{"id":"https://openalex.org/W2008707603","doi":"https://doi.org/10.1038/oby.2005.95","title":"Protein Tyrosine Phosphatase 1B Variant Associated with Fat Distribution and Insulin Metabolism","display_name":"Protein Tyrosine Phosphatase 1B Variant Associated with Fat Distribution and Insulin Metabolism","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2008707603","doi":"https://doi.org/10.1038/oby.2005.95","mag":"2008707603","pmid":"https://pubmed.ncbi.nlm.nih.gov/15919835"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2005.95","doi":"https://doi.org/10.1038/oby.2005.95","is_oa":false,"landing_page_url":"https://doi.org/10.1038/oby.2005.95","pdf_url":null,"source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039191725","display_name":"Olavi H. Ukkola","orcid":"https://orcid.org/0000-0001-7414-2608","observed_orcids":["https://orcid.org/0000-0001-7414-2608"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Olavi Ukkola","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA","Department of Internal Medicine and Biocenter, University of Oulu, Oulu, Finland","Pennington Biomedical Research Center, Baton Rouge, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"raw_affiliation_string":"Department of Internal Medicine and Biocenter, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Pennington Biomedical Research Center, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108075607","display_name":"Tuomo Rankinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuomo Rankinen","raw_affiliation_strings":["#N#        Pennington Biomedical Research Center, Baton Rouge, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#        Pennington Biomedical Research Center, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047887151","display_name":"Timo Antero Lakka","orcid":"https://orcid.org/0000-0002-9199-2871","observed_orcids":["https://orcid.org/0000-0002-9199-2871"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Timo Lakka","raw_affiliation_strings":["Kuopio Research Institute of Exercise Medicine, and Department of Physiology, University of Kuopio, Kuopio, Finland","Pennington Biomedical Research Center, Baton Rouge, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuopio Research Institute of Exercise Medicine, and Department of Physiology, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Pennington Biomedical Research Center, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108417853","display_name":"Arthur S. Leon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S. Leon","raw_affiliation_strings":["School of Kinesiology, University of Minnesota, Minneapolis, Minnesota;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Kinesiology, University of Minnesota, Minneapolis, Minnesota;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103148993","display_name":"James S. Skinner","orcid":"https://orcid.org/0000-0002-9259-4007","observed_orcids":["https://orcid.org/0000-0002-9259-4007"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Skinner","raw_affiliation_strings":["Department of Kinesiology, Indiana University, Bloomington, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, Indiana University, Bloomington, Indiana","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110421257","display_name":"Jack H. Wilmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack H. Wilmore","raw_affiliation_strings":["Department of Kinesiology and Health Education , University of Texas at Austin, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education , University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112148462","display_name":"D. C. Rao","orcid":"https://orcid.org/0009-0006-8538-2141","observed_orcids":["https://orcid.org/0009-0006-8538-2141","https://orcid.org/0000-0001-7629-9879"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.C. Rao","raw_affiliation_strings":["Division of Biostatistics, Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007142","display_name":"Y. Antero Kes\u00e4niemi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Y.A. Kes\u00e4niemi","raw_affiliation_strings":["Department of Internal Medicine and Biocenter, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Biocenter, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060568681","display_name":"Claude Bouchard","orcid":"https://orcid.org/0000-0002-0048-491X","observed_orcids":["https://orcid.org/0000-0002-0048-491X"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claude Bouchard","raw_affiliation_strings":["#N#        Pennington Biomedical Research Center, Baton Rouge, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#        Pennington Biomedical Research Center, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3806,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77911848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"5","first_page":"829","last_page":"834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.36550000309944153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9779999852180481},{"id":"https://openalex.org/keywords/body-fat-distribution","display_name":"body fat distribution","score":0.8489999771118164},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7360000014305115},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6549999713897705},{"id":"https://openalex.org/keywords/disposition-index","display_name":"disposition index","score":0.6970000267028809},{"id":"https://openalex.org/keywords/leptin-receptor-gene","display_name":"leptin receptor gene","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/type-2-diabetes-risk","display_name":"type 2 diabetes risk","score":0.8960000276565552},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.828000009059906},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/skinfold-thickness","display_name":"skinfold