{"id":"https://openalex.org/W2008829904","doi":"https://doi.org/10.1161/circulationaha.114.001382","title":"Pharmacogenomics","display_name":"Pharmacogenomics","publication_year":2015,"publication_date":"2015-02-02","ids":{"openalex":"https://openalex.org/W2008829904","doi":"https://doi.org/10.1161/circulationaha.114.001382","mag":"2008829904","pmid":"https://pubmed.ncbi.nlm.nih.gov/25645611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318121"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.114.001382","doi":"https://doi.org/10.1161/circulationaha.114.001382","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.114.001382","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.001382","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.001382","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087026299","display_name":"Sara L. Van Driest","orcid":"https://orcid.org/0000-0003-2580-1405","observed_orcids":["https://orcid.org/0000-0003-2580-1405"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara L. Van Driest","raw_affiliation_strings":["From Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104387160","display_name":"Steven A. Webber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Webber","raw_affiliation_strings":["From Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":0.2111,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.14698795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"131","issue":"5","first_page":"503","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":1.0},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.8769999742507935},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9045161604881287},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.8630490899085999},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5411016941070557},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5327993035316467},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4658212661743164},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44132474064826965},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4300328195095062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37343549728393555},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.18882039189338684},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13132426142692566},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12914186716079712},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11797097325325012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11572501063346863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0995645523071289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010372","descriptor_name":"Pediatrics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010372","descriptor_name":"Pediatrics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/circulationaha.114.001382","doi":"https://doi.org/10.1161/circulationaha.114.001382","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.114.001382","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.001382","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:25645611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25645611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4318121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.114.001382","doi":"https://doi.org/10.1161/circulationaha.114.001382","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.114.001382","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.001382","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1966362897","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR)","funder_award_id":"KL2TR000446","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2488172526","display_name":null,"funder_award_id":"L40 HD077698","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8724268796","display_name":"Optimizing Outcome After Pediatric Heart Transplantation","funder_award_id":"P50HL074732","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008829904.pdf","grobid_xml":"https://content.openalex.org/works/W2008829904.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W7133913","https://openalex.org/W139566873","https://openalex.org/W1489673102","https://openalex.org/W1528677968","https://openalex.org/W1536139957","https://openalex.org/W1860816854","https://openalex.org/W1878142115","https://openalex.org/W1965214548","https://openalex.org/W1968917799","https://openalex.org/W1975163547","https://openalex.org/W1977560862","https://openalex.org/W1987997716","https://openalex.org/W1991007121","https://openalex.org/W1991471509","https://openalex.org/W1993617813","https://openalex.org/W1999393212","https://openalex.org/W1999690450","https://openalex.org/W2000059017","https://openalex.org/W2003289724","https://openalex.org/W2017464725","https://openalex.org/W2023471159","https://openalex.org/W2029373240","https://openalex.org/W2030965885","https://openalex.org/W2037554320","https://openalex.org/W2039288367","https://openalex.org/W2043241855","https://openalex.org/W2045595216","https://openalex.org/W2046654961","https://openalex.org/W2049662448","https://openalex.org/W2049677093","https://openalex.org/W2050697524","https://openalex.org/W2055664024","https://openalex.org/W2056897801","https://openalex.org/W2058710761","https://openalex.org/W2067610735","https://openalex.org/W2070136137","https://openalex.org/W2073404514","https://openalex.org/W2074024827","https://openalex.org/W2084950732","https://openalex.org/W2086242616","https://openalex.org/W2091212941","https://openalex.org/W2093252196","https://openalex.org/W2099016928","https://openalex.org/W2105311148","https://openalex.org/W2108330841","https://openalex.org/W2108688343","https://openalex.org/W2110926406","https://openalex.org/W2113931509","https://openalex.org/W2115033722","https://openalex.org/W2123034125","https://openalex.org/W2129395887","https://openalex.org/W2158864490","https://openalex.org/W2160334360","https://openalex.org/W2161331298","https://openalex.org/W2164286407","https://openalex.org/W2168127783","https://openalex.org/W2223124369","https://openalex.org/W2315521739","https://openalex.org/W2394853796","https://openalex.org/W2402900764"],"related_works":["https://openalex.org/W4214924050","https://openalex.org/W4240649850","https://openalex.org/W846124577","https://openalex.org/W2096474501","https://openalex.org/W2921806460","https://openalex.org/W4385282744","https://openalex.org/W2024913341","https://openalex.org/W3022143520","https://openalex.org/W2153548261","https://openalex.org/W3107374875"],"abstract_inverted_index":{"knowledge":[0],"of":[1,10,21],"the":[2,6],"pathways":[3,23],"that":[4],"regulate":[5],"expression":[7],"and":[8,13],"function":[9],"enzymes,":[11],"transporters,":[12],"drug":[14],"targets,":[15],"variation":[16],"in":[17],"these":[18],"important":[19],"components":[20],"pharmacological":[22],"are":[24],"being":[25],"discovered.":[26]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
