{"id":"https://openalex.org/W2008757745","doi":"https://doi.org/10.1523/jneurosci.5491-11.2012","title":"Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1","display_name":"Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1","publication_year":2012,"publication_date":"2012-07-25","ids":{"openalex":"https://openalex.org/W2008757745","doi":"https://doi.org/10.1523/jneurosci.5491-11.2012","mag":"2008757745","pmid":"https://pubmed.ncbi.nlm.nih.gov/22836275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3490187"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.5491-11.2012","doi":"https://doi.org/10.1523/jneurosci.5491-11.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5491-11.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/30/10423.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/32/30/10423.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kendall R. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendall R. Walker","raw_affiliation_strings":["Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051714797","display_name":"Eugene L. Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene L. Kang","raw_affiliation_strings":["Alzheimer's Disease Research Laboratory , Depart- ment of Neuroscience , Tufts University School of Medicine , 136 Harrison Avenue , St 328A , Boston , MA 02111 ","Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Laboratory , Depart- ment of Neuroscience , Tufts University School of Medicine , 136 Harrison Avenue , St 328A , Boston , MA 02111 ","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111,","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083117986","display_name":"Michael J. Whalen","orcid":"https://orcid.org/0000-0001-8208-5981","observed_orcids":["https://orcid.org/0000-0001-8208-5981"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Whalen","raw_affiliation_strings":["Neuroscience Center and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101397547","display_name":"Yong Shen","orcid":"https://orcid.org/0000-0002-5048-8134","observed_orcids":["https://orcid.org/0000-0002-5048-8134"]},"institutions":[{"id":"https://openalex.org/I59283426","display_name":"Roskamp Institute","ror":"https://ror.org/02b10nq15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59283426"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Shen","raw_affiliation_strings":["Center for Advanced Therapeutic Strategies for Brain Disorders (CATSBD), Roskamp Institute, Sarasota, Florida 34243"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Therapeutic Strategies for Brain Disorders (CATSBD), Roskamp Institute, Sarasota, Florida 34243","institution_ids":["https://openalex.org/I59283426"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025046197","display_name":"Giuseppina Tesco","orcid":"https://orcid.org/0000-0002-3336-7488","observed_orcids":["https://orcid.org/0000-0002-3336-7488"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giuseppina Tesco","raw_affiliation_strings":["Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111,","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025046197"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":null,"apc_paid":null,"fwci":2.5898,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.89830808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"32","issue":"30","first_page":"10423","last_page":"10437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gga1","display_name":"GGA1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gga3","display_name":"GGA3","score":1.0},{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8450000286102295},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8119999766349792},{"id":"https://openalex.org/keywords/head-trauma","display_name":"head trauma","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.441506028175354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4007789194583893},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34141695499420166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33367452025413513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1556149125099182},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.5491-11.2012","doi":"https://doi.org/10.1523/jneurosci.5491-11.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5491-11.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/30/10423.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2552666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3490187","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3490187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3490187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:22836275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22836275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.5491-11.2012","doi":"https://doi.org/10.1523/jneurosci.5491-11.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5491-11.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/30/10423.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3610932421","display_name":"BACE1 regulation and TNFR Type II receptor in Alzheimers disease","funder_award_id":"R01AG025888","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4821014688","display_name":"Role of BACE in the pathogenesis of Alzheimer's disease after head trauma","funder_award_id":"R01AG033016","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6734258643","display_name":"Role of BACE stabilization in Alzheimer's disease","funder_award_id":"R01AG025952","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7831551873","display_name":"Study on Thalidomide as BACE1 inhibitor in Alzhiemer's disease","funder_award_id":"R01AG034155","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008757745.pdf","grobid_xml":"https://content.openalex.org/works/W2008757745.