{"id":"https://openalex.org/W2008960773","doi":"https://doi.org/10.1681/asn.2005030294","title":"Amelioration of Acute Renal Failure by Stem Cell Therapy\u2014Paracrine Secretion Versus Transdifferentiation into Resident Cells","display_name":"Amelioration of Acute Renal Failure by Stem Cell Therapy\u2014Paracrine Secretion Versus Transdifferentiation into Resident Cells","publication_year":2005,"publication_date":"2005-04-27","ids":{"openalex":"https://openalex.org/W2008960773","doi":"https://doi.org/10.1681/asn.2005030294","mag":"2008960773"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2005030294","doi":"https://doi.org/10.1681/asn.2005030294","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2005030294","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059411683","display_name":"Florian E. Togel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Togel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089358188","display_name":"Zhenwu Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112889456","display_name":"Kathy Weiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021692","display_name":"J Isaac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Isaac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865492","display_name":"Claudia Lange","orcid":"https://orcid.org/0000-0002-3130-3982","observed_orcids":["https://orcid.org/0000-0002-3130-3982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Lange","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089201168","display_name":"C. Westenfelder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Westenfelder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0142,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69847442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"5","first_page":"1153","last_page":"1155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/paracrine-secretion","display_name":"paracrine secretion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/renal-tubular-regeneration","display_name":"renal tubular regeneration","score":0.6850000023841858},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cell-engraftment","display_name":"cell engraftment","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.8603384494781494},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7909350991249084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6645416021347046},{"id":"https://openalex.org/C138798377","wikidata":"https://www.wikidata.org/wiki/Q7312502","display_name":"Renal stem cell","level":4,"score":0.6472577452659607},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6313130855560303},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.576391339302063},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5659414529800415},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5251895189285278},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.44578611850738525},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.43850433826446533},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.43320998549461365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3289450705051422},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3225018382072449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2343847155570984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21400287747383118},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.11445304751396179},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07404842972755432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.2005030294","doi":"https://doi.org/10.1681/asn.2005030294","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2005030294","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"mag:2186961463","doi":null,"is_oa":false,"landing_page_url":"https://jasn.asnjournals.org/content/16/5/1153.