{"id":"https://openalex.org/W2009033786","doi":"https://doi.org/10.1097/fbp.0b013e32830dc110","title":"Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice","display_name":"Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2009033786","doi":"https://doi.org/10.1097/fbp.0b013e32830dc110","mag":"2009033786","pmid":"https://pubmed.ncbi.nlm.nih.gov/18690110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693185"},"language":"en","primary_location":{"id":"doi:10.1097/fbp.0b013e32830dc110","doi":"https://doi.org/10.1097/fbp.0b013e32830dc110","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fbp.0b013e32830dc110","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068995258","display_name":"Susan B. Powell","orcid":"https://orcid.org/0000-0002-7474-9300","observed_orcids":["https://orcid.org/0000-0002-7474-9300"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan B. Powell","raw_affiliation_strings":["aDepartment of Psychiatry, University of California, San Diego, La Jolla, California 92093-0804, USA. sbpowell@ucsd.edu","Department of Psychiatry, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Psychiatry, University of California, San Diego, La Jolla, California 92093-0804, USA. sbpowell@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028559117","display_name":"Jared W. Young","orcid":"https://orcid.org/0000-0003-3732-5776","observed_orcids":["https://orcid.org/0000-0003-3732-5776"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared W. Young","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078075283","display_name":"Jacob C. Ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob C. Ong","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007698609","display_name":"Marc G. Caron","orcid":"https://orcid.org/0000-0003-0172-2710","observed_orcids":["https://orcid.org/0000-0003-0172-2710"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc G. Caron","raw_affiliation_strings":["Departments of Cell Biology, Medicine, and Neurobiology, Duke University Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell Biology, Medicine, and Neurobiology, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034576114","display_name":"Mark A. Geyer","orcid":"https://orcid.org/0000-0001-6137-9331","observed_orcids":["https://orcid.org/0000-0001-6137-9331"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Geyer","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068995258"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":3.2582,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.90641277,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"19","issue":"5-6","first_page":"562","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.906000018119812},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sensorimotor-gating","display_name":"sensorimotor gating","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dopamine-transporter-knockout-mice","display_name":"dopamine transporter knockout mice","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dopamine-dysregulation","display_name":"dopamine dysregulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.931990921497345},{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.8463782072067261},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.8447141647338867},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8345625996589661},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6701275706291199},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.65303635597229},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5876787900924683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5101340413093567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4636486768722534},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.43636682629585266},{"id":"https://openalex.org/C2779705967","wikidata":"https://www.wikidata.org/wiki/Q2271368","display_name":"Sensory gating","level":3,"score":0.42441922426223755},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3552679717540741},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34480077028274536},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.2903807759284973},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27764493227005005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26282113790512085},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22444051504135132},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.11692747473716736},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.09573951363563538}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013216","descriptor_name":"Reflex, Startle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013216","descriptor_name":"Reflex, Startle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/fbp.0b013e32830dc110","doi":"https://doi.org/10.1097/fbp.0b013e32830dc110","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fbp.0b013e32830dc110","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},{"id":"pmid:18690110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18690110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Behav Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2693185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Behav Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1924772474","display_name":"Dopamine Receptors: Characterization and Regulation","funder_award_id":"R01NS019576","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2304933256","display_name":null,"funder_award_id":"MH42228","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3289562758","display_name":"SENSORY GATING AND HABITUATION IN SCHIZOPHRENIA","funder_award_id":"R37MH042228","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G478056362","display_name":"INHIBITORY DEFICITS IN HUMAN AND ANIMAL MODELS OF BIPOLAR DISORDER","funder_award_id":"R01MH071916","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5234085428","display_name":"Gating and Inhibiting in Schizophrenia","funder_award_id":"R01MH042228","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8632272731","display_name":"Conte Centers for the Neuroscience of Depression","funder_award_id":"P50MH060451","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W3049811","https://openalex.org/W329940318","https://openalex.org/W1542676884","https://openalex.org/W1968524760","https://openalex.org/W1979107839","https://openalex.org/W1979700184","https://openalex.org/W1998184647","https://openalex.org/W1999426808","https://openalex.org/W2000517597","https://openalex.org/W2005756201","https://openalex.org/W2009647703","https://openalex.org/W2014793858","https://openalex.org/W2029337932","https://openalex.org/W2042123414","https://openalex.org/W2042676846","https://openalex.org/W2061779222","https://openalex.org/W2068758238","https://openalex.org/W2082983152","https://openalex.org/W2084057859","https://openalex.org/W2085817655","https://openalex.org/W2090979638","https://openalex.org/W2105257553","https://openalex.org/W2123933616","https://openalex.org/W2133067994","https://openalex.org/W2136410515","https://openalex.org/W2151219788","https://openalex.org/W2167982093"],"related_works":["https://openalex.org/W2013557366","https://openalex.org/W7099932890","https://openalex.org/W2029337932","https://openalex.org/W2094391126","https://openalex.org/W2056438092","https://openalex.org/W2005756201","https://openalex.org/W2008745199","https://openalex.org/W2048517805","https://openalex.org/W1979733298","https://openalex.org/W2112891613"],"abstract_inverted_index":{"Sensorimotor":[0],"gating":[1],"disruptions":[2],"are":[3,45],"seen":[4],"in":[5,34,54,77,100],"various":[6],"psychiatric":[7,102],"illnesses":[8,103],"with":[9,65],"putatively":[10],"different":[11],"pathologies,":[12],"including":[13],"schizophrenia":[14,49],"and":[15,37,50],"bipolar":[16],"disorder.":[17],"Interestingly,":[18],"mice":[19,86],"lacking":[20],"the":[21,95],"dopamine":[22],"(DA)":[23],"transporter":[24],"(DAT)":[25],"gene":[26],"display":[27],"markedly":[28],"increased":[29],"levels":[30],"of":[31,48,97],"DA,":[32],"deficits":[33,76],"sensorimotor":[35],"gating,":[36],"hyperactivity":[38],"relative":[39],"to":[40],"wild-type":[41],"mice.":[42,81],"Atypical":[43],"antipsychotics":[44],"effective":[46],"treatments":[47],"manic":[51],"symptoms,":[52],"presumably":[53],"part":[55],"by":[56,105],"antagonizing":[57],"DA":[58,108],"receptors.":[59],"Here":[60],"we":[61],"report":[62],"that":[63],"treatment":[64],"clozapine":[66],"(3":[67],"mg/kg)":[68,72],"or":[69],"quetiapine":[70],"(2.5":[71],"attenuated":[73],"prepulse":[74],"inhibition":[75],"male":[78,83],"DAT":[79,84],"knockout":[80,85],"Thus":[82],"may":[87],"provide":[88],"a":[89,106],"useful":[90],"animal":[91],"model":[92],"for":[93],"predicting":[94],"efficacy":[96],"novel":[98],"drugs":[99],"treating":[101],"characterized":[104],"dysregulated":[107],"system.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}