{"id":"https://openalex.org/W2008998473","doi":"https://doi.org/10.1016/s0009-9236(01)78384-1","title":"Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test","display_name":"Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2008998473","doi":"https://doi.org/10.1016/s0009-9236(01)78384-1","mag":"2008998473","pmid":"https://pubmed.ncbi.nlm.nih.gov/11673748"},"language":"en","primary_location":{"id":"doi:10.1016/s0009-9236(01)78384-1","doi":"https://doi.org/10.1016/s0009-9236(01)78384-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-9236(01)78384-1","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105125841","display_name":"Kari Laine","orcid":"https://orcid.org/0009-0003-4124-7333","observed_orcids":["https://orcid.org/0009-0003-4124-7333"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":true,"raw_author_name":"Kari Laine","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038555087","display_name":"Gunnel Tybring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Gunnel Tybring","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023011657","display_name":"Sebastian H\u00e4rtter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Sebastian H\u00e4rtter","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103686397","display_name":"Katarina Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Katarina Andersson RN","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112063029","display_name":"Jan\u2010Olof Svensson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Jan\u2010Olof Svensson","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033519212","display_name":"Jolanta Wid\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Jolanta Wid\u00e9n","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111567063","display_name":"Leif Bertilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Leif Bertilsson","raw_affiliation_strings":["Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5105125841"],"corresponding_institution_ids":["https://openalex.org/I155660961","https://openalex.org/I28166907"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":4.0498,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.94438034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"4","first_page":"327","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8579999804496765},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/antidepressant-non-response","display_name":"antidepressant non-response","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cyp2d6-inhibition","display_name":"CYP2D6 inhibition","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.503000020980835},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5260000228881836},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.4440000057220459},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.625}],"concepts":[{"id":"https://openalex.org/C2780779033","wikidata":"https://www.wikidata.org/wiki/Q61387","display_name":"Nortriptyline","level":3,"score":0.9583716988563538},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.839971125125885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6787117719650269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6181667447090149},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.5778292417526245},{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.51307213306427},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5099884271621704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39136913418769836},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.28599026799201965},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.10465416312217712},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.07217353582382202},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003647","descriptor_name":"Debrisoquin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003647","descriptor_name":"Debrisoquin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003647","descriptor_name":"Debrisoquin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007024","descriptor_name":"Hypotension, Orthostatic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009661","descriptor_name":"Nortriptyline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009661","descriptor_name":"Nortriptyline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009661","descriptor_name":"Nortriptyline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009661","descriptor_name":"Nortriptyline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009661","descriptor_name":"Nortriptyline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014987","descriptor_name":"Xerostomia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065690","descriptor_name":"Cytochrome P-450 CYP2D6 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/s0009-9236(01)78384-1","doi":"https://doi.org/10.1016/s0009-9236(01)78384-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-9236(01)78384-1","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"doi:10.1067/mcp.2001.118523","doi":"https://doi.org/10.1067/mcp.2001.118523","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mcp.2001.118523","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:11673748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"pmid:11673754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"mag:2036182692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1732494661","https://openalex.org/W1785362826","https://openalex.org/W1828786787","https://openalex.org/W1921815852","https://openalex.org/W1922592185","https://openalex.org/W1922681024","https://openalex.org/W1970744801","https://openalex.org/W1980243802","https://openalex.org/W1982290436","https://openalex.org/W1984518347","https://openalex.org/W1985892376","https://openalex.org/W1994311873","