{"id":"https://openalex.org/W2009043677","doi":"https://doi.org/10.1021/bc9005464","title":"The Effect of Charge-Reversal Amphiphile Spacer Composition on DNA and siRNA Delivery","display_name":"The Effect of Charge-Reversal Amphiphile Spacer Composition on DNA and siRNA Delivery","publication_year":2010,"publication_date":"2010-04-30","ids":{"openalex":"https://openalex.org/W2009043677","doi":"https://doi.org/10.1021/bc9005464","mag":"2009043677","pmid":"https://pubmed.ncbi.nlm.nih.gov/20433165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052776"},"language":"en","primary_location":{"id":"doi:10.1021/bc9005464","doi":"https://doi.org/10.1021/bc9005464","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc9005464","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052776","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052309941","display_name":"Xiaoxiang Zhang","orcid":"https://orcid.org/0000-0002-7032-7338","observed_orcids":["https://orcid.org/0000-0002-7032-7338"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Xiao-Xiang Zhang","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062228665","display_name":"Carla A. H. Prata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Carla A. H. Prata","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108468287","display_name":"Thomas J. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Thomas J. McIntosh","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125136578","display_name":"Philippe Barth\u00e9l\u00e9my","orcid":"https://orcid.org/0000-0003-3917-0579","observed_orcids":["https://orcid.org/0000-0003-3917-0579"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Philippe Barth\u00e9l\u00e9my","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001975624","display_name":"Mark W. Grinstaff","orcid":"https://orcid.org/0000-0002-5453-3668","observed_orcids":["https://orcid.org/0000-0002-5453-3668"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Mark W. Grinstaff","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemistry, Boston University, Boston, Massachusetts 02215, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, and Inserm, U-869, Universit\u00e9 de Bordeaux, Bordeaux, F-33076, France","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001975624"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210126298"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0765,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72990589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"5","first_page":"988","last_page":"993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-delivery","display_name":"DNA delivery","score":0.5360000133514404},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-transfection","display_name":"DNA transfection","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9338176250457764},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.800683319568634},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.7022994160652161},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6934603452682495},{"id":"https://openalex.org/C2776907736","wikidata":"https://www.wikidata.org/wiki/Q408634","display_name":"Ethidium bromide","level":3,"score":0.6530000567436218},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5192211270332336},{"id":"https://openalex.org/C121745418","wikidata":"https://www.wikidata.org/wiki/Q585536","display_name":"Quenching (fluorescence)","level":3,"score":0.43107423186302185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38411790132522583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2243940234184265},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12762585282325745},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.11989262700080872},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.06606230139732361},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006033","descriptor_name":"Glycylglycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bc9005464","doi":"https://doi.org/10.1021/bc9005464","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc9005464","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:20433165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20433165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2104241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3052776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioconjug Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2104241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3227916417","display_name":"Reversing Electrostatic Interactions for Improved Gene Delivery","funder_award_id":"R01EB005658","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4189731876","display_name":"TRP and AQP Channels:  Modulation of Function, Raft Location by Membrane Lipids","funder_award_id":"R01GM027278","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W55007552","https://openalex.org/W90997337","https://openalex.org/W1547069313","https://openalex.org/W1870205239","https://openalex.org/W1971290197","https://openalex.org/W1976807231","https://openalex.org/W1983219118","https://openalex.org/W1987921090","https://openalex.org/W1991303534","https://openalex.org/W1996748041","https://openalex.org/W1998697301","https://openalex.org/W2001735965","https://openalex.org/W2002689384","https://openalex.org/W2003541330","https://openalex.org/W2004180909","https://openalex.org/W2006075616","https://openalex.org/W2009869719","https://openalex.org/W2011372915","https://openalex.org/W2013117269","https://openalex.org/W2020246410","https://openalex.org/W2022545024","https://openalex.org/W2023549097","https://openalex.org/W2030808879","https://openalex.org/W2040213202","https://openalex.org/W2041056392","https://openalex.org/W2044467264","https://openalex.org/W2045101135","https://openalex.org/W2047609968","https://openalex.org/W2060221489","https://openalex.org/W2061830565","https://openalex.org/W2063695548","https://openalex.org/W2071328859","https://openalex.org/W2080446095","https://openalex.org/W2081498971","https://openalex.org/W2084723990","https://openalex.org/W2086138918","https://openalex.org/W2091955078","https://openalex.org/W2107365393","https://openalex.org/W2113339607","https://openalex.org/W2137323781","https://openalex.org/W2143875501","https://openalex.org/W2144209776","https://openalex.org/W2162194950","https://openalex.org/W2331983675","https://openalex.org/W2407854904","https://openalex.org/W2951981446"],"related_works":["https://openalex.org/W4241167869","https://openalex.org/W4233907689","https://openalex.org/W2089846934","https://openalex.org/W2113339607","https://openalex.org/W1986372165","https://openalex.org/W2623322938","https://openalex.org/W228278199","https://openalex.org/W2025213109","https://openalex.org/W2045812803","https://openalex.org/W2033437031"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,19,68,73,93],"charge-reversal":[3],"amphiphiles":[4,26],"with":[5],"different":[6],"spacers":[7],"separating":[8],"the":[9,12,25,63,66,71,81,86,91],"headgroup":[10],"from":[11,65],"hydrophobic":[13],"chains":[14],"are":[15],"described":[16],"for":[17,102],"delivery":[18],"DNA":[20,35,60,82],"and":[21,39,51],"siRNA.":[22],"Among":[23],"them,":[24],"possessing":[27],"a":[28],"glycine":[29],"spacer":[30],"(e.g.,":[31],"B-GlyGly)":[32],"showed":[33],"effective":[34],"transfection":[36,104],"in":[37,49,70,90],"CHO":[38],"NIH":[40],"3T3":[41],"cells,":[42],"as":[43,45],"well":[44],"siRNA":[46],"gene":[47],"knockdown":[48],"HepG2":[50],"UASMC":[52],"cells.":[53],"Ethidium":[54],"bromide":[55],"quenching":[56],"assays":[57],"revealed":[58],"that":[59,80],"was":[61,83],"released":[62],"fastest":[64],"lipoplex":[67,92],"B-GlyGly":[69],"presence":[72],"esterase.":[74],"Also,":[75],"X-ray":[76],"diffraction":[77],"results":[78],"indicated":[79],"located":[84],"between":[85],"adjacent":[87],"lipid":[88],"bilayers":[89],"B-GlyGly.":[94],"These":[95],"distinct":[96],"features":[97],"appear":[98],"to":[99],"be":[100],"required":[101],"high":[103],"activity.":[105]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
