{"id":"https://openalex.org/W2008895037","doi":"https://doi.org/10.1093/nar/gks039","title":"DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster","display_name":"DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster","publication_year":2012,"publication_date":"2012-01-28","ids":{"openalex":"https://openalex.org/W2008895037","doi":"https://doi.org/10.1093/nar/gks039","mag":"2008895037","pmid":"https://pubmed.ncbi.nlm.nih.gov/22287629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378879"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gks039","doi":"https://doi.org/10.1093/nar/gks039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks039","pdf_url":"https://academic.oup.com/nar/article-pdf/40/10/4247/7188422/gks039.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/40/10/4247/7188422/gks039.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067232718","display_name":"Yuliang Wu","orcid":"https://orcid.org/0000-0002-4516-7774","observed_orcids":["https://orcid.org/0000-0002-4516-7774"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Y. Wu","raw_affiliation_strings":["Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan, S7N 5E5, Canada. yuliang.wu@usask.ca","Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan S7N 5E5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan, S7N 5E5, Canada. yuliang.wu@usask.ca","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan S7N 5E5, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036007045","display_name":"Robert M. Brosh","orcid":"https://orcid.org/0000-0003-2676-4327","observed_orcids":["https://orcid.org/0000-0003-2676-4327"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"R. M. Brosh","raw_affiliation_strings":["Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan, S7N 5E5, Canada and 2 Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, Baltimore, MD 21224, USA","University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Saskatchewan, Health Sciences Building, Saskatoon, Saskatchewan, S7N 5E5, Canada and 2 Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I32625721","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036007045","https://openalex.org/A5067232718"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I32625721","https://openalex.org/I4210136897"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.6078,"has_fulltext":true,"cited_by_count":150,"citation_normalized_percentile":{"value":0.85350714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"40","issue":"10","first_page":"4247","last_page":"4260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-helicase","display_name":"DNA helicase","score":0.8240000009536743},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":0.968999981880188},{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromosomal-stability","display_name":"chromosome stability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.8140000104904175},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.9443180561065674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.80277019739151},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.6394361853599548},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.600184440612793},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5518907308578491},{"id":"https://openalex.org/C2777852564","wikidata":"https://www.wikidata.org/wiki/Q312085","display_name":"Iron\u2013sulfur cluster","level":3,"score":0.5485162138938904},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5342921614646912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5044516324996948},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4921843111515045},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.4903104603290558},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.4159632921218872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38870030641555786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36744916439056396},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2711337208747864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21146371960639954},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10448801517486572}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019915","descriptor_name":"DNA Primase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gks039","doi":"https://doi.org/10.1093/nar/gks039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks039","pdf_url":"https://academic.oup.com/nar/article-pdf/40/10/4247/7188422/gks039.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3378879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378879","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:22287629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22287629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.8800","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.8800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3a/5f/gks039.PMC3378879.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.941.9012","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.941.9012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2012/01/28/nar.gks039.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.960.9411","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.960.9411","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/40/10/4247.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:nar:40/10/4247","doi":null,"is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/40/10/4247","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/nar/gks039","doi":"https://doi.org/10.1093/nar/gks039","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks039","pdf_url":"https://academic.oup.com/nar/article-pdf/40/10/4247/7188422/gks039.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306947","display_name":"Fanconi Anemia Research Fund","ror":"https://ror.org/04w07g537"},{"id":"https://openalex.org/F4320319919","display_name":"Saskatchewan Health Research Foundation","ror":"https://ror.org/00trnds81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008895037.pdf","grobid_xml":"https://content.openalex.org/works/W2008895037.