{"id":"https://openalex.org/W2009135355","doi":"https://doi.org/10.1007/s00228-005-0082-y","title":"Lack of effect of growth hormone replacement therapy on CYP1A2 and xanthine oxidase activities in growth hormone\u2013deficient children","display_name":"Lack of effect of growth hormone replacement therapy on CYP1A2 and xanthine oxidase activities in growth hormone\u2013deficient children","publication_year":2006,"publication_date":"2006-01-11","ids":{"openalex":"https://openalex.org/W2009135355","doi":"https://doi.org/10.1007/s00228-005-0082-y","mag":"2009135355","pmid":"https://pubmed.ncbi.nlm.nih.gov/16408225"},"language":"en","primary_location":{"id":"doi:10.1007/s00228-005-0082-y","doi":"https://doi.org/10.1007/s00228-005-0082-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-005-0082-y","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032648192","display_name":"E. Mayayo Sinu\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteban Mayayo-Sinu\u00e9s","raw_affiliation_strings":["Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005343996","display_name":"Ana Fanlo","orcid":"https://orcid.org/0000-0001-8064-8138","observed_orcids":["https://orcid.org/0000-0001-8064-8138"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Fanlo","raw_affiliation_strings":["Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030167986","display_name":"B. Sinu\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Blanca Sinu\u00e9s","raw_affiliation_strings":["Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Department of Pharmacology, Medicine School, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110087814","display_name":"E Mayayo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteban Mayayo","raw_affiliation_strings":["Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110267428","display_name":"Jos\u00e9 Ignacio Labarta","orcid":"https://orcid.org/0000-0003-2832-2266","observed_orcids":["https://orcid.org/0000-0003-2832-2266"]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose I. Labarta","raw_affiliation_strings":["Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027184151","display_name":"\u00c1ngel Garc\u00eda de Jal\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Garc\u00eda de Jal\u00f3n","raw_affiliation_strings":["Laboratory of Biochemistry, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005577699","display_name":"\u00c1ngel Ferrandez Long\u00e1s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Ferr\u00e1ndez-Long\u00e1s","raw_affiliation_strings":["Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, University Hospital \u201cMiguel Servet\u201d, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030167986"],"corresponding_institution_ids":["https://openalex.org/I255234318"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":1.0871,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78195972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"62","issue":"2","first_page":"123","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-growth-hormone","display_name":"recombinant human growth hormone","score":0.890999972820282},{"id":"https://openalex.org/keywords/growth-hormone-replacement-therapy","display_name":"growth hormone replacement therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.8539999723434448},{"id":"https://openalex.org/keywords/caffeine-metabolites","display_name":"caffeine metabolites","score":0.7879999876022339},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5429999828338623},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.8525382280349731},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.8159234523773193},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6653330326080322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6467030048370361},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6383950710296631},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5669310092926025},{"id":"https://openalex.org/C2778162141","wikidata":"https://www.wikidata.org/wiki/Q419223","display_name":"Paraxanthine","level":5,"score":0.43301093578338623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4315980076789856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37593287229537964},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3479638993740082},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34544098377227783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21972116827964783},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.20160052180290222},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.13028410077095032}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00228-005-0082-y","doi":"https://doi.org/10.1007/s00228-005-0082-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-005-0082-y","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:16408225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16408225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W87864994","https://openalex.org/W117505870","https://openalex.org/W625127082","https://openalex.org/W1838133052","https://openalex.org/W1870158705","https://openalex.org/W1950438587","https://openalex.org/W1970003951","https://openalex.org/W1971319304","https://openalex.org/W1973047297","https://openalex.org/W1977376984","https://openalex.org/W1977620197","https://openalex.org/W1978541390","https://openalex.org/W1982556979","https://openalex.org/W1990581413","https://openalex.org/W1992790914","https://openalex.org/W1993780682","https://openalex.org/W2007469691","https://openalex.org/W2021863106","https://openalex.org/W2035865178","https://openalex.org/W2048243713","https://openalex.org/W2061911279","https://openalex.org/W2061921693","https://openalex.org/W2087096604","https://openalex.org/W2090628258","https://openalex.org/W2100199295","https://openalex.org/W2119300034","https://openalex.org/W2133251099","https://openalex.org/W2137391471","https://openalex.org/W2165323524","https://openalex.org/W2281391992","https://openalex.org/W2339044507","https://openalex.org/W2345949320","https://openalex.org/W2397649425","https://openalex.org/W2410540876","https://openalex.org/W2416831162","https://openalex.org/W2465863508"],"related_works":["https://openalex.org/W2321643894","https://openalex.org/W1972006761","https://openalex.org/W2066857545","https://openalex.org/W2002465508","https://openalex.org/W2136768707","https://openalex.org/W2967252230","https://openalex.org/W1979127821","https://openalex.org/W1973047297","https://openalex.org/W2172108932","https://openalex.org/W381953176"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}