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W131003225","https://openalex.org/W151717776","https://openalex.org/W158481431","https://openalex.org/W180946569","https://openalex.org/W249892540","https://openalex.org/W317713190","https://openalex.org/W1540221256","https://openalex.org/W1569560733","https://openalex.org/W1631250427","https://openalex.org/W1655860314","https://openalex.org/W1832821854","https://openalex.org/W1972845462","https://openalex.org/W1973294950","https://openalex.org/W1978350136","https://openalex.org/W1982245891","https://openalex.org/W1984312778","https://openalex.org/W1984878255","https://openalex.org/W1985299393","https://openalex.org/W1985460201","https://openalex.org/W1987380247","https://openalex.org/W1987584618","https://openalex.org/W1991374176","https://openalex.org/W1994654392","https://openalex.org/W1995217040","https://openalex.org/W1999052450","https://openalex.org/W2000783979","https://openalex.org/W2003298230","https://openalex.org/W2020204891","https://openalex.org/W2023315677","https://openalex.org/W2026351725","https://openalex.org/W2031111667","https://openalex.org/W2032311016","https://openalex.org/W2042137853","https://openalex.org/W2044276013","https://openalex.org/W2044334355","https://openalex.org/W2045888731","https://openalex.org/W2046581351","https://openalex.org/W2047610167","https://openalex.org/W2047912800","https://openalex.org/W2048842878","https://openalex.org/W2049271109","https://openalex.org/W2051871991","https://openalex.org/W2054188291","https://openalex.org/W2057133669","https://openalex.org/W2060127044","https://openalex.org/W2061508089","https://openalex.org/W2062888334","https://openalex.org/W2064019766","https://openalex.org/W2068364493","https://openalex.org/W2068380542","https://openalex.org/W2068402718","https://openalex.org/W2070231299","https://openalex.org/W2079489649","https://openalex.org/W2082433081","https://openalex.org/W2082800289","https://openalex.org/W2084050769","https://openalex.org/W2089082626","https://openalex.org/W2089538060","https://openalex.org/W2091310406","https://openalex.org/W2094947541","https://openalex.org/W2095666785","https://openalex.org/W2095974470","https://openalex.org/W2096875294","https://openalex.org/W2107031719","https://openalex.org/W2110667326","https://openalex.org/W2115363040","https://openalex.org/W2116097769","https://openalex.org/W2116430084","https://openalex.org/W2118305788","https://openalex.org/W2120963263","https://openalex.org/W2123831918","https://openalex.org/W2129852286","https://openalex.org/W2133408276","https://openalex.org/W2133812093","https://openalex.org/W2135960771","https://openalex.org/W2138689448","https://openalex.org/W2139968474","https://openalex.org/W2140979322","https://openalex.org/W2142862239","https://openalex.org/W2144160997","https://openalex.org/W2145785082","https://openalex.org/W2149734505","https://openalex.org/W2150893441","https://openalex.org/W2151722542","https://openalex.org/W2151762277","https://openalex.org/W2153625868","https://openalex.org/W2154502936","https://openalex.org/W2154935039","https://openalex.org/W2156203281","https://openalex.org/W2158953656","https://openalex.org/W2160648938","https://openalex.org/W2164194790","https://openalex.org/W2164409045","https://openalex.org/W2166692224","https://openalex.org/W2168416719","https://openalex.org/W2305118939","https://openalex.org/W2324579467","https://openalex.org/W2335631045","https://openalex.org/W2395703833","https://openalex.org/W2405244915","https://openalex.org/W2412420952","https://openalex.org/W2413274194","https://openalex.org/W2981029611","https://openalex.org/W3146946920"],"related_works":["https://openalex.org/W2060234615","https://openalex.org/W2115363040","https://openalex.org/W2087154146","https://openalex.org/W2212963078","https://openalex.org/W2138616895","https://openalex.org/W1537683538","https://openalex.org/W2045475041","https://openalex.org/W2024598117","https://openalex.org/W2086408268","https://openalex.org/W7217542207"],"abstract_inverted_index":{"Although":[0],"the":[1,52,70,91,95,105,145,160,175,204,228,236,249,312,319,346,375,397,465,578,583,613,628,650,670,676,684,689,708,720,723,745,766,786,814,838,923],"kidney":[2,53,685],"has":[3,361,378,460,848],"been":[4,244,297,380,412,462],"suspected,":[5],"though":[6],"not":[7,74,123,306,379,703,772,894],"definitively":[8],"proven,":[9],"to":[10,177,227,246,290,345,440,538,635,736,740,811,849,851,857,905,917,925],"contain":[11],"organ-specific":[12],"pluripotent":[13,282],"stem":[14,38,66,79,115,181,224,284,388,425,505,777,816,829,861,890],"cells,":[15,67,127,782,862],"their":[16,271,531,536],"role":[17,35,743],"in":[18,40,61,203,210,365,471,477,620,627,649,675,683,744,763,823,832],"regeneration":[19,229],"after":[20,58,75,84,214,254,367,433,586,589,698],"renal":[21,42,82,96,110,137,184,191,212,231,559,749,780,842,866],"injury":[22,57,135,186,658],"is":[23,341],"uncertain":[24],"(1\u20133).":[25],"Recently,":[26],