{"id":"https://openalex.org/W2008794819","doi":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","title":"Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells","display_name":"Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2008794819","doi":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","mag":"2008794819","pmid":"https://pubmed.ncbi.nlm.nih.gov/9603453"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","doi":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199805%2928%3A05%3C1492%3A%3AAID-IMMU1492%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199805%2928%3A05%3C1492%3A%3AAID-IMMU1492%3E3.0.CO%3B2-X","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033363853","display_name":"Sara M Mariani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara M. Mariani","raw_affiliation_strings":["Division of Immunogenetics, German Cancer Research Center, Heidelberg","Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunogenetics, German Cancer Research Center, Heidelberg","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068388891","display_name":"Peter H. Krammer","orcid":"https://orcid.org/0000-0002-4584-1589","observed_orcids":["https://orcid.org/0000-0002-4584-1589"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter H. Krammer","raw_affiliation_strings":["Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17937529"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":3.5849,"has_fulltext":true,"cited_by_count":169,"citation_normalized_percentile":{"value":0.94033208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"5","first_page":"1492","last_page":"1498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8370000123977661},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tnf-family","display_name":"TNF family","score":0.6269999742507935},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd3-t-cells","display_name":"CD3+ T cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cd4-and-cd8-t-cells","display_name":"CD4 and CD8 T cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/anti-cd3-stimulation","display_name":"anti-CD3 stimulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/immune-cell-regulation","display_name":"immune cell regulation","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.7129601240158081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6565802097320557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.561467707157135},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5379633903503418},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5120337605476379},{"id":"https://openalex.org/C120642132","wikidata":"https://www.wikidata.org/wiki/Q14907110","display_name":"ZAP70","level":5,"score":0.5021958351135254},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49756696820259094},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.48885172605514526},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46177729964256287},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4285638630390167},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3859078884124756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2033967673778534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14398890733718872},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1320619285106659},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.08280941843986511}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019463","descriptor_name":"Mice, Inbred MRL lpr","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","doi":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199805%2928%3A05%3C1492%3A%3AAID-IMMU1492%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9603453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9603453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","doi":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1492::aid-immu1492>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199805%2928%3A05%3C1492%3A%3AAID-IMMU1492%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008794819.pdf","grobid_xml":"https://content.openalex.org/works/W2008794819.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1517945724","https://openalex.org/W1977318718","https://openalex.org/W1978857213","https://openalex.org/W1980919524","https://openalex.org/W1984709119","https://openalex.org/W1984719435","https://openalex.org/W1995638825","https://openalex.org/W1997296950","https://openalex.org/W2004645606","https://openalex.org/W2004720912","https://openalex.org/W2016417780","https://openalex.org/W2017578232","https://openalex.org/W2018837825","https://openalex.org/W2041466047","https://openalex.org/W2052691929","https://openalex.org/W2056217426","https://openalex.org/W2076656122","https://openalex.org/W2077793109","https://openalex.org/W2080375720","https://openalex.org/W2087562882","https://openalex.org/W2089476060","https://openalex.org/W2091420555","https://openalex.org/W2092196409","https://openalex.org/W2092508425","https://openalex.org/W2105186639","https://openalex.org/W2113505777","https://openalex.org/W2116958667","https://openalex.org/W2124598613","https://openalex.org/W2125076585","https://openalex.org/W2127993518","https://openalex.org/W2130988210","https://openalex.org/W4313379464"],"related_works":["https://openalex.org/W2018837825","https://openalex.org/W2010913093","https://openalex.org/W2101591799","https://openalex.org/W1508110130","https://openalex.org/W2943665180","https://openalex.org/W2366245656","https://openalex.org/W1759314672","https://openalex.org/W1988854695","https://openalex.org/W2285835120","https://openalex.org/W1994811039"],"abstract_inverted_index":{"Like":[0],"other":[1],"members":[2],"of":[3,31,37,46,125,166,181],"the":[4,29,44,103,112,163,178],"TNF":[5],"family,":[6],"TRAIL/Apo-2":[7],"ligand":[8],"induces":[9],"apoptosis":[10],"in":[11,15,49,82,130,177],"sensitive":[12],"target":[13],"cells":[14,36,59,63,79,90,133,169],"a":[16],"caspase-dependent":[17],"fashion.":[18,85],"We":[19],"recently":[20],"found":[21],"that":[22,96,155],"TRAIL":[23,47,81,93,127,142,157],"may":[24,171],"be":[25],"constitutively":[26],"expressed":[27,80],"on":[28,162],"surface":[30,67,92,126,165],"mouse":[32],"and":[33,39,60,94,111,128,148,158,170,183],"human":[34],"tumor":[35],"T":[38,58,182],"B":[40,62,184],"origin.":[41],"To":[42],"define":[43],"pattern":[45],"expression":[48],"normal":[50],"immune":[51,168],"cells,":[52],"freshly":[53,87],"isolated":[54,88],"splenocytes,":[55],"Concanavalin":[56],"A/IL-2-activated":[57],"lipopolysaccharide-activated":[61],"were":[64,97],"analyzed":[65],"by":[66],"staining":[68],"with":[69,102,134],"or":[70,116,136],"without":[71],"secondary":[72],"stimulation.":[73],"Activated,":[74],"but":[75],"not":[76],"resting,":[77],"CD3+":[78],"an":[83,117],"activation-dependent":[84],"Conversely,":[86],"B220+":[89],"displayed":[91,161],"CD95L":[95,129,159],"retained":[98],"following":[99],"activation.":[100],"Restimulation":[101],"protein":[104,145],"kinase":[105],"C":[106],"activator":[107],"phorbol":[108],"12-myristate":[109],"13-acetate":[110],"calcium":[113],"ionophore":[114],"ionomycin":[115],"agonistic":[118],"anti-CD3":[119],"monoclonal":[120],"antibody":[121],"induced":[122],"significant":[123],"up-regulation":[124,143],"CD3+,":[131],"TCRalphabeta":[132],"CD4+":[135],"CD8+":[137],"phenotype.":[138],"Similarly":[139],"to":[140],"CD95L,":[141],"was":[144],"synthesis":[146],"dependent":[147],"cyclosporin":[149],"A":[150],"sensitive.":[151],"These":[152],"results":[153],"indicate":[154],"both":[156],"are":[160],"cell":[164],"activated":[167],"thus":[172],"represent":[173],"complementary":[174],"effector":[175],"pathways":[176],"regulatory":[179],"functions":[180],"cells.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