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W1640183712","https://openalex.org/W1799442365","https://openalex.org/W1927581912","https://openalex.org/W1964033294","https://openalex.org/W1964143371","https://openalex.org/W1965784004","https://openalex.org/W1968989012","https://openalex.org/W1970449119","https://openalex.org/W1972171756","https://openalex.org/W1974058909","https://openalex.org/W1976933659","https://openalex.org/W1978559422","https://openalex.org/W1978833946","https://openalex.org/W1985420075","https://openalex.org/W1986550902","https://openalex.org/W1996984611","https://openalex.org/W2000516676","https://openalex.org/W2000531777","https://openalex.org/W2000988465","https://openalex.org/W2002006123","https://openalex.org/W2005676761","https://openalex.org/W2006575165","https://openalex.org/W2013941137","https://openalex.org/W2013982103","https://openalex.org/W2014561472","https://openalex.org/W2018644522","https://openalex.org/W2019068162","https://openalex.org/W2021061167","https://openalex.org/W2021860235","https://openalex.org/W2022133986","https://openalex.org/W2023353541","https://openalex.org/W2025373592","https://openalex.org/W2025669923","https://openalex.org/W2026957636","https://openalex.org/W2027513549","https://openalex.org/W2027573386","https://openalex.org/W2027945401","https://openalex.org/W2029874057","https://openalex.org/W2031035364","https://openalex.org/W2031212222","https://openalex.org/W2032512258","https://openalex.org/W2032640722","https://openalex.org/W2033332310","https://openalex.org/W2034410412","https://openalex.org/W2037978116","https://openalex.org/W2040795152","https://openalex.org/W2040881136","https://openalex.org/W2046298637","https://openalex.org/W2054241325","https://openalex.org/W2057831681","https://openalex.org/W2058703060","https://openalex.org/W2061494556","https://openalex.org/W2064853448","https://openalex.org/W2067133520","https://openalex.org/W2075765538","https://openalex.org/W2076430028","https://openalex.org/W2079113974","https://openalex.org/W2079324836","https://openalex.org/W2080380418","https://openalex.org/W2081297341","https://openalex.org/W2084113219","https://openalex.org/W2084158547","https://openalex.org/W2084751512","https://openalex.org/W2085313669","https://openalex.org/W2086639667","https://openalex.org/W2087452637","https://openalex.org/W2090377588","https://openalex.org/W2090953848","https://openalex.org/W2094888311","https://openalex.org/W2095217602","https://openalex.org/W2095599512","https://openalex.org/W2096692378","https://openalex.org/W2098245314","https://openalex.org/W2100493498","https://openalex.org/W2105190461","https://openalex.org/W2105439835","https://openalex.org/W2107090468","https://openalex.org/W2109014179","https://openalex.org/W2109173575","https://openalex.org/W2109630092","https://openalex.org/W2114382972","https://openalex.org/W2117249902","https://openalex.org/W2117602431","https://openalex.org/W2118726620","https://openalex.org/W2122003098","https://openalex.org/W2122536992","https://openalex.org/W2122571070","https://openalex.org/W2123126391","https://openalex.org/W2125038006","https://openalex.org/W2125768070","https://openalex.org/W2126282065","https://openalex.org/W2127392515","https://openalex.org/W2131966344","https://openalex.org/W2132768874","https://openalex.org/W2134327202","https://openalex.org/W2135015314","https://openalex.org/W2135020156","https://openalex.org/W2136058787","https://openalex.org/W2136347342","https://openalex.org/W2138222569","https://openalex.org/W2138707085","https://openalex.org/W2138845922","https://openalex.org/W2142596193","https://openalex.org/W2144430926","https://openalex.org/W2146549847","https://openalex.org/W2149047619","https://openalex.org/W2150490516","https://openalex.org/W2150788604","https://openalex.org/W2151010172","https://openalex.org/W2154595537","https://openalex.org/W2155703790","https://openalex.org/W2156324690","https://openalex.org/W2157113406","https://openalex.org/W2159324439","https://openalex.org/W2161232591","https://openalex.org/W2165613558","https://openalex.org/W2166288313","https://openalex.org/W2166483233","https://openalex.org/W2167844213","https://openalex.org/W2167956098","https://openalex.org/W2170219057","https://openalex.org/W4249363328"],"related_works":["https://openalex.org/W2185265782","https://openalex.org/W1979985126","https://openalex.org/W3035803480","https://openalex.org/W2107090468","https://openalex.org/W2044085946","https://openalex.org/W4405108130","https://openalex.org/W6910962489","https://openalex.org/W2090953848","https://openalex.org/W2777956957","https://openalex.org/W2094888311"],"abstract_inverted_index":{"Conserved":[0],"Iron-Sulfur":[1],"(Fe-S)":[2],"clusters":[3],"are":[4,13,25,36],"found":[5],"in":[6,15,65,133],"a":[7,47,91],"growing":[8],"family":[9],"of":[10,60,74,80,94,117,149],"metalloproteins":[11],"that":[12,31,143],"implicated":[14],"prokaryotic":[16],"and":[17,21,28,35,57,78,135],"eukaryotic":[18],"DNA":[19,26,43,66],"replication":[20,51],"repair.":[22],"Among":[23],"these":[24],"helicase":[27,118,134],"helicase-nuclease":[29,136],"enzymes":[30,137],"preserve":[32,146],"chromosomal":[33],"stability":[34],"genetically":[37],"linked":[38],"to":[39,50,54,138,145],"diseases":[40],"characterized":[41],"by":[42],"repair":[44],"defects":[45],"and/or":[46],"poor":[48],"response":[49],"stress.":[52],"Insight":[53],"the":[55,61,75,99,108,127,147,150],"structural":[56,72],"functional":[58],"importance":[59],"conserved":[62,109,128],"Fe-S":[63,81,100,129],"domain":[64,112],"helicases":[67],"has":[68],"been":[69],"gleaned":[70],"from":[71],"studies":[73],"purified":[76],"proteins":[77],"characterization":[79],"cluster":[82,101,130],"site-directed":[83],"mutants.":[84],"In":[85],"this":[86],"review,":[87],"we":[88],"will":[89,121],"provide":[90],"current":[92],"perspective":[93],"what":[95],"is":[96],"known":[97],"about":[98],"helicases,":[102],"with":[103],"an":[104],"emphasis":[105],"on":[106],"how":[107,126],"redox":[110],"active":[111],"may":[113],"facilitate":[114],"mechanistic":[115],"aspects":[116],"function.":[119],"We":[120],"discuss":[122],"testable":[123],"models":[124],"for":[125],"might":[131],"operate":[132],"conduct":[139],"their":[140],"specialized":[141],"functions":[142],"help":[144],"integrity":[148],"genome.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}