"however,":[27,308,643],"several":[28,852],"investigators":[29],"found":[30,733],"evidence":[31,404],"for":[32,275,563,655,688],"a":[33,338,742,806,884,896,929],"renoprotective":[34],"of":[36,51,60,77,90,108,113,118,125,142,156,190,197,230,238,281,286,321,331,387,396,457,467,474,573,582,595,601,680,691,700,704,710,722,769,776,788,793,797,860,865],"non\u2013organ-specific":[37],"cells":[39,93,116,182,194,200,225,260,285,317,389,437,483,488,529,584,778],"acute":[41,109,211,748],"failure.":[43],"Arriero":[44],"et":[45,101,164,218,334,513],"al.":[46,102,165,219,335],"(4)":[47],"reported":[48],"dramatic":[49],"protection":[50],"against":[54,132,406],"ischemia/":[55],"reperfusion":[56],"injection":[59,76,124,600,699],"vitro":[62],"expanded":[63],"skeletal":[64],"muscle-derived":[65],"differentiated":[68],"along":[69],"endothelial":[71,443],"lineage":[72],"(but":[73],"nondifferentiated":[78],"cells).":[80],"The":[81,267,303,328,428,544,558,759,800,818],"function":[83],"ischemia":[85],"was":[86,98,152,431,533,673,717,727,732,784,802,809],"improved":[87],"and":[88,136,172,187,401,421,451,486,530,542,566,622,640,669,719,795,805,898,910],"engraftment":[89,141],"transplanted":[92],"into":[94,144,390,540,577,779],"microvasculature":[97],"documented.":[99],"Morigi":[100],"(5)":[103],"studied":[104],"cisplatin":[106],"model":[107,765],"failure:":[111],"Injection":[112],"mesenchymal":[114],"(MSC)":[117],"bone":[119,179,198,315,434,755],"marrow":[120],"origin,":[121],"but":[122,374,702,783],"hematopoietic":[126,223],"protected":[128],"syngeneic":[129,604],"female":[130,240],"mice":[131],"severe":[133],"tubular":[134,148,185,205,232],"functional":[138],"impairment.":[139],"Furthermore,":[140,193],"MSC":[143,476,515,545,569,615,644,770],"vigorously":[146],"proliferating":[147],"epithelial":[149,206,233],"cell":[150,207,309,323,359,426,830,891],"layer":[151],"documented":[153,202],"by":[154,276,299,325,424,464,503,510,525,535,548,660],"demonstration":[155],"Y-chromosome\u2013containing":[157],"cells.":[158,234,506,817],"In":[159,235,507],"same":[161],"model,":[162],"Iwasaki":[163],"(6)":[166],"showed":[167,221,251],"that":[168,222,242,252,270,314,498,762,874],"pretreatment":[169],"with":[170,174,479,599,734,825,828,840,855,903],"G-CSF":[171],"M-CSF":[173],"rationale":[176],"mobilize":[178],"marrow\u2013derived":[180,199,316,435],"prevented":[183],"accelerated":[188],"recovery":[189,594,746],"function.":[192],"expressing":[195],"markers":[196,611],"were":[201,265,438,516,522,546,556,561,575,633,645,667],"layer.":[208],"Finally,":[209],"failure":[213,750],"ischemia/reperfusion":[215,587],"injury,":[216,867],"Lin":[217],"(7)":[220],"contributed":[226],"kidneys":[237,651],"nontransgenic":[239],"recipients":[241],"had":[243,295],"subjected":[245],"unilateral":[247],"ischemia,":[248],"authors":[250,268,301,304,760],"still":[253],"4":[255],"wk":[256],"\u03b2-galactosidase\u2013expressing":[257],"Y":[258],"chromosome\u2013positive":[259],"from":[261,385,518,747,774],"transgenic":[262],"male":[263],"donors":[264],"detected.":[266],"suggested":[269,370,413,432],"findings":[272,827],"are":[273,494,501,876],"accounted":[274],"\u201ctransdifferentiation,\u201d":[277],"i.e.,":[278,311],"phenotypic":[279],"conversion":[280],"somatic":[283],"one":[287,847],"tissue":[288,292],"type":[289,293,859],"another":[291],"as":[294,415,527,662,664],"previously":[296],"postulated":[298],"other":[300,322,833],"(8,9).":[302],"could":[305,616],"exclude,":[307],"hybridization,":[310],"possibility":[313,339],"adopted":[318],"phenotype":[320],"lineages":[324],"fusion":[326],"(10,11).":[327],"recent":[329,826],"paper":[330,872],"To[Combining":[332,511],"Diaeresis]gel":[333,512],"now":[336],"introduces":[337],"which":[340],"alternative":[342,409],"or":[343,588,603],"complementary":[344],"above":[347,398],"interpretations.":[348],"Some":[349],"background":[350],"information":[351],"may":[352],"be":[353,617,822,895,914,926],"helpful":[354],"at":[355],"this":[356,407,472,508,764,845,870],"point.":[357],"Stem":[358],"therapy":[360,831,892],"gained":[362],"much":[363,877,930],"attention":[364],"cardiology":[366],"controlled":[368,804],"trials":[369],"its":[371,906],"efficacy":[372],"(12,13),":[373],"mechanism":[376,430],"involved":[377],"clearly":[381],"defined":[382],"(14).":[383],"Apart":[384],"differentiation":[386],"cardiomyocytes":[391],"(15),":[392],"somewhat":[393],"dubious":[394],"because