliege.be/bitstream/2268/16543/1/Decrease%20in%20Systemic%20Tolerance%20to%20Fed%20Ovalbumin%20in%20Indomethacin-treated%20mice.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Archives of Allergy and Immunology, 109 (1), 21-6 (1996)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009146972.pdf","grobid_xml":"https://content.openalex.org/works/W2009146972.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W25029696","https://openalex.org/W272430401","https://openalex.org/W326082147","https://openalex.org/W1864497115","https://openalex.org/W1985449740","https://openalex.org/W1987791487","https://openalex.org/W2026357062","https://openalex.org/W2031717133","https://openalex.org/W2048670600","https://openalex.org/W2051919376","https://openalex.org/W2059605635","https://openalex.org/W2075376701","https://openalex.org/W2403769691","https://openalex.org/W2415080714","https://openalex.org/W2415188996","https://openalex.org/W2475473083","https://openalex.org/W4248625696"],"related_works":["https://openalex.org/W2040499755","https://openalex.org/W4235009593","https://openalex.org/W2916063535","https://openalex.org/W1986937263","https://openalex.org/W2032351241","https://openalex.org/W2082612233","https://openalex.org/W2017993988","https://openalex.org/W2058993307","https://openalex.org/W2048670600","https://openalex.org/W2068338895"],"abstract_inverted_index":{"The":[0,24,33,90,168],"oral":[1,70,141],"administration":[2,142],"of":[3,21,45,69,107,143,151,186,188,198,218],"non-steroidal":[4],"anti-inflammatory":[5],"drugs":[6],"(NSAID)":[7],"to":[8,27,52,83,104,122,165,209],"animals":[9],"induces":[10,147],"a":[11,39,123,160,176,184,194],"quick":[12],"increase":[13,101],"in":[14,85,96,132,145,162,206,215],"intestinal":[15,35,156,190],"permeability":[16,36],"and":[17,42,48,56,59,78,99,114,180,193],"secondary":[18],"inflammatory":[19,29,60],"lesions":[20,30],"the":[22,28,67,79,100,105,118,126,133,140,155,189,216],"intestine.":[23],"mechanisms":[25],"leading":[26,51],"are":[31],"hypothetical.":[32],"increased":[34,149],"could":[37,212],"allow":[38],"greater":[40],"mucosal":[41,55,181],"systemic":[43,57,80,119,163,179,207],"penetration":[44],"fed":[46,87,152],"antigens":[47],"bacterial":[49],"products":[50],"an":[53,148],"abnormal":[54],"immune":[58,81,182],"response":[61,82],"toward":[62],"these":[63],"materials.":[64],"We":[65],"examined":[66],"effect":[68,197],"dosing":[71],"with":[72,88,112,159],"indomethacin":[73,144,199],"on":[74],"ovalbumin":[75,84,91],"serum":[76,92],"levels":[77],"mice":[86,98,146],"ovalbumin.":[89],"level":[93],"was":[94,102,110],"higher":[95],"indomethacin-treated":[97],"proportional":[103],"dose":[106],"indomethacin.":[108],"It":[109],"associated":[111,158],"epithelial":[113,191],"subepithelial":[115],"lesions.":[116],"Moreover,":[117],"humoral":[120],"and,":[121],"lesser":[124],"extent,":[125],"cellular":[127],"tolerance":[128,164,208],"were":[129],"partially":[130],"abrogated":[131],"treated":[134],"mice.":[135],"These":[136],"findings":[137],"suggest":[138],"that":[139],"passage":[150],"antigen":[153,211],"through":[154],"epithelium":[157],"decrease":[161,172,205],"this":[166,171],"antigen.":[167],"reason":[169],"for":[170],"remains":[173],"unclear.":[174],"Besides":[175],"disequilibrium":[177],"between":[178],"responses,":[183],"loss":[185],"integrity":[187],"cells":[192],"direct":[195],"immunomodulating":[196],"may":[200],"also":[201],"be":[202,213],"involved.":[203],"This":[204],"luminal":[210],"involved":[214],"development":[217],"NSAID":[219],"enteropathy.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}