{"id":"https://openalex.org/W2008992496","doi":"https://doi.org/10.1212/wnl.0b013e3182190d09","title":"Midlife overweight and obesity increase late-life dementia risk: A population-based twin study","display_name":"Midlife overweight and obesity increase late-life dementia risk: A population-based twin study","publication_year":2011,"publication_date":"2011-05-02","ids":{"openalex":"https://openalex.org/W2008992496","doi":"https://doi.org/10.1212/wnl.0b013e3182190d09","mag":"2008992496","pmid":"https://pubmed.ncbi.nlm.nih.gov/21536637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3100125"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0b013e3182190d09","doi":"https://doi.org/10.1212/wnl.0b013e3182190d09","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0b013e3182190d09","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2008992496"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3100125","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024473114","display_name":"Weili Xu","orcid":"https://orcid.org/0000-0001-6140-2968","observed_orcids":["https://orcid.org/0000-0001-6140-2968"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"W.L. Xu","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103220135","display_name":"Anna Rita Atti","orcid":"https://orcid.org/0000-0002-6188-2647","observed_orcids":["https://orcid.org/0000-0002-6188-2647"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"A.R. Atti","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063732312","display_name":"Margaret Gatz","orcid":"https://orcid.org/0000-0002-1071-9970","observed_orcids":["https://orcid.org/0000-0002-1071-9970"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"M. Gatz","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011350655","display_name":"Nancy L. Pedersen","orcid":"https://orcid.org/0000-0001-8057-3543","observed_orcids":["https://orcid.org/0000-0001-8057-3543"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"N.L. Pedersen","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021517992","display_name":"Boo E. A. Johansson","orcid":"https://orcid.org/0000-0002-1996-3435","observed_orcids":["https://orcid.org/0000-0002-1996-3435"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"B. Johansson","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016653962","display_name":"Laura Fratiglioni","orcid":"https://orcid.org/0000-0002-6374-6614","observed_orcids":["https://orcid.org/0000-0002-6374-6614"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["CN","IT","SE","US"],"is_corresponding":false,"raw_author_name":"L. Fratiglioni","raw_affiliation_strings":["From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Aging Research Center (W.L.X., A.R.A., L.F.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology (W.L.X.), Tianjin Medical University, Tianjin, China; Psychiatry Institute Paolo Ottonello (A.R.A.), Bologna University, Bologna, Italy; Department of Psychology (M.G., N.L.P.), University of Southern California, Los Angeles; Department of Medical Epidemiology and Biostatistics (M.G., N.L.P.),","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I5740404","https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.3574,"has_fulltext":false,"cited_by_count":500,"citation_normalized_percentile":{"value":0.99789738,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"76","issue":"18","first_page":"1568","last_page":"1574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/midlife-obesity","display_name":"midlife obesity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8090000152587891},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9779999852180481},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":1.0},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9860000014305115},{"id":"https://openalex.org/keywords/late-onset-dementia","display_name":"late-onset dementia","score":0.6299999952316284},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.5950000286102295},{"id":"https://openalex.org/keywords/swedish-twin-registry","display_name":"Swedish Twin Registry","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.826797604560852},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7875668406486511},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.7426449060440063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6147972345352173},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.53486567735672},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33631956577301025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19546717405319214},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15764302015304565}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014427","descriptor_name":"Twins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1212/wnl.0b013e3182190d09","doi":"https://doi.org/10.1212/wnl.0b013e3182190d09","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0b013e3182190d09","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3100125","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3100125","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmid:21536637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21536637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/108674","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/108674","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3100125","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3100125","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7352717633","display_name":"DEMENTIA