":[395],"caveat":[399],"(10,11)":[400],"some":[402,632,737],"new":[403],"(16)":[405],"possibility,":[408],"possibilities":[410],"have":[411,922],"such":[414,504],"angiogenesis":[416],"(i.e.,":[417],"capillary":[418],"formation)":[419],"(17,18)":[420],"paracrine":[422,458,692,789],"effects":[423,459,790],"secretions.":[427],"latter":[429],"mononuclear":[436],"shown":[439],"express":[441],"vascular":[442],"growth":[444,449],"factor":[445],"(VEGF),":[446],"basic":[447],"fibroblast":[448,705],"factor,":[450],"angiopoietins":[452],"(19\u201321).":[453],"An":[454],"impressive":[455],"example":[456],"also":[461,821],"provided":[463,686],"documentation":[466],"an":[468],"immunomodulatory":[469],"effect,":[470],"case":[473],"allogeneic":[475],"cocultures":[478],"immune":[480],"cells:":[481],"T(H)1":[482],"decreased":[484],"IFN-\u03b3":[485],"T(H)2":[487],"increased":[489],"IL-4":[490],"secretion":[491],"(22).":[492],"There":[493],"even":[495],"unpublished":[496],"observations":[497],"graft-versus-host":[499],"reactions":[500],"mitigated":[502],"study":[509,801],"al.,":[514],"isolated":[517],"rat":[519,554],"femurs.":[520],"They":[521],"well":[523,663,803],"characterized":[524],"isolation":[526],"adherent":[528],"specificity":[532],"validated":[534],"ability":[537],"differentiate":[539],"osteocytes":[541],"adipocytes.":[543],"fluorescence-labeled":[547,614],"carboxy-fluorescein":[549],"diacetate":[550],"(CFDA).":[551],"Two":[552],"different":[553,607,653],"strains":[555],"used.":[557],"arteries":[560],"clamped":[562],"40":[564],"min":[565],"thereafter":[567],"106":[568],"(or":[570],"equal":[571],"numbers":[572],"fibroblasts)":[574],"injected":[576,815],"carotid":[579],"artery.":[580],"Administration":[581],"immediately":[585],"24":[590,639],"h":[591],"caused":[592],"faster":[593],"serum":[596],"creatinine":[597],"compared":[598],"vehicle":[602],"fibroblasts.":[605],"Using":[606],"techniques":[608,654],"including":[609],"genetic":[610],"(Y-chromosome),":[612],"transiently":[618],"detected":[619],"control":[621,706],"postischemic":[623],"kidneys,":[624],"surprisingly":[625],"mostly":[626],"glomerular":[629],"capillaries":[630],"although":[631],"attached":[634],"peritubular":[636],"capillaries.":[637],"After":[638],"72":[641],"h,":[642],"no":[646,730],"longer":[647],"demonstrable":[648],"using":[652],"detection.":[656],"Renal":[657],"scores":[659,666],"histology":[661],"apoptosis":[665],"lower":[668,718],"mitogenic":[671],"index":[672],"higher":[674,931],"MSC-treated":[677],"animals.":[678],"Measurement":[679],"gene":[681],"expression":[682,709,721],"support":[687],"hypothesis":[690],"actions.":[693],"By":[694],"real":[695],"time":[696,863],"PCR":[697],"MSC,":[701],"injection,":[707],"proinflammatory":[711,794],"cytokines":[712],"(IL-1\u03b2,":[713],"TNF-\u03b1,":[714],"INF\u03b3,":[715],"iNOS)":[716],"anti-inflammatory":[724,798],"cytokine":[725],"IL-10":[726],"higher,":[728],"while":[729],"difference":[731],"respect":[735,856,904],"molecules":[738],"known":[739],"play":[741],"(e.g.,":[751],"VEGF-A,-B,-C,-D;":[752],"EGF;":[753],"IGF-1;":[754],"morphogenetic":[756],"protein\u20137":[757],"[BMP7]).":[758],"concluded":[761],"beneficial":[767],"effect":[768],"did":[771],"result":[773,787],"transdifferentiation":[775],"parenchymal":[781],"primarily":[785],"causing":[791],"downregulation":[792],"upregulation":[796],"cytokines.":[799],"laudable":[807],"effort":[808],"made":[810],"strictly":[812],"characterize":[813],"conclusion":[819],"would":[820],"line":[824],"organs":[834],"(21,22).":[835],"To":[836],"explain":[837],"differences":[839,854],"previous":[841],"studies":[843],"on":[844,928],"topic,":[846],"point":[850],"important":[853],"species,":[858],"course":[864],"etc.":[868],"Nevertheless,":[869],"fascinating":[871],"illustrates":[873],"matters":[875],"more":[878],"complex":[879],"than":[880],"we":[881],"thought":[882],"only":[883],"few":[885],"years":[886],"ago.":[887],"Most":[888],"likely":[889],"will":[893],"panacea":[897],"before":[899],"drawing":[900],"definite":[901],"conclusions":[902],"therapeutic":[907],"potential,":[908],"safety":[909],"feasibility":[911],"issues":[912],"must":[913],"resolved.":[915],"Currently,":[916],"quote":[918],"G.B.":[919],"Shaw,":[920],"\u201cWe":[921],"privilege":[924],"confused":[927],"level.\u201dEberhard":[932],"Ritz:":[933],"Feature":[934],"Editor":[935]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
