{"id":"https://openalex.org/W2008805405","doi":"https://doi.org/10.1007/bf00684951","title":"High-performance liquid chromatography assay of bleomycin in human plasma and rat hepatocytes in culture","display_name":"High-performance liquid chromatography assay of bleomycin in human plasma and rat hepatocytes in culture","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2008805405","doi":"https://doi.org/10.1007/bf00684951","mag":"2008805405","pmid":"https://pubmed.ncbi.nlm.nih.gov/1710176"},"language":"en","primary_location":{"id":"doi:10.1007/bf00684951","doi":"https://doi.org/10.1007/bf00684951","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00684951","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007109220","display_name":"Rachid Mahdadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rachid Mahdadi","raw_affiliation_strings":["Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, France","Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, France","institution_ids":["https://openalex.org/I2279609970"]},{"raw_affiliation_string":"Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030943","display_name":"Abdelraouf Kenani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Abdelraouf Kenani","raw_affiliation_strings":["Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009384040","display_name":"Nicole Pommery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicole Pommery","raw_affiliation_strings":["Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012145650","display_name":"Jean Pommery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Pommery","raw_affiliation_strings":["Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110008188","display_name":"Jean Pierre Henichart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Pierre H\ufffdnichart","raw_affiliation_strings":["Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016499678","display_name":"Michel Lhermitte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Lhermitte","raw_affiliation_strings":["Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France","Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxicologie, Facult\u00e9 de Pharmacie de Lille II, 3 rue du Professeur Laguesse, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I2279609970"]},{"raw_affiliation_string":"Unit\u00e9 INSERM, no. 16, Place de Verdun, F-59045, Lille Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.17578733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"28","issue":"1","first_page":"22","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hepatocyte-culture","display_name":"hepatocyte culture","score":0.6159999966621399},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fluorescence-detection","display_name":"fluorescence detection","score":0.7670000195503235},{"id":"https://openalex.org/keywords/antitumor-antibiotics","display_name":"antitumor antibiotics","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7892879247665405},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7537340521812439},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6390502452850342},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6245172023773193},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5461968779563904},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.5372547507286072},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5326988697052002},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.4422617256641388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2838618755340576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24232539534568787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20178404450416565},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10277870297431946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00684951","doi":"https://doi.org/10.1007/bf00684951","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00684951","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:1710176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1710176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer chemotherapy and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W178924873","https://openalex.org/W1024369525","https://openalex.org/W1521817136","https://openalex.org/W1573669683","https://openalex.org/W1582647566","https://openalex.org/W1594845867","https://openalex.org/W1876711428","https://openalex.org/W1963719018","https://openalex.org/W1979400436","https://openalex.org/W1992139853","https://openalex.org/W1992340374","https://openalex.org/W2000195535","https://openalex.org/W2008145309","https://openalex.org/W2017395290","https://openalex.org/W2025004761","https://openalex.org/W2026855584","https://openalex.org/W2027367329","https://openalex.org/W2040889452","https://openalex.org/W2045799443","https://openalex.org/W2063560408","https://openalex.org/W2064898127","https://openalex.org/W2069280483","https://openalex.org/W2069471304","https://openalex.org/W2069529200","https://openalex.org/W2072482644","https://openalex.org/W2073532174","https://openalex.org/W2075481892","https://openalex.org/W2085367317","https://openalex.org/W2087307665","https://openalex.org/W2110012106","https://openalex.org/W2112830398","https://openalex.org/W2158927142","https://openalex.org/W2302386825","https://openalex.org/W2327668702","https://openalex.org/W2462746754","https://openalex.org/W2467716477","https://openalex.org/W4290268543"],"related_works":["https://openalex.org/W53855675","https://openalex.org/W7099461010","https://openalex.org/W2616503102","https://openalex.org/W2060898022","https://openalex.org/W2889373440","https://openalex.org/W2008145309","https://openalex.org/W2069529200","https://openalex.org/W2008474935","https://openalex.org/W1989228649","https://openalex.org/W1663995803"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}