{"id":"https://openalex.org/W2008758335","doi":"https://doi.org/10.1002/ijc.11175","title":"Distinct methylation profiles of glioma subtypes","display_name":"Distinct methylation profiles of glioma subtypes","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W2008758335","doi":"https://doi.org/10.1002/ijc.11175","mag":"2008758335","pmid":"https://pubmed.ncbi.nlm.nih.gov/12794756"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.11175","doi":"https://doi.org/10.1002/ijc.11175","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.11175","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014119953","display_name":"Karen Uhlmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Uhlmann","raw_affiliation_strings":["Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Klaus Rohde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Rohde","raw_affiliation_strings":["Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108481360","display_name":"Constanze Zeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Constanze Zeller","raw_affiliation_strings":["Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077292335","display_name":"Janusz Szyma\u015b","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janusz Szymas","raw_affiliation_strings":["Katedra Patomorfologii Kliniczney, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katedra Patomorfologii Kliniczney, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111640340","display_name":"Siegfried Vogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109045","display_name":"Sankt Gertrauden Krankenhaus","ror":"https://ror.org/01p0ze617","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109045"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siegfried Vogel","raw_affiliation_strings":["Neurochirurgie, Sankt Gertrauden Krankenhaus, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochirurgie, Sankt Gertrauden Krankenhaus, Berlin, Germany","institution_ids":["https://openalex.org/I4210109045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048808832","display_name":"Karola Marczinek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karola Marczinek","raw_affiliation_strings":["Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070349795","display_name":"Gundula Thiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gundula Thiel","raw_affiliation_strings":["Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078248666","display_name":"Peter N\u00fcrnberg","orcid":"https://orcid.org/0000-0002-7228-428X","observed_orcids":["https://orcid.org/0000-0002-7228-428X"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Peter N\u00fcrnberg","raw_affiliation_strings":["FAX: +49-30-9406-3147","Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FAX: +49-30-9406-3147","institution_ids":[]},{"raw_affiliation_string":"Gene Mapping Center, Max-Delbru\u0308ck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Institut fu\u0308r Medizinische Genetik, Universita\u0308tsklinikum Charite\u0301, Humboldt-Universita\u0308t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Gene Mapping Center, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Institut f\u00fcr Medizinische Genetik, Universit\u00e4tsklinikum Charit\u00e9, Humboldt-Universit\u00e4t, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641","observed_orcids":["https://orcid.org/0000-0001-9117-3641"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Laird","raw_affiliation_strings":["Department of Surgery and Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078248666"],"corresponding_institution_ids":["https://openalex.org/I205582932","https://openalex.org/I39343248","https://openalex.org/I7877124"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":3.2433,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.92143121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"1","first_page":"52","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma-subtypes","display_name":"glioma subtypes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cpg-island-hypermethylation","display_name":"CpG island hypermethylation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cpg-island-hypomethylation","display_name":"CpG island hypomethylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pilocytic-astrocytoma","display_name":"pilocytic astrocytoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oligodendroglioma","display_name":"oligodendroglioma","score":0.949999988079071},{"id":"https://openalex.org/keywords/oligoastrocytoma","display_name":"oligoastrocytoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-specific-methylation","display_name":"tumor-specific methylation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.8289999961853027},{"id":"https://openalex.org/keywords/methylight","display_name":"MethyLight","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.531000018119812},{"id":"https://openalex.org/keywords/epigenotype","display_name":"epigenotype","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7136878967285156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6824464201927185},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6710360050201416},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.593657374382019},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.5400366187095642},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5206845998764038},{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.4939303994178772},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4804767668247223},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4729810953140259},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.444497674703598},{"id":"https://openalex.org/C2777722931","wikidata":"https://www.wikidata.org/wiki/Q2095252","display_name":"Pilocytic