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1480468820","https://openalex.org/W1553957684","https://openalex.org/W1596984737","https://openalex.org/W1672576559","https://openalex.org/W1857364306","https://openalex.org/W1965918817","https://openalex.org/W1968794453","https://openalex.org/W1970483892","https://openalex.org/W1971077103","https://openalex.org/W1979837593","https://openalex.org/W1983730442","https://openalex.org/W1989282675","https://openalex.org/W1989349429","https://openalex.org/W1990393999","https://openalex.org/W1993168711","https://openalex.org/W1996194647","https://openalex.org/W1998149522","https://openalex.org/W1998383478","https://openalex.org/W2000536660","https://openalex.org/W2000688919","https://openalex.org/W2001402586","https://openalex.org/W2006454362","https://openalex.org/W2008087702","https://openalex.org/W2015190044","https://openalex.org/W2022647670","https://openalex.org/W2023819682","https://openalex.org/W2029214965","https://openalex.org/W2030975919","https://openalex.org/W2032080482","https://openalex.org/W2033067082","https://openalex.org/W2035738127","https://openalex.org/W2036162274","https://openalex.org/W2038003980","https://openalex.org/W2039782226","https://openalex.org/W2042600422","https://openalex.org/W2047198245","https://openalex.org/W2047418563","https://openalex.org/W2050669612","https://openalex.org/W2052172724","https://openalex.org/W2052240111","https://openalex.org/W2058880763","https://openalex.org/W2059938441","https://openalex.org/W2063646837","https://openalex.org/W2067991812","https://openalex.org/W2072504660","https://openalex.org/W2075604126","https://openalex.org/W2076868543","https://openalex.org/W2081458774","https://openalex.org/W2082700144","https://openalex.org/W2086070682","https://openalex.org/W2086396932","https://openalex.org/W2088835723","https://openalex.org/W2090751165","https://openalex.org/W2093426751","https://openalex.org/W2094185290","https://openalex.org/W2095367777","https://openalex.org/W2100026237","https://openalex.org/W2105830710","https://openalex.org/W2106903768","https://openalex.org/W2110242050","https://openalex.org/W2118539817","https://openalex.org/W2120522615","https://openalex.org/W2122046606","https://openalex.org/W2126442818","https://openalex.org/W2130313087","https://openalex.org/W2130473558","https://openalex.org/W2131565097","https://openalex.org/W2133019124","https://openalex.org/W2137832426","https://openalex.org/W2138879406","https://openalex.org/W2139599612","https://openalex.org/W2140975116","https://openalex.org/W2141792156","https://openalex.org/W2144539581","https://openalex.org/W2147486806","https://openalex.org/W2147889480","https://openalex.org/W2164735970","https://openalex.org/W4229972528"],"related_works":["https://openalex.org/W2101838754","https://openalex.org/W2001402586","https://openalex.org/W1603503372","https://openalex.org/W2047198245","https://openalex.org/W2786152420","https://openalex.org/W2029431901","https://openalex.org/W1991517647","https://openalex.org/W3100220025","https://openalex.org/W4312087146","https://openalex.org/W6990949904"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,93],"injury":[2,61],"(TBI)":[3],"is":[4,19,27,50,122],"one":[5],"of":[6,25,32,68,75,80,94,160,175,189,214,224,236,250],"the":[7,35,45,57,73,78,92,110,200,227,233,237,247],"most":[8],"robust":[9,222],"environmental":[10],"risk":[11],"factors":[12],"for":[13],"Alzheimer's":[14],"disease":[15],"(AD).":[16],"Compelling":[17],"evidence":[18],"accumulating":[20],"that":[21,44,86,100,117,148,158,182,212],"a":[22,65,119,123,173,219],"single":[23],"event":[24],"TBI":[26],"associated":[28],"with":[29],"increased":[30,90,171],"levels":[31,54,88,159,169,193,196,245],"A\u03b2.":[33],"However,":[34,232],"underlying":[36],"molecular":[37],"mechanisms":[38],"remain":[39],"unknown.":[40],"We":[41,70,97],"report":[42],"here":[43],"BACE1":[46,53,81,87,104,137,168,190,225,240],"interacting":[47],"protein,":[48],"GGA3,":[49],"depleted":[51,127,166],"while":[52,167,194],"increase":[55],"in":[56,64,77,82,91,106,109,143,145,172,186,199,226,246],"acute":[58,111,228],"phase":[59,112,202,229,249],"after":[60,113,131,205,230],"(48":[62],"h)":[63],"mouse":[66],"model":[67],"TBI.":[69,132],"further":[71],"demonstrated":[72],"role":[74],"GGA3":[76,120,141,151,164,183,217,244],"regulation":[79],"vivo":[83],"by":[84,140],"showing":[85],"are":[89,165,170,197],"GGA3-null":[95,107],"mice.":[96],"next":[98],"found":[99,157],"head":[101],"trauma":[102],"potentiates":[103,136],"elevation":[105,138,188,223],"mice":[108],"TBI,":[114],"and":[115,150,163,191,216,221],"discovered":[116],"GGA1,":[118],"homolog,":[121],"novel":[124],"caspase-3":[125],"substrate":[126],"at":[128],"48":[129],"h":[130],"Moreover,":[133],"GGA1":[134,149,162,195,215],"silencing":[135],"induced":[139],"deletion":[142],"neurons":[144],"vitro,":[146],"indicating":[147],"synergistically":[152],"regulate":[153],"BACE1.":[154],"Accordingly,":[155],"we":[156,180],"both":[161],"series":[174],"postmortem":[176],"AD":[177],"brains.":[178],"Finally,":[179],"show":[181],"haploinsufficiency":[184],"results":[185],"sustained":[187],"A\u03b2":[192],"restored":[198],"subacute":[201,248],"(7":[203],"d)":[204],"injury.":[206,231,251],"In":[207],"conclusion,":[208],"our":[209],"data":[210],"indicate":[211],"depletion":[213],"engender":[218],"rapid":[220],"efficient":[234],"disposal":[235],"acutely":[238],"accumulated":[239],"solely":[241],"depends":[242],"on":[243]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}