IN SWEDISH TWINS","funder_award_id":"R01AG008724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1512245923","https://openalex.org/W1581074060","https://openalex.org/W1584562937","https://openalex.org/W1875031981","https://openalex.org/W1969556939","https://openalex.org/W1971559855","https://openalex.org/W1989099784","https://openalex.org/W1989104104","https://openalex.org/W1989113247","https://openalex.org/W2000393022","https://openalex.org/W2001284149","https://openalex.org/W2004298162","https://openalex.org/W2004564420","https://openalex.org/W2022425286","https://openalex.org/W2023397814","https://openalex.org/W2039780651","https://openalex.org/W2043762446","https://openalex.org/W2046006229","https://openalex.org/W2046859247","https://openalex.org/W2058988518","https://openalex.org/W2066630911","https://openalex.org/W2077468399","https://openalex.org/W2081450791","https://openalex.org/W2082266356","https://openalex.org/W2084970815","https://openalex.org/W2101922440","https://openalex.org/W2109876897","https://openalex.org/W2111096378","https://openalex.org/W2112150247","https://openalex.org/W2112229041","https://openalex.org/W2126266321","https://openalex.org/W2128828378","https://openalex.org/W2136354290","https://openalex.org/W2139377504","https://openalex.org/W2147954981","https://openalex.org/W2156220037","https://openalex.org/W2158894504","https://openalex.org/W2159529587","https://openalex.org/W2161336439","https://openalex.org/W2319176243"],"related_works":["https://openalex.org/W1971559855","https://openalex.org/W2780560553","https://openalex.org/W3110811121","https://openalex.org/W656367409","https://openalex.org/W2336474660","https://openalex.org/W1527171303","https://openalex.org/W2160601377","https://openalex.org/W2077468399","https://openalex.org/W4238608606","https://openalex.org/W2074875482"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,205],"relation":[2],"of":[3,15,182,234],"overweight":[4,17,167,225],"to":[5,11,33,44,64,174,199,246],"dementia":[6,27,66,127,175],"is":[7],"controversial.":[8],"We":[9],"aimed":[10],"examine":[12],"the":[13,35,45,50,81,210,213,232,247],"association":[14],"midlife":[16,74,150,171,202,229,248],"and":[18,25,32,39,71,101,121,133,145,168,185,212,226,237,240],"obesity":[19,146,169,227],"with":[20,163,176],"dementia,":[21,235],"Alzheimer":[22],"disease":[23],"(AD),":[24],"vascular":[26,119],"(VaD)":[28],"in":[29,80,130,153,193,207],"late":[30],"life,":[31],"verify":[34],"hypothesis":[36],"that":[37],"genetic":[38],"early-life":[40,241],"environmental":[41,242],"factors":[42,243],"contribute":[43,245],"observed":[46],"association.":[47,204,251],"METHODS:":[48],"From":[49],"Swedish":[51],"Twin":[52],"Registry,":[53],"8,534":[54],"twin":[55,109,196],"individuals":[56],"aged":[57],"\u226565":[58],"(mean":[59,75],"age":[60,76],"74.4)":[61],"were":[62,78,84,151,172],"assessed":[63],"detect":[65],"cases":[67],"(DSM-IV":[68],"criteria).":[69],"Height":[70],"weight":[72],"at":[73,149,170,228],"43.4)":[77],"available":[79],"Registry.":[82],"Data":[83],"analyzed":[85],"as":[86],"follows:":[87],"1)":[88],"unmatched":[89],"case-control":[90,105,215],"analysis":[91,192,216],"for":[92,107],"all":[93,125],"twins":[94],"using":[95],"generalized":[96],"estimating":[97],"equation":[98],"(GEE)":[99],"models":[100],"2)":[102],"cotwin":[103],"matched":[104,214],"approach":[106],"dementia-discordant":[108,195],"pairs":[110,197],"by":[111],"conditional":[112],"logistic":[113,190],"regression":[114,191],"taking":[115],"into":[116],"account":[117],"lifespan":[118],"disorders":[120],"diabetes.":[122],"RESULTS:":[123],"Among":[124],"participants,":[126],"was":[128,217],"diagnosed":[129],"350":[131],"subjects,":[132],"114":[134],"persons":[135],"had":[136],"questionable":[137],"dementia.":[138],"Overweight":[139],"(body":[140],"mass":[141],"index":[142],"[BMI]":[143],">25-30)":[144],"(BMI":[147],">30)":[148],"present":[152],"2,541":[154],"(29.8%)":[155],"individuals.":[156],"In":[157],"fully":[158],"adjusted":[159],"GEE":[160,211],"models,":[161],"compared":[162],"normal":[164],"BMI":[165],"(20-25),":[166],"related":[173],"odds":[177],"ratios":[178],"(ORs)":[179],"(95%":[180],"CIs)":[181],"1.71":[183],"(1.30-2.25)":[184],"3.88":[186],"(2.12-7.11),":[187],"respectively.":[188],"Conditional":[189],"137":[194],"led":[198],"an":[200],"attenuated":[201],"BMI-dementia":[203],"difference":[206],"ORs":[208],"from":[209],"statistically":[218],"significant":[219],"(p":[220],"=":[221],"0.019).":[222],"CONCLUSIONS:":[223],"Both":[224],"independently":[230],"increase":[231],"risk":[233],"AD,":[236],"VaD.":[238],"Genetic":[239],"may":[244],"high":[249],"adiposity-dementia":[250]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":33},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":40},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