astrocytoma","level":4,"score":0.4253350496292114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23197323083877563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2253355085849762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18740367889404297},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17154067754745483},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08889633417129517}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009837","descriptor_name":"Oligodendroglioma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009837","descriptor_name":"Oligodendroglioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.11175","doi":"https://doi.org/10.1002/ijc.11175","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.11175","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:12794756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12794756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1550758436","display_name":null,"funder_award_id":"N01-HD-8-3284","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2900069587","display_name":"BRAIN AND TISSUE BANK FOR DEVELOPMENTAL DISORDERS","funder_award_id":"n01hd083284-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8359087141","display_name":null,"funder_award_id":"NOI-HD-8-3284","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W86409836","https://openalex.org/W1480917519","https://openalex.org/W1516326873","https://openalex.org/W1528634627","https://openalex.org/W1531180106","https://openalex.org/W1552528612","https://openalex.org/W1556996865","https://openalex.org/W1658127082","https://openalex.org/W1963541583","https://openalex.org/W1975223632","https://openalex.org/W2020206240","https://openalex.org/W2025504334","https://openalex.org/W2046274628","https://openalex.org/W2046509449","https://openalex.org/W2054536503","https://openalex.org/W2061493538","https://openalex.org/W2064838548","https://openalex.org/W2069294039","https://openalex.org/W2074767937","https://openalex.org/W2081561760","https://openalex.org/W2091414779","https://openalex.org/W2106680700","https://openalex.org/W2106816824","https://openalex.org/W2110511887","https://openalex.org/W2117661585","https://openalex.org/W2128146359","https://openalex.org/W2128221451","https://openalex.org/W2147977885","https://openalex.org/W2166075028"],"related_works":["https://openalex.org/W2182911771","https://openalex.org/W1486290736","https://openalex.org/W3111736511","https://openalex.org/W4298043192","https://openalex.org/W2149814701","https://openalex.org/W2337866396","https://openalex.org/W2963181412","https://openalex.org/W7203607240","https://openalex.org/W2318417541","https://openalex.org/W6902278708"],"abstract_inverted_index":{"Gliomas":[0],"are":[1],"tumors":[2],"of":[3,12,38,96,116,152,176,204],"the":[4,27,58,123,202],"central":[5],"nervous":[6],"system":[7],"with":[8,21,201],"a":[9,22,74,131],"wide":[10],"spectrum":[11],"different":[13,97,118],"tumor":[14,80,156],"types.":[15,81],"They":[16],"range":[17],"from":[18,62],"pilocytic":[19,92,171,205],"astrocytoma,":[20],"generally":[23],"good":[24],"prognosis,":[25],"to":[26,34,70,77,129,185],"extremely":[28],"aggressive":[29],"malignant":[30],"glioblastoma.":[31],"In":[32,82],"addition":[33],"these":[35,153],"2":[36],"types":[37],"contrasting":[39],"neoplasms,":[40],"several":[41],"other":[42],"subtypes":[43,195],"can":[44],"be":[45,71],"distinguished,":[46],"each":[47],"characterized":[48],"by":[49],"specific":[50,157,167,210],"phenotypic,":[51],"as":[52,54,60,73,163,165,212,214],"well":[53,164,213],"genotypic":[55],"features.":[56],"Recently,":[57],"epigenotype,":[59],"evident":[61],"differentially":[63],"methylated":[64],"DNA":[65],"loci,":[66],"has":[67],"been":[68],"proposed":[69],"useful":[72],"further":[75],"criterion":[76],"distinguish":[78],"between":[79],"our":[83],"study,":[84],"we":[85],"screened":[86],"139":[87],"tissue":[88,162],"samples,":[89],"including":[90],"33":[91,108],"astrocytomas,":[93,206],"46":[94],"astrocytomas":[95,172],"grades,":[98],"7":[99],"oligoastrocytomas,":[100],"10":[101,103],"oligodendrogliomas,":[102],"glioblastoma":[104],"multiforme":[105],"samples":[106],"and":[107,149],"control":[109,186],"tissues,":[110,187],"for":[111],"methylation":[112,158,168,198],"at":[113,188],"CpG":[114,177],"islands":[115],"15":[117],"gene":[119,132],"loci.":[120],"We":[121,160],"used":[122],"semiquantitative":[124],"high":[125],"throughput":[126],"method":[127],"MethyLight":[128],"analyze":[130],"panel":[133],"comprising":[134],"ARF,":[135],"CDKN2B,":[136],"RB1,":[137],"APC,":[138],"CDH1,":[139],"ESR1,":[140],"GSTP1,":[141],"TGFBR2,":[142],"THBS1,":[143],"TIMP3,":[144],"PTGS2,":[145],"CTNNB1,":[146],"CALCA,":[147],"MYOD1":[148],"HIC1.":[150],"Seven":[151],"loci":[154],"showed":[155,173],"changes.":[159],"found":[161],"grade":[166],"profiles.":[169],"Interestingly,":[170],"no":[174],"evidence":[175],"island":[178],"hypermethylation,":[179],"but":[180],"were":[181],"significantly":[182],"hypomethylated,":[183],"relative":[184],"MYOD1.":[189],"Our":[190],"results":[191],"show":[192,207],"that":[193],"glioma":[194],"have":[196],"characteristic":[197],"profiles":[199],"and,":[200],"exception":[203],"both":[208],"locus":[209],"hyper-":[211],"hypomethylation.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}