thickness","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8113127946853638},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8006601929664612},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.62815260887146},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5886159539222717},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5063904523849487},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4809543490409851},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.45881491899490356},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4312686324119568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3555721044540405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34065163135528564},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3241015076637268},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.23284223675727844}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012885","descriptor_name":"Skinfold Thickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018149","descriptor_name":"Glucose Intolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/oby.2005.95","doi":"https://doi.org/10.1038/oby.2005.95","is_oa":false,"landing_page_url":"https://doi.org/10.1038/oby.2005.95","pdf_url":null,"source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},{"id":"pmid:15919835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15919835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1213007958","display_name":"HERITAGE - GENETICS, RESPONSE TO EXERCISE, RISK FACTORS","funder_award_id":"R01HL047327","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1965402563","display_name":null,"funder_award_id":"HL 47321","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2315488758","display_name":null,"funder_award_id":"HL 45670","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2674690430","display_name":null,"funder_award_id":"HL47323","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3556897874","display_name":"HERITAGE FAMILY STUDY - DCC","funder_award_id":"R01HL047317","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G712748038","display_name":null,"funder_award_id":"HL 47327","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7551033996","display_name":"HERITAGE:GENETICS RESPONSE TO EXERCISE RISK FACTORS-III","funder_award_id":"R01HL047323","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G832931031","display_name":null,"funder_award_id":"HL47317","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8709543126","display_name":"HERITAGE FAMILY STUDY, PHASE 4","funder_award_id":"R01HL045670","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8898038003","display_name":"HERITAGE: Genetics, Response to Exercise, Risk Factors","funder_award_id":"R01HL047321","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1496740734","https://openalex.org/W1988456343","https://openalex.org/W2012016304","https://openalex.org/W2014129040","https://openalex.org/W2016954161","https://openalex.org/W2029342409","https://openalex.org/W2040780260","https://openalex.org/W2046519484","https://openalex.org/W2058418427","https://openalex.org/W2082449959","https://openalex.org/W2082998114","https://openalex.org/W2085679956","https://openalex.org/W2088075259","https://openalex.org/W2105702707","https://openalex.org/W2116500202","https://openalex.org/W2123229219","https://openalex.org/W2135020700","https://openalex.org/W2143578581","https://openalex.org/W2167822623","https://openalex.org/W2333611329","https://openalex.org/W4241472476","https://openalex.org/W4292691146"],"related_works":["https://openalex.org/W2156621965","https://openalex.org/W2125797784","https://openalex.org/W2148086158","https://openalex.org/W1503207064","https://openalex.org/W2597846922","https://openalex.org/W7098633247","https://openalex.org/W2150392518","https://openalex.org/W1974547747","https://openalex.org/W7099485308","https://openalex.org/W2033420302"],"abstract_inverted_index":{"Protein":[0],"tyrosine":[1],"phosphatase":[2],"1B":[3],"(PTPN1)":[4],"affects":[5],"the":[6,19,27,52,59,69,72,97,105,186,194],"regulation":[7],"of":[8,86,166,169,197],"insulin":[9,46,127,146,198],"signaling":[10],"and":[11,35,51,84,92,111,121,130,151,188],"energy":[12],"metabolism.":[13],"We":[14],"studied":[15],"whether":[16],"polymorphisms":[17],"in":[18,26,32],"PTPN1":[20,73,120,139,160,187,201],"gene":[21,124],"impact":[22],"body":[23,78],"fat":[24,79,95],"distribution":[25],"HERITAGE":[28],"Family":[29],"Study":[30],"cohort":[31],"502":[33],"white":[34],"276":[36],"black":[37],"subjects.":[38],"Insulin":[39],"sensitivity":[40,128],"index,":[41,44],"glucose":[42,49,63,152,208],"disappearance":[43,153],"acute":[45],"response":[47],"to":[48,135,193],"(AIR(glucose)),":[50],"disposition":[53,112],"index":[54,113,129,154],"(DI)":[55],"were":[56],"obtained":[57],"from":[58,133],"frequently":[60],"sampled":[61],"intravenous":[62],"tolerance":[64],"test.":[65],"White":[66],"subjects":[67,103],"with":[68,143,206],"G82G":[70],"at":[71,176],"IVS6+G82A":[74],"polymorphism":[75],"had":[76,104],"higher":[77,164,177],"levels":[80,165],"(p":[81,89,99,108,114,132,148,155],"=":[82,90,100,109,115,149,156],"0.031)":[83],"sum":[85],"eight":[87],"skinfolds":[88],"0.003)":[91],"highest":[93],"subcutaneous":[94],"on":[96],"limbs":[98],"0.002).":[101],"G82A":[102],"lowest":[106],"AIR(glucose)":[107,131],"0.005)":[110],"0.040).":[116],"Interaction":[117],"effects":[118],"between":[119,185],"leptin":[122,189],"receptor":[123,190],"variants":[125],"influenced":[126],"0.006":[134],"0.010).":[136],"The":[137,200],"variant":[138,203],"Pro387Leu":[140,202],"was":[141,204],"associated":[142,205],"lower":[144,207],"fasting":[145],"level":[147],"0.035)":[150],"0.038).":[157],"In":[158],"summary,":[159],"IVS6+G82G":[161],"homozygotes":[162],"showed":[163],"all":[167],"measures":[168],"adiposity.":[170],"G82":[171],"allele":[172],"heterozygotes":[173],"are":[174],"potentially":[175],"risk":[178],"for":[179],"type":[180],"2":[181],"diabetes.":[182],"Gene-gene":[183],"interactions":[184],"genes":[191],"contributed":[192],"phenotypic":[195],"variability":[196],"sensitivity.":[199],"tolerance.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