https://openalex.org/W1995826486","https://openalex.org/W2001214229","https://openalex.org/W2001498877","https://openalex.org/W2001836787","https://openalex.org/W2003410018","https://openalex.org/W2008208003","https://openalex.org/W2020563114","https://openalex.org/W2022449643","https://openalex.org/W2034821383","https://openalex.org/W2039001735","https://openalex.org/W2039419498","https://openalex.org/W2041253701","https://openalex.org/W2046436667","https://openalex.org/W2052733258","https://openalex.org/W2058766187","https://openalex.org/W2059222048","https://openalex.org/W2069157036","https://openalex.org/W2071332031","https://openalex.org/W2072371345","https://openalex.org/W2074209497","https://openalex.org/W2074792668","https://openalex.org/W2075447512","https://openalex.org/W2076744665","https://openalex.org/W2076785795","https://openalex.org/W2078386303","https://openalex.org/W2090362914","https://openalex.org/W2094733664","https://openalex.org/W2097633000","https://openalex.org/W2113915156","https://openalex.org/W2117539624","https://openalex.org/W2118660038","https://openalex.org/W2125471714","https://openalex.org/W2126561023","https://openalex.org/W2127361245","https://openalex.org/W2131027628","https://openalex.org/W2156412357","https://openalex.org/W2159150139","https://openalex.org/W2166629377","https://openalex.org/W2404294586","https://openalex.org/W2415125722","https://openalex.org/W3103908430"],"related_works":["https://openalex.org/W2032996390","https://openalex.org/W2329763021","https://openalex.org/W3040047251","https://openalex.org/W2007367734","https://openalex.org/W2045831778","https://openalex.org/W2066453077","https://openalex.org/W2101264455","https://openalex.org/W1732494661","https://openalex.org/W2124470239","https://openalex.org/W2018102328"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,295],"ultrarapid":[2,52,74,399],"metabolizer":[3,244,309],"phenotype":[4,172,310],"of":[5,17,26,35,47,51,56,150,158,186,221,255,291,349,367,397],"the":[6,48,98,104,118,124,131,143,148,154,165,170,184,229,240,271,306,347,353,359,362,371,394],"cytochrome":[7],"P4502D6":[8],"(CYP2D6)":[9],"enzyme":[10],"has":[11],"been":[12],"considered":[13],"a":[14,61,77,90,114,140,226,234,259,275,314,380],"relevant":[15],"cause":[16],"nonresponse":[18],"to":[19,28,32,65,228,239,304,385],"antidepressant":[20],"drug":[21,196],"therapy.":[22],"Prescribing":[23],"high":[24,33,296],"doses":[25],"antidepressants":[27],"such":[29,68],"patients":[30,69],"leads":[31],"concentrations":[34,212,250,298,351],"potentially":[36],"toxic":[37],"metabolites":[38],"and":[39,101,120,130,182,198,246,311,339],"an":[40,389],"increased":[41],"risk":[42],"for":[43,92,199],"adverse":[44,191,368],"reactions.":[45],"Normalization":[46],"metabolic":[49,395],"status":[50,396],"metabolizers":[53,75],"by":[54,175,289],"inhibition":[55,288],"CYP2D6":[57,78,105,171,398],"activity":[58],"could":[59],"offer":[60],"clinically":[62],"acceptable":[63],"method":[64],"successfully":[66],"treat":[67],"with":[70,76,85,103,135,217,379],"antidepressants.":[71],"METHODS:":[72],"Five":[73],"gene":[79],"duplication":[80],"or":[81,110,160],"triplication":[82],"were":[83,133,162,193,251,374],"treated":[84,134],"25":[86],"mg":[87,109,112,138,224],"nortriptyline":[88,127,159,211,218,230,249,265,319,340,350],"twice":[89,113,139,225],"day":[91,141,227],"3":[93,260],"consecutive":[94],"weeks,":[95],"alone":[96],"during":[97,117,142,195],"first":[99],"week":[100,201,365],"concomitantly":[102],"inhibitor":[106],"paroxetine":[107,136,161,222,272,281,290,297,338],"10":[108,223],"20":[111,137,384],"day,":[115],"respectively,":[116],"second":[119,363],"third":[121,125],"weeks.":[122],"After":[123],"week,":[126,153],"was":[128,173,335],"discontinued":[129,358],"subjects":[132,206,257,301],"fourth":[144],"study":[145,152,188,360,364,372],"week.":[146],"At":[147],"end":[149,185],"each":[151,187],"steady-state":[155],"pharmacokinetic":[156],"parameters":[157],"determined":[163,174],"within":[164,352],"dose":[166,273,354],"interval.":[167,355],"In":[168],"addition,":[169],"debrisoquin":[176],"(INN,":[177],"debrisoquine)":[178],"test":[179],"at":[180,183],"baseline":[181],"phase.":[189],"Treatment-related":[190],"events":[192],"recorded":[194],"administration":[197],"1":[200],"thereafter.":[202],"RESULTS:":[203],"All":[204],"5":[205,256],"had":[207],"very":[208],"low":[209],"(subtherapeutic)":[210],"after":[213,258,361],"7":[214],"days'":[215],"treatment":[216],"only.":[219],"Addition":[220],"regimen":[231],"resulted":[232,312],"in":[233,236,253,264,280,299,313,317,392],"change":[235],"all":[237],"individuals":[238],"\"normal\"":[241],"extensive":[242],"debrisoquine":[243,308],"phenotype,":[245],"therapeutic":[247],"plasma":[248,318],"achieved":[252],"4":[254],"times":[261,277],"mean":[262,278],"increase":[263,279,316],"trough":[266,282,320,341],"concentration":[267,283,321],"(P":[268,284,322],"=.0011).":[269],"Doubling":[270],"caused":[274,302],"15":[276],"<.001),":[285],"indicating":[286],"strong":[287,325],"its":[292],"own":[293],"metabolism.":[294],"2":[300],"them":[303],"have":[305],"poor":[307],"further":[315],"=.0099).":[323],"A":[324],"correlation":[326,328],"(rank":[327],"coefficient":[329],"[r(s)]":[330],"=":[331],"0.89;":[332],"P":[333],"<.0001)":[334],"observed":[336],"between":[337],"concentrations.":[342],"Paroxetine":[343],"also":[344],"significantly":[345],"decreased":[346],"fluctuation":[348],"One":[356],"subject":[357],"because":[366],"effects;":[369],"otherwise,":[370],"drugs":[373],"well":[375],"tolerated.":[376],"CONCLUSIONS:":[377],"Paroxetine,":[378],"daily":[381],"dosage":[382],"from":[383],"40":[386],"mg,":[387],"is":[388],"effective":[390],"tool":[391],"normalizing":[393],"metabolizers.